Innate immune signal transduction pathways to fungal infection: Components and regulation [0.03%]
先天免疫信号转导通路在真菌感染中的作用：组成和调节
Tian Chen,Chengjiang Gao
Tian Chen
Candida species are significant causes of mucosal and systemic infections in immune compromised populations, including HIV-infected individuals and cancer patients. Drug resistance and toxicity have limited the use of anti-fungal drugs. A g...
Lincheng Zhang,Haotian Bai,Jing Zhou et al.
Lincheng Zhang et al.
Peripheral tumor-specific CD8+ T cells often fail to infiltrate into tumor parenchyma due to the immunosuppression of tumor microenvironment (TME). Meanwhile, a significant portion of tumor-specific CD8+ T cells infiltrated into TME are fun...
YanYan Zhu,Fengping Liu,Fenglei Jian et al.
YanYan Zhu et al.
Autophagy, a lysosome-dependent degradation process, plays a crucial role in maintaining cell homeostasis. It serves as a vital mechanism for adapting to stress and ensuring intracellular quality control. Autophagy deficiencies or defects a...
PD-1-mediated inhibition of T cell activation: Mechanisms and strategies for cancer combination immunotherapy [0.03%]
PD-1介导的T细胞激活抑制：机制及癌症联合免疫治疗策略
Rui Liu,Hui-Fang Li,Shu Li
Rui Liu
The programmed cell death 1 (PD-1) immune checkpoint of co-inhibitory signaling plays crucial roles in controlling the magnitude and duration of T cell activation to limit tissue damage and maintain self-tolerance. Cancer cells hijack the c...
Function and mechanism of bispecific antibodies targeting SARS-CoV-2 [0.03%]
靶向SARS-CoV-2的双特异性抗体的功能和机制
Zhaohui Li,Zengyuan Zhang,Steven T Rosen et al.
Zhaohui Li et al.
As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune e...
Lin He,Yiping Cao,Luyang Sun
Lin He
Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modification...
STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy [0.03%]
STING指导STX17-SNAP29-VAMP8复合物组装以控制自噬过程
Xiaoyu Song,Yufeng Xi,Ming Dai et al.
Xiaoyu Song et al.
The stimulator of interferon genes (STING) plays a pivotal role in orchestrating innate immunity, and dysregulated activity of STING has been implicated in the pathogenesis of autoimmune diseases. Recent findings suggest that bacterial infe...
Erratum regarding missing declaration of interests in previously published articles [0.03%]
关于先前已发表文章中缺失的利益冲突声明的勘误
[This corrects the article DOI: 10.1016/j.cellin.2022.100033.][This corrects the article DOI: 10.1016/j.cellin.2022.100031.][This corrects the article DOI: 10.1016/j.cellin.2022.100057.][This corrects the article DOI: 10.1016/j.cellin.2022....
Published Erratum
Cell insight. 2024 Jan 30;3(1):100148. DOI:10.1016/j.cellin.2024.100148 2024
Meiyue Dong,Jazmin M Galvan Achi,Ruikun Du et al.
Meiyue Dong et al.
The global outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) threatened human health and public safety. The development of anti-SARS-CoV-2 therapies have been essential to curb the spread of SARS-CoV-2. Particular...
Elafibranor emerged as a potential chemotherapeutic drug for non-muscle invasive bladder cancer [0.03%]
Elafibranor作为非肌肉侵袭性膀胱癌的潜在化疗药物崭露头角
Wang Wang,Danni Shan,Guanyi Wang et al.
Wang Wang et al.
Intravesical infusion of chemotherapeutics is highly recommended by several clinical guidelines for treating nonmuscle invasive bladder cancer (NMIBC). However, cytotoxic chemotherapeutics can cause a series of side effects, which greatly l...