The methyltransferase SETD3 regulates mRNA alternative splicing through interacting with hnRNPK [0.03%]
甲基转移酶SETD3通过与hnRNPK互作调控mRNA剪接
Yue-Yu Kong,Wen-Jie Shu,Shuang Wang et al.
Yue-Yu Kong et al.
The methyltransferase SETD3 is an enzyme essential for catalyzing histidine-73 methylation on β-Actin, thereby promoting its polymerization and regulating muscle contraction. Although increasing evidence suggests that SETD3 is involved in ...
Aoqun Song,Yunting Wang,Cuifang Liu et al.
Aoqun Song et al.
During the development of eukaryote, faithful inheritance of chromatin states is central to the maintenance of cell fate. DNA replication poses a significant challenge for chromatin state inheritance because every nucleosome in the genome i...
Jianying Liu,Yixin Quan,Hua Tong et al.
Jianying Liu et al.
The increasing global prevalence of mosquito-borne viruses has emerged as a significant threat to human health and life. Identifying receptors for these viruses is crucial for improving our knowledge of viral pathogenesis and developing eff...
Lianxin Hu,Qing Zhang
Lianxin Hu
TANK-binding kinase 1 (TBK1) is a serine/threonine kinase with well-established roles as a central player in innate immune signaling. Dysregulation of TBK1 activity has been implicated in a variety of pathophysiologic conditions, including ...
Finding new roles of classic biomolecular condensates in the nucleus: Lessons from fission yeast [0.03%]
经典生物分子凝聚体在细胞核中的新作用：源于芽殖酵母的启示
Tomoyasu Sugiyama
Tomoyasu Sugiyama
Decades have passed since the initial discovery of membrane-less nuclear compartments, commonly called nuclear bodies or nuclear condensates. These compartments have drawn attention to their unique characteristics and functions, especially ...
Qiankun Wang,Liang Shan
Qiankun Wang
Human immunodeficiency virus (HIV) continues to be a significant global health challenge despite decades of research and advances in treatment. Substantial gaps in our understanding of the mechanisms of HIV pathogenesis and the host immune ...
Transcriptomic analysis of mouse TRAMP cell lines and tumors provide insights into shared pathways and therapeutic targets [0.03%]
小鼠TRAMP细胞系和肿瘤的转录组分析揭示了共享途径和治疗靶点的新见解
Marxa L Figueiredo,Sagar Utturkar,Shreya Kumar et al.
Marxa L Figueiredo et al.
The present study focused on comparing the gene expression profiles of different mouse models of prostate cancer, focusing on the TRAMP transgenic model and its derived cell lines and extending the comparisons to relevant genetically engine...
ATR/Chk1 interacting lncRNA modulates DNA damage response to induce breast cancer chemoresistance [0.03%]
调控DNA损伤反应以诱导乳腺癌化疗耐药的ATR/Chk1相互作用lncRNA
Rong Luo,Jiannan Wu,Xueman Chen et al.
Rong Luo et al.
The ATR-Chk1 pathway is essential in cellular responses to DNA damage and replication stress, whereas the role of long noncoding RNAs (lncRNAs) in regulating this pathway remains largely unknown. In this study, we identify an ATR and Chk1 i...
Deacetylation of GLUD1 maintains the survival of lung adenocarcinoma cells under glucose starvation by inhibiting autophagic cell death [0.03%]
GLUD1脱乙酰基作用通过抑制自噬性细胞死亡维持葡萄糖剥夺条件下肺腺癌细胞的存活
Qifan Hu,Longhua Sun,Zhujun Cheng et al.
Qifan Hu et al.
Enhanced glutamine catabolism is one of the main metabolic features of cancer, providing energy and intermediate metabolites for cancer progression. However, the functions of glutamine catabolism in cancer under nutrient deprivation need to...
Xue-Mei Yi,Ya-Li Lei,Mi Li et al.
Xue-Mei Yi et al.
Monkeypox virus (MPXV) is a DNA virus belonging to the Orthopoxvirus genus within the Poxviridae family which can cause a zoonotic infection. The unexpected non-endemic outbreak of mpox in 2022 is considered as a new global threat. It is im...