Retinal ganglion cell autophagy: a housekeeper essential for neuronal homeostasis and survival [0.03%]
视网膜节细胞自噬：维持神经元稳态和存活的管家机制
Yogapriya Sundaresan,Gulab S Zode
Yogapriya Sundaresan
Retinal ganglion cells (RGCs) are the sole projection neurons of the retina and the only direct link between retinal circuitry and the brain. Maintaining this lifelong connection requires constitutive autophagy to preserve organelle quality...
FLCN loss is characterized by SQSTM1/p62 accumulation despite functional autophagy flux in Birt-Hogg-Dubé syndrome-associated kidney cancer [0.03%]
FLCN丢失会导致Birt-Hogg-Dubé综合征相关肾癌中SQSTM1/p62聚集尽管自噬流功能正常
Halvor Ullern,Julie Aarmo Johannessen,Feyza Kasikci et al.
Halvor Ullern et al.
Birt-Hogg-Dubé syndrome (BHD) is an autosomal, dominant condition caused by Folliculin (FLCN) mutation and characterized by enhanced risk for kidney tumors. Previous studies have shown constitutive nuclear localization of the transcription...
The role of N-glycans and their processing in ER-to-lysosome-associated degradation of disease-causing mutant Neuroserpin [0.03%]
N-连接聚糖及其加工在内质网向溶酶体传递的神经丝蛋白病理性突变型降解中的作用
Carolin Hoefner,Ilaria Fregno,Maurizio Molinari
Carolin Hoefner
Most proteins synthesized in the endoplasmic reticulum (ER) are covalently modified upon addition of pre-assembled oligosaccharides to side chains of asparagine (N) residues. Processing of N-linked oligosaccharides by ER-resident glucosidas...
Damage control: new functions for the Arp2/3 complex and WHAMM in autophagy and lysosomal homeostasis [0.03%]
损害控制：Arp2/3复合物和WHAMM在自噬和溶酶体稳态中的新功能
Lianna H Wagner,Kenneth G Campellone
Lianna H Wagner
Macroautophagy is an intracellular degradation process that relies on autophagosomes and lysosomes to maintain cellular and organismal homeostasis. Actin cytoskeletal rearrangements driven by the Arp2/3 (actin-related protein 2/3) complex, ...
Autophagy in the liver [0.03%]
肝脏自噬
Elijah Burks,Jenna Copes,Kelly Nguyen et al.
Elijah Burks et al.
The liver plays a dynamic role in maintaining whole-body homeostasis through its control of nutrient metabolism, detoxification, and immune regulation. Autophagy, a conserved lysosomal degradation pathway, is central to these functions, ena...
Seeing is believing: visualizing spatiotemporal lipophagic flux in vivo with the tfLiveDrop reporter mice [0.03%]
见证即信念：用tfLiveDrop报告基因小鼠在体内可视化时空脂噬通量
Siqiao Gong,Chen Yang,Huafeng Liu
Siqiao Gong
Lipophagy, the selective autophagic degradation of lipid droplets (LDs), is central to cellular lipid homeostasis, yet its dynamic regulation in living organisms has remained largely unobservable in real time. To overcome this barrier, we r...
Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons [0.03%]
神经元培养基中葡萄糖浓度影响人诱导多能干细胞来源的神经元中Pink1介导的线粒体自噬
Benjamin O&#x;Callaghan,Daniela Melandri,Darija Soltic et al.
Benjamin O&#x;Callaghan et al.
Parkinson's disease-associated proteins PINK1 and Parkin collaboratively regulate stress-induced mitophagy. While in vitro human neuronal cultures are valuable for studying the roles of PINK1 and Parkin in a disease-relevant context, the im...
AMPK-mediated autophagy induction by bisdemethoxycurcumin attenuates senescence and amyloid pathology in 3xTg-AD mice [0.03%]
姜黄素衍生物诱导的自噬减轻3xTg-AD小鼠细胞衰老和淀粉样蛋白病理损伤的研究
Parul Khajuria,Dilpreet Kour,Kuhu Sharma et al.
Parul Khajuria et al.
Alzheimer disease (AD) pathology is accompanied by increased senescence and reduced levels of autophagy in the brain. We investigated whether pharmacologically inducing autophagy could alter the senescent phenotype and ameliorate AD patholo...
Beyond cargo clearance: p62 coordinates cAMP signalling and autophagy to drive cell fate decisions in Dictyostelium discoideum [0.03%]
超越货物清除：p62在泡状虫中协调cAMP信号传导和自噬以驱动细胞命运决定
Saksham Gautam,Shweta Saran
Saksham Gautam
p62 is a multi-domain selective autophagy receptor and signaling scaffold conserved across eukaryotes. However, its evolutionary roots and functional significance in early-diverging eukaryotes like Dictyostelium have remained unexplored. In...
A review of autophagy in the pancreas: normal physiology and pathophysiology [0.03%]
自噬在胰腺中的作用：生理和病理生理学综述
Miles Piper,Conan Kinsey
Miles Piper
Autophagy is a complex cellular process of cellular degradation that is essential for healthy pancreatic function and, when perturbed, can result in pathological states such as pancreatitis, diabetes, and cancer. Extremes in both activation...