ATG9A-dependent, LC3-independent autophagy curbs the immune system to protect against disease [0.03%]
依赖于ATG9A但独立于LC3的自噬作用抑制免疫系统以防御疾病
Dario Priem,Mathieu Jm Bertrand
Dario Priem
Selective autophagy is generally believed to require the conjugation of microtubule associated protein 1 light chain 3 (LC3) proteins (or other autophagy-related 8 [ATG8] family members) on the inner phagophore leaflet to enable the recruit...
Glycophagy: molecular mechanisms, regulatory signals, and disease associations [0.03%]
糖体吞噬：分子机制、调控信号及其与疾病的关系
Lei Chen,Jinyong Jiang,Meiqing Liu et al.
Lei Chen et al.
Glycophagy is a process of selective degradation of glycogen through the autophagy pathway. It relies on key proteins, such as STBD1 (glycogen-specific autophagy receptor), GABARAPL1 (member of the ATG8 family), and acid α-glucosidase (GAA...
RETREG1/FAM134B-mediated micro-ER-phagy in the retrovirus-SERINC5 arms race [0.03%]
反转录病毒-Serinc5军备竞赛中的RETREG1/FAM134B介导的微内质网自噬作用
Jim Maurice Camilleri,Iqbal Ahmad,Jing Zhang et al.
Jim Maurice Camilleri et al.
Reticulophagy regulator 1 (RETREG1)/Family with sequence similarity 134 member B (FAM134B) is a selective endoplasmic reticulum (ER)-phagy receptor that mediates starvation-induced macro-ER-phagy, but whether it participates in other pathwa...
TFEB-mediated autophagy stimulation as an anabolic strategy for bone: insights from TFEB activation in the osteoblast lineage [0.03%]
TFEB介导的自噬刺激作为骨形成的合成代谢策略：来自TFEB激活的成骨细胞谱系的新见解
Melda Onal
Melda Onal
Autophagy in the osteoblast lineage is essential for bone formation and skeletal homeostasis, yet the mechanisms through which it supports bone formation remain unclear. To investigate these mechanisms and evaluate the anabolic potential of...
Autophagy cargo profiles in skeletal muscle during starvation and exercise [0.03%]
饥饿和运动期间骨骼肌自噬体的组成成分及其动力学变化
Mohd Farhan,Shangze Lyu,Trezze P Nguyen et al.
Mohd Farhan et al.
Autophagy is a cellular process to clear unwanted and dysfunctional cellular cargoes, which are sequestered in autophagosomes before their delivery to lysosomes for degradation. Autophagy cargo selection, mediated by cargo receptors, varies...
Involvement of ACSL3 in the formation of autophagosomes and lipid droplets during starvation conditions [0.03%]
ACSL3在饥饿条件下自噬体和脂滴形成中的作用
Shun Kato,Mitsuo Tagaya
Shun Kato
Acyl-CoA synthetase long-chain (ACSL) catalyzes the conversion of fatty acids into acyl-CoA, which is used for neutral lipid and phospholipid synthesis. Previous studies revealed that yeast Faa1 and mammalian ACSL4 play a crucial role in ph...
Deacetylation of HSC70 by SIRT2 promotes chaperone mediated autophagy [0.03%]
SIRT2去乙酰化HSC70促进分子伴侣介导的自噬
Byunghyun Ahn,Wenzhe Chen,Wenbiao Shi et al.
Byunghyun Ahn et al.
Chaperone-mediated autophagy (CMA) is a selective form of lysosomal protein degradation essential for cellular proteostasis. CMA is activated during cellular stress, such as starvation, and involves the chaperone protein HSC70 (HSPA8) recog...
Illuminating the regulatory link between blue light and autophagy in photomorphogenesis [0.03%]
探究光形态发生中蓝光和自噬之间的调控联系
Lu Jiang,Hong-Quan Yang,Wenxiu Wang
Lu Jiang
Cryptochrome 1 (CRY1) promotes photomorphogenesis primarily by inhibiting Constituttive photomorphogenic 1 (COP1)/Suppressor of PHYA-105 1 (SPA1)-mediated degradation of HY5 via the 26S proteasome degradation pathway. However, it remained u...
CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes [0.03%]
CNX:FAM134B驱动的ERLAD通过内质网与内溶酶体之间VAPA:ORP1L:RAB7接触位点形成增强而进行以ATZ多聚体为底物
Elisa Fasana,Ilaria Fregno,Maurizio Molinari
Elisa Fasana
Membrane contact sites (MCS) between organelles maintain the proximity required for controlled exchange of small molecules and ions yet preventing fusion events that would compromise organelles' identity and integrity. Here, by investigatin...
Aβ and tau clearance through aerobic exercise: unveiling the β2-adrenergic receptor's role in regulating autophagy-lysosomal pathways [0.03%]
有氧运动通过β2肾上腺素受体调节自噬溶酶体途径介导的Aβ和tau清除作用
Liu Yang,Haitao Yu,Gao-Shang Chai
Liu Yang
The systematic dissection of molecular mechanisms through which aerobic exercise (AE) mitigates neurodegenerative pathologies remains a significant challenge. Alzheimer's disease (AD) is characterized by impaired autophagy-lysosomal flux an...