Identification of Foxm1 as a critical regulator for metabolic dysfunction-associated steatotic liver disease by epigenomic and transcriptional profiling [0.03%]
通过表观遗传和转录谱分析鉴定Foxm1是与代谢紊乱相关脂肪变性肝病的关键调节因子
Chuanfei Zeng,Mingliang Wei,Huan Li et al.
Chuanfei Zeng et al.
Epigenetic regulation has emerged as a key mechanism in metabolic dysfunction-associated steatotic liver disease (MASLD). However, the systematic epigenomic profiling for MASLD progression is still lacking. To investigate the epigenetic mec...
FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos [0.03%]
精细的EM-seq：一种快速等温扩增方法，可对斑马鱼早期胚胎进行全面甲基组谱分析
Chenyang Ding,Qifeng Zhang,Jing Wang et al.
Chenyang Ding et al.
DNA methylation plays a crucial role in development and disease. Bisulfite-free methods such as enzymatic methyl sequencing (EM-seq) offer gentle approaches for whole-genome analysis, but they typically depend on PCR-based library amplifica...
Ketone body metabolism activates the immune response against Staphylococcus aureus infection by fueling the tricarboxylic acid cycle and affecting histone β-hydroxybutyrylation [0.03%]
酮体代谢通过为三羧酸循环供能并影响组蛋白β-羟丁酰化来激活对金黄色葡萄球菌感染的免疫应答
Huanhuan Cai,Xin Yue,Yingbo Chen et al.
Huanhuan Cai et al.
Staphylococcus aureus (S. aureus) is a prominent human pathogen that causes persistent inflammation and is notoriously difficult to treat. Fasting is one of host adaptations to infection, and the induction of ketogenesis and ketolysis is a ...
Viperin weakens IFN-I-induced immune activity by facilitating STAT1 degradation through E3 ligase UBE4A [0.03%]
通过E3泛素连接酶UBE4A促进STAT1降解从而削弱I型干扰素诱导的免疫反应的 viperin
Ying Miao,Yukang Yuan,Liping Qian et al.
Ying Miao et al.
Viperin is considered as an antiviral protein known to directly target a variety of viruses. However, whether and how Viperin affects virus infection by targeting intracellular immune signaling remain unexplored. Here, we reveal that Viperi...
Capicua mediates interleukin-2 withdrawal-induced death of activated CD8+ T cells [0.03%]
Capicua介导的IL-2撤除引起的活化CD8⁺T细胞死亡
Jun-Ge Shi,Ye Xu,Wen-Hao Hang et al.
Jun-Ge Shi et al.
During the course of an immune response, antigen-reactive T cells undergo clonal expansion and are subsequently eliminated by cytokine withdrawal-induced cell death (CWID), an intrinsic apoptotic program essential for immune homeostasis. Ho...
Podophyllotoxin sensitizes triple-negative breast cancer cells to CD47-targeted immunotherapy [0.03%]
鬼臼毒素可通过抑制糖酵解增强CD47靶向免疫疗法抵抗三阴性乳腺癌干细胞的功能与机制研究
Jessica Dang,Nuozi Song,Jingkai Zhou et al.
Jessica Dang et al.
Triple-negative breast cancer (TNBC) remains a highly aggressive malignancy with limited therapeutic options. Immunotherapeutic strategies are emerging as promising avenues to improve clinical outcomes in TNBC. Among these, CD47, a critical...
Zizhen Ming,Bing Su,Qiming Liang
Zizhen Ming
The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that regulates multiple key cellular processes. It assembles into two major multi-protein complexes, called mTOR complex (mTORC)1 and mTORC2, ...
Molecular basis of fox ACE2 recognition by receptor binding domains of SARS-CoV-2 and PCoV-GD [0.03%]
反式冠状病毒受体结合域识别狐狸ACE2的分子机制
Chenghai Wang,Xiaoyan Nan,Chaozhu Pei et al.
Chenghai Wang et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive RNA detected in red fox swab samples provide evidence of a natural SARS-CoV-2 infection in this species. Many studies have also demonstrated that the red fox angioten...
Yuxiao Zheng,Dezhen Tu,Chen Dong et al.
Yuxiao Zheng et al.
Lipid metabolism disorders have been identified in various chronic diseases that are also closely linked with immune cells and inflammatory microenvironment. As pivotal innate immune cells, macrophages exhibit remarkable heterogeneity. Lipi...
TNF inhibits SARS-CoV-2 induced cell-cell fusion through activating the SDC4-RhoA signaling to promote actin bundles formation [0.03%]
肿瘤坏死因子通过激活SDC4-RhoA信号促进肌动蛋白束形成，从而抑制SARS-CoV-2诱导的细胞融合
Dong Duan,Xu Zheng,Yanqiu Zhou et al.
Dong Duan et al.
SARS-CoV-2 infection-induced syncytia formation accelerates cell-to-cell transmission of the virus and enhances viral evasion by neutralizing antibodies. Host innate immune response plays a key role in controlling viral infection. Our prese...