The NF-κB-SLC7A11 axis regulates ferroptosis sensitivity in inflammatory macrophages [0.03%]
NF-κB-SLC7A11轴调节炎性巨噬细胞的铁死亡敏感性
Mengjie Yang,Xiaowei Chen,Xiran Hu et al.
Mengjie Yang et al.
M1-polarized macrophages exhibit remarkable resistance to ferroptosis, a form of regulated cell death driven by excessive lipid peroxidation. Yet the underlying mechanisms remain to be defined. Through CRISPR-based functional screen of meta...
Yaobin Jing,Jie Ren,Jing Qu et al.
Yaobin Jing et al.
Aging is characterized by a progressive decline in organ and tissue structure and function, significantly increasing the risk of many chronic diseases. Developing interventions to delay aging holds the potential to reduce the burden of age-...
TFAP4 exacerbates pathological cardiac fibrosis by modulating mechanotransduction [0.03%]
TFAP4通过调节机械转导加重病理性心脏纤维化
Jie Liu,Jingjing Feng,Jingxuan Zhao et al.
Jie Liu et al.
Cardiac fibroblast (CF) differentiation into myofibroblasts is a crucial driver of cardiac fibrosis, leading to extensive extracellular matrix (ECM) deposition that increases myocardial stiffness and eventually impairs heart function. Mecha...
Integrated 4D label-free proteome and SUMOylated proteome in glioma uncover novel pathological mechanisms and pave the way for precision therapy [0.03%]
整合的4D无标签蛋白质组和SUMO修饰蛋白质组揭示胶质瘤新病理机制并为精准治疗铺路
Jiazheng Wang,Zhuo Li,Kaijie Mu et al.
Jiazheng Wang et al.
Glioma, the most common primary intracranial tumor, has seen increased scrutiny with the advent of high-throughput detection technologies, yet many aspects of its tumorigenesis and progression remain enigmatic. In this study, we utilized 4D...
IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner [0.03%]
IRF1以正反馈方式放大HSV-1触发的抗病毒先天免疫反应
Ming Gao,Yining Qi,Junjie Zhang
Ming Gao
Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that establishes lifelong infection and causes a wide range of diseases. Antiviral innate immunity is critical for controlling HSV-1 replication; however, how host cells elicit a ...
Rapid and direct discovery of functional tumor specific neoantigens by high resolution mass spectrometry and novel algorithm prediction [0.03%]
基于高分辨率质谱和新型算法预测的快速直接发现功能性肿瘤新抗原
Huajian Tian,Guifei Li,Cookson K C Chiu et al.
Huajian Tian et al.
While immune cell therapies have transformed cancer treatment, achieving comparable success in solid tumors remains a significant challenge compared to hematologic malignancies like non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). Over...
Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways [0.03%]
单细胞测序和糖尿病肾脏空间多组学分段见解：具有区带特异性的治疗代谢途径
Shi Qiu,Zhibo Wang,Sifan Guo et al.
Shi Qiu et al.
Diabetic nephropathy (DN) exhibits profound spatial metabolic heterogeneity across kidney regions, yet how compartmentalized pathways drive disease progression remains poorly defined. A deeper understanding of the organizational spatial env...
Yutong Liu,Pinglong Xu
Yutong Liu
Cyclic GMP-AMP synthase (cGAS) functions as a pivotal intracellular sensor for the innate immune sensing of double-stranded DNA (dsDNA), monitoring those nucleic acids from foreign and endogenous sources. Upon assembling into cellular conde...
The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption [0.03%]
瞬时受体电位通道V4在急性睡眠剥夺引起的记忆损伤中的作用：钙失调和突触可塑性损伤的机制研究
Meimei Guo,Feiyang Zhang,Sha Liu et al.
Meimei Guo et al.
Acute sleep deprivation (ASD) impairs memory formation, but the underlying mechanisms remain unclear. In this study, we employed an ASD model combined with fear conditioning to investigate these mechanisms. mRNA sequencing revealed upregula...
Corrigendum to "STING guides the STX17-SNAP29-VAMP8 complex assembly to control autophagy" [Cell Insight 3 (2024) 100147] [0.03%]
关于“STING引导STX17-SNAP29-VAMP8复合体组装以控制自噬”一文的勘误CELL INSIGHT 3 (2024) 100147]
Xiaoyu Song,Yufeng Xi,Ming Dai et al.
Xiaoyu Song et al.
[This corrects the article DOI: 10.1016/j.cellin.2024.100147.]. © 2025 The Author(s).
Published Erratum
Cell insight. 2025 Apr 11;4(3):100239. DOI:10.1016/j.cellin.2025.100239 2025