Febrile-range temperature selectively limits sustained pDC-Derived IFN-α via attenuation of STAT1-Dependent feedback signaling [0.03%]
发热范围的温度通过减弱STAT1介导的反馈信号选择性限制持续的pDC来源IFN-α生成
Yangyang Xu,Hao Yang,Lin Yang et al.
Yangyang Xu et al.
Plasmacytoid dendritic cells (pDCs) are specialized sentinels of antiviral immunity and the dominant early source of interferon-α (IFN-α) during viral infection. While pDC-derived IFN-α restricts viral replication and provides a critical...
Phage tail protein methylation enabling the virus to bind to the surface of bacterial cells is vital for progeny infectivity [0.03%]
噬菌体尾蛋白甲基化对子代病毒感染活性至关重要
Sijia Fan,Junlong Li,Yuyun Wei et al.
Sijia Fan et al.
The importance of methylation-based protein modifications in viral infection remains largely unknown. Here, we show that phage tail protein methylation depending on a host-encoded enzyme, MepM, is vital for maintaining the viral infectivity...
GPAT4 regulates antitumor immune response through activating the mtDNA-cGAS axis in cancer cells [0.03%]
GPAT4通过在癌细胞中激活mtDNA-cGAS轴调节抗肿瘤免疫反应
Zi-Lun Ruan,Wei Liang,Yu-Tong Gong et al.
Zi-Lun Ruan et al.
Activating tumor-intrinsic innate immune pathways can promote tumor antigen presentation and immune cell recruitment, thereby improving the immunosuppressive microenvironment and overcoming resistance to immune checkpoint blockade (ICB). Ho...
Beyond adaptive immunity: Functional diversity of the type III-A CRISPR-Cas system in Mycobacterium tuberculosis [0.03%]
超越适应性免疫：结核分枝杆菌III-A型CRISPR-Cas系统功能多样性研究
Wenjing Yu,Xindi Huang,Yangbo Hu et al.
Wenjing Yu et al.
CRISPR-Cas systems are best known as prokaryotic adaptive immune pathways that defend against invading genetic elements. Mycobacterium tuberculosis (Mtb) harbors a type III-A CRISPR-Cas system that is structurally conserved yet exhibits lit...
Type III Druantia two-component antiphage defense depends on the DruH-DruE interaction for inhibiting viral DNA circularization and replication [0.03%]
III型Druantia双组分抗噬菌体防御依赖于DruH-DruE相互作用以抑制病毒DNA环化及复制
Yakun Li,Zheng-Guo He
Yakun Li
Bacteria have evolved multiple immune systems to resist phage invasion, however, only a small part of the defensive mechanisms have been clearly uncovered. In this study, we report a type III Druantia two-component defense system, DruH-DruE...
Regulation of cellular functions and diseases by the MARCH E3 ubiquitin ligases [0.03%]
MARCH泛素连接酶对细胞功能和疾病的作用及调控
Qi Zhang,Yu-Ting Qiao,Shu Li
Qi Zhang
The membrane-associated RING-CH (MARCH) family is a type of membrane-localized E3 ubiquitin ligase, which catalyze substrate ubiquitination via their characteristic RING-CH domains. MARCH proteins target their substrates for polyubiquitinat...
Xiaoqiu Shu,Xinyuan Yu,Pinglong Xu et al.
Xiaoqiu Shu et al.
Marked by protein aggregation, impaired proteostasis, organelle stress, and chronic neuroinflammation, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) form a clinically, genetically, and pathologically overlapping dise...
PAF1c depletion confers chemoresistance to topoisomerase inhibitors [0.03%]
PAF1复合体的损耗可使拓扑异构酶抑制剂产生耐药性
Dingwei Li,Chunbo Zhu,Tailun Wang et al.
Dingwei Li et al.
The human RNA polymerase II-associated factor 1 complex (PAF1c) functions in transcriptional elongation and mRNA maturation. PAF1c is composed of several subunits: PAF1, CDC73, LEO1, CTR9, RTF1, and SKIC8. Besides its role in transcription,...
Xiaorui Liu,Congqing Jiang,Youjun Li
Xiaorui Liu
Endogenous metabolites are a class of bioactive metabolic molecules synthesized endogenously within the organism that mediate core physiological processes, spanning bioactive small-molecule compounds, carbohydrates, nucleotides, and gut mic...
Non-canonical clonal expansion of autoreactive CD8+ T cells following influenza infection [0.03%]
流感感染后自身反应性CD8+t细胞非规范克隆扩增
Shiyue Hou,Hai Qi
Shiyue Hou
T cell receptors (TCRs) are inherently polyreactive. A vast repertoire of polyreactive TCRs not only ensure a response to essentially all possible microbial antigen but also underlies the host susceptibility to autoimmunity, which may be tr...