Small but mighty: ATG9A-positive vesicles are a branch of the intracellular nanovesicle superfamily [0.03%]
小而强大：ATG9A阳性囊泡是胞内纳米囊泡超级家族的一个支系
Mary Fesenko,Stephen J Royle
Mary Fesenko
The molecular and functional characterization of the thousands of uncoated intracellular transport vesicles inside cells is a major challenge. Intracellular nanovesicles (INVs) are a large and molecularly heterogenous family of uncoated tra...
Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy [0.03%]
穿行于神经元“回收箱”——再探亨廷顿蛋白在自噬调控中的作用
Thomas J Krzystek,Shermali Gunawardena
Thomas J Krzystek
Neurons, as post-mitotic and long-lived cells, rely heavily on autophagy to maintain cellular homoeostasis and ensure proper function. Huntingtin (HTT), a protein central to Huntington's disease (HD), has emerged as a putative multifunction...
Active protein quality control in quiescence: involvement of proteasomes, autophagy, and nucleus-vacuole junctions [0.03%]
静止状态下的活性蛋白质质量控制：蛋白酶体、自噬和核 vac 界点的参与
Mihaela Pravica,Dina Franić,Mirta Boban
Mihaela Pravica
Quiescence is a conserved, reversible state of proliferative arrest, characterized by changes in cell physiology and metabolism. Many cells spend a considerable part of their lifetime in quiescence, including adult stem cells or microorgani...
A plasmid module for PCR-based gene modification for the accurate measurement of vacuolar delivery of specific proteins in yeast Saccharomyces cerevisiae [0.03%]
一种质粒模块通过PCR基因改造在酵母中精确测定特定蛋白质向液泡的递送
Jakob Valdbjørn Kanne,Fulvio Reggiori
Jakob Valdbjørn Kanne
Monitoring the delivery of single proteins and protein complexes to the vacuole by autophagy or other processes in yeast Saccharomyces cerevisiae mainly relies on western blot or fluorescence microscopy analyses using endogenous tagging of ...
The TECPR1:ATG5-ATG12 complex conjugates LC3/ATG8 to damaged lysosomes that expose luminal glycans in response to osmotic imbalance [0.03%]
TECPR1:ATG5-ATG12 复合物将LC3/ATG8连接到渗透失衡时暴露腔内聚糖的受损溶酶体上
Yingxue Wang,Matthew Jefferson,Maria Ramos et al.
Yingxue Wang et al.
Hydrolytic enzymes within lysosomes maintain cell and tissue homoeostasis by degrading macromolecules delivered by endocytosis and autophagy. The release of lysosomal enzymes into the cytosol can induce apoptosis and "lysosome-dependent cel...
Functional cooperation between ATG7/autophagy and the PALB2 tumor suppressor in mitochondrial regulation, redox homeostasis, and neuronal health [0.03%]
ATG7/自噬与PALB2肿瘤抑制因子在线粒体调节、氧化还原平衡和神经元健康方面的功能协作
Yanying Huo,Akshada Sawant,Eileen White et al.
Yanying Huo et al.
In a recently published study, we described a genetic interaction and functional cooperation between Atg7, an essential autophagy gene, and Palb2, a breast cancer susceptibility gene, in the maintenance of mitochondrial function, redox home...
Adriana Marcelo,Carlos A Matos,Clévio Nóbrega
Adriana Marcelo
The accumulation of misfolded proteins and fibrillar aggregates inside neurons is a hallmark of several neurodegenerative diseases. While the exact role of these aggregates is still controversial, they are part of a cascade of molecular eve...
Ubiquitin Modification of SARS-CoV-2 Membrane Protein Promotes Virion Assembly and Budding via Autophagy [0.03%]
SARS-CoV-2膜蛋白泛素化修饰促进病毒组装及自噬依赖的出芽释放
Zhen Yuan,Binbin Ding
Zhen Yuan
In our recent study, we reported the molecular mechanisms of SARS-CoV-2 assembly and budding. Envelope protein (E) and membrane protein (M) of SARS-CoV-2 form complexes that ensure the uniform size of viral particles for viral maturation an...
THE BNIP3 TRIAD: MITOCHONDRIA, LYSOSOMES AND INFLAMMATION IN HEALTHY MUSCLE AGING [0.03%]
BNIP3三联体：健康肌肉衰老中的线粒体、溶酶体和炎症反应
Andrea Irazoki,Antonio Zorzano,David Sebastian
Andrea Irazoki
During aging, skeletal muscle undergoes a loss of mass, strength and function, encompassed in the biological process termed sarcopenia. Given demographic aging, it is essential to comprehend the molecular determinants resulting in age-relat...
Intestinal epithelial CGAS dampens inflammation by upregulating autophagy [0.03%]
肠上皮CGAS通过上调自噬抑制炎症反应
Elizabeth A Novak,Heather L Mentrup,Nazih Bizri et al.
Elizabeth A Novak et al.
The pathogenesis of intestinal inflammation involves a complex network of cell signaling pathways. CGAS (cyclic GMP-AMP synthase) is a cytoplasmic DNA sensor that is most known for upregulating interferon-mediated inflammation. In this punc...