Deacetylation of HSC70 by SIRT2 promotes chaperone mediated autophagy
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Chaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation essential for cellular proteostasis. CMA is activated during cellular stress, such as starvation, and involves the chaperone protein HSC70 (HSPA8) recognizing substrates co... ...
