Deletion of Cd248 in Postn + myofibroblast fails to attenuate pressure-overload induced cardiac remodeling and fibrosis in mice
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Cardiac fibrosis driven by activated myofibroblasts is a central feature of pressure-overload heart disease. CD248 (Endosialin/TEM1) has been implicated as a pro-fibrotic marker in ischemic cardiac injury, but its role in pressure overload remains unclear. Her... ...
