The role of N-glycans and their processing in ER-to-lysosome-associated degradation of disease-causing mutant Neuroserpin
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Most proteins synthesized in the endoplasmic reticulum (ER) are covalently modified upon addition of pre-assembled oligosaccharides to side chains of asparagine (N) residues. Processing of N-linked oligosaccharides by ER-resident glucosidases, mannosidases and... ...
