Hongyuan Qu,Yi Zhen,Mohan Xu et al.
Hongyuan Qu et al.
Cortactin-dependent control of Par1b-regulated epithelial cell polarity in Helicobacter infection [0.03%]
Helicobacter感染中Pyk2依赖的Par1b调节上皮细胞极性的控制作用
Irshad Sharafutdinov,Aileen Harrer,Mathias Müsken et al.
Irshad Sharafutdinov et al.
Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen Helicobacter pylori hijacks Par1b via the bacterial oncopr...
Baige Li,Ting Xie,Scott Nawy et al.
Baige Li et al.
The ciliary body, located at the junction of the choroid and iris, is crucial in the development of the embryonic eye. Notch2 signalling, Wnt signalling, transforming growth factor β (TGF-β) signalling, and Pax6 signalling are critical fo...
LUC7L3 is a downstream factor of SRSF1 and prevents genomic instability [0.03%]
LUC7L3是SRSF1的下游因子，可防止基因组不稳定
Xiaqing Zhang,Jing Guo,Xin Shi et al.
Xiaqing Zhang et al.
The RNA-binding protein LUC7L3 is the human homolog of yeast U1 small nuclear RNA (snRNA)-related splicing factor Luc7p. While the primary function of LUC7L3 as an RNA-binding protein is believed to be involved in RNA metabolism, particular...
Yang Yang,Yi-Zhen Chen,Tian Xia
Yang Yang
Tuberculosis (TB) remains a prevalent global infectious disease caused by genetically closely related tubercle bacilli in Mycobacterium tuberculosis complex (MTBC). For a century, the Bacillus Calmette-Guérin (BCG) vaccine has been the pri...
ACE2-using merbecoviruses: Further evidence of convergent evolution of ACE2 recognition by NeoCoV and other MERS-CoV related viruses [0.03%]
使用ACE2的默贝科病毒：NeoCoV和其他与MERS相关的病毒对ACE2识别趋同进化的进一步证据
Qing Xiong,Chengbao Ma,Chen Liu et al.
Qing Xiong et al.
Angiotensin-converting enzyme 2 (ACE2) was recognized as an entry receptor shared by coronaviruses from Sarbecovirus and Setracovirus subgenera, including three human coronaviruses: SARS-CoV, SARS-CoV-2, and NL63. We recently disclosed that...
Innate immune signal transduction pathways to fungal infection: Components and regulation [0.03%]
先天免疫信号转导通路在真菌感染中的作用：组成和调节
Tian Chen,Chengjiang Gao
Tian Chen
Candida species are significant causes of mucosal and systemic infections in immune compromised populations, including HIV-infected individuals and cancer patients. Drug resistance and toxicity have limited the use of anti-fungal drugs. A g...
Lincheng Zhang,Haotian Bai,Jing Zhou et al.
Lincheng Zhang et al.
Peripheral tumor-specific CD8+ T cells often fail to infiltrate into tumor parenchyma due to the immunosuppression of tumor microenvironment (TME). Meanwhile, a significant portion of tumor-specific CD8+ T cells infiltrated into TME are fun...
YanYan Zhu,Fengping Liu,Fenglei Jian et al.
YanYan Zhu et al.
Autophagy, a lysosome-dependent degradation process, plays a crucial role in maintaining cell homeostasis. It serves as a vital mechanism for adapting to stress and ensuring intracellular quality control. Autophagy deficiencies or defects a...
PD-1-mediated inhibition of T cell activation: Mechanisms and strategies for cancer combination immunotherapy [0.03%]
PD-1介导的T细胞激活抑制：机制及癌症联合免疫治疗策略
Rui Liu,Hui-Fang Li,Shu Li
Rui Liu
The programmed cell death 1 (PD-1) immune checkpoint of co-inhibitory signaling plays crucial roles in controlling the magnitude and duration of T cell activation to limit tissue damage and maintain self-tolerance. Cancer cells hijack the c...