Long non-coding RNA and non-coding nucleic acids: Signaling players in the networks of the tumor ecosystem [0.03%]
长链非编码RNA和非编码核酸：肿瘤生态系统网络中的信号分子
Xiaorong Lin,Man-Li Luo,Erwei Song
Xiaorong Lin
Recent findings have revealed that human genome encodes tens of thousands long noncoding RNAs (lncRNAs), which play essential roles in broad spectrum of cellular processes. Emerging evidence has uncovered a new archetype of lncRNAs which fu...
Yuwei Huang,Li Yu
Yuwei Huang
The migrasome is a newly discovered organelle of migrating cells. Migrasomes play diverse physiological roles including mitochondrial quality control, lateral transfer of material between cells, and delivery of signaling molecules to spatia...
Single-cell transcriptomic landscape identifies the expansion of peripheral blood monocytes as an indicator of HIV-1-TB co-infection [0.03%]
单细胞转录组揭示外周血单核细胞扩张为HIV-1结核杆菌共感染的标志
Qinglong Guo,Yu Zhong,Zhifeng Wang et al.
Qinglong Guo et al.
Certain circulating cell subsets are involved in immune dysregulation in human immunodeficiency virus type 1 (HIV-1) and tuberculosis (TB) co-infection; however, the characteristics and role of these subclusters are unknown. Peripheral bloo...
Hong-Bing Shu
Hong-Bing Shu
Yan Yang,Su-Yun Wang,Zhen-Qi Li et al.
Yan Yang et al.
Bone homeostasis is maintained through continuous remodeling by osteoclast-driven bone resorption and osteoblast-mediated bone formation. Osteoclasts are multinucleated giant cells (MNCs) differentiated from myeloid progenitors of the monoc...
Regulation and function of the cGAS-MITA/STING axis in health and disease [0.03%]
cGAS-MITA/STING信号通路的调控及其生理和病理功能研究进展
Zhi-Dong Zhang,Bo Zhong
Zhi-Dong Zhang
The innate immune systems detect pathogens via pattern-recognition receptors including nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS, also known as MB21D1) i...
Dong Guo,Ying Meng,Xiaoming Jiang et al.
Dong Guo et al.
Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal roles in glucose metabolism through canonical functions of hexokinases as well as in immune response, cell stemness, autophagy, and other cellular ac...
Atlas of interactions between SARS-CoV-2 macromolecules and host proteins [0.03%]
SARS-CoV-2大型分子与宿主蛋白相互作用图集
Guangnan Li,Zhidong Tang,Weiliang Fan et al.
Guangnan Li et al.
The proteins and RNAs of viruses extensively interact with host proteins after infection. We collected and reanalyzed all available datasets of protein-protein and RNA-protein interactions related to SARS-CoV-2. We investigated the reproduc...
Intertwined regulation between RNA m6A modification and cancer metabolism [0.03%]
RNA m6A修饰与癌症代谢的相互调控关系研究进展
Jiaxu Liu,Hao Huang,Minghao Zhang et al.
Jiaxu Liu et al.
RNA N6-methyladenosine (m6A) has been identified as the most common, abundant and conserved internal modification in RNA transcripts, especially within eukaryotic messenger RNAs (mRNAs). Accumulating evidence demonstrates that RNA m6A modif...
Structural basis of the TCR-pHLA complex provides insights into the unconventional recognition of CDR3β in TCR cross-reactivity and alloreactivity [0.03%]
TCR-pHLA复合物的结构基础提供了关于TCR交叉反应和同种反应中非传统识别CDR3β的见解
Dan San,Jun Lei,Yang Liu et al.
Dan San et al.
Evidence shows that some class I human leucocyte antigen (HLA) alleles are related to durable HIV controls. The T18A TCR, which has the alloreactivity between HLA-B∗42:01 and HLA-B∗81:01 and the cross-reactivity with different antigen mut...