Interleukin-34 induced Arg1+ macrophages play a key role in breast cancer brain metastasis [0.03%]
白细胞介素34诱导的ARG1+巨噬细胞在乳腺癌脑转移中的关键作用
Xiaoqing Cheng,Khooshbu K Patel,Brandon Zhou et al.
Xiaoqing Cheng et al.
Brain metastases occur in up to 40% of patients with Stage IV breast cancer and the cerebellum is a common site for metastases in HER2 positive breast cancer. We developed a syngeneic, immunocompetent mouse model of breast cancer brain meta...
Enhancing Immunotherapeutic Response in Colorectal Cancer with a Neuropilin-1-Targeting Tumor-Penetrating Peptide [0.03%]
一种靶向神经纤毛蛋白-1的肿瘤穿透肽可增强免疫治疗在结直肠癌中的疗效
Atsushi Fukugaki,Shigeo Hisamori,Dean Thumkeo et al.
Atsushi Fukugaki et al.
Immune checkpoint inhibitors (ICIs) provide durable responses in a subset of colorectal cancers, yet benefit is largely confined to microsatellite instability-high (MSI-H) tumors. We investigated whether the tumor-penetrating peptide iRGD e...
Increased glucose availability sensitizes pancreatic cancer to macrophage-targeting immunotherapies [0.03%]
葡萄糖可用性增加使胰腺癌对巨噬细胞靶向免疫治疗敏感化
Jonathan J Hue,Mehrdad Zarei,Priyashree Sunita et al.
Jonathan J Hue et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) that limits the efficacy of immunotherapies. Many tumor-suppressive immune cells, including inflammatory macrophage subsets, rely ...
Hannah C Beird,Carl Ho,Roberto Cardenas-Zuniga et al.
Hannah C Beird et al.
Many of the >130 WHO-defined sarcoma subtypes are chemoresistant. To identify drug candidates with potential for repurposing in sarcomas with unmet need, we screened structurally diverse small molecules across 20 sarcoma cell lines of vario...
Chronic high-fat diet does not alter overall cancer incidence in Trp53R270H/+ mice [0.03%]
长期高脂饮食不会改变Trp53R270H/+小鼠的整体癌症发病率
Ilaria Panzeri,Zachary B Madaj,Luca Fagnocchi et al.
Ilaria Panzeri et al.
Obesity is a complex chronic disease characterized by excessive adiposity and multiple co-morbidities, including an elevated risk of several cancers. Despite long-standing epidemiological links, the causal relationship between body mass ind...
Assessing feasibility of community-based colorectal cancer screening in Pune, India [0.03%]
评估印度浦那社区结直肠癌筛查的可行性
Smita Joshi,Parimal Lawate,B Kishore Kumar et al.
Smita Joshi et al.
The colorectal cancer (CRC) rates in India are lower than the other Southeast Asian countries but there is a rising trend in incidence as well as mortality. We are reporting the results of a large community-based CRC screening project imple...
Identification of pancreatic ductal adenocarcinoma extracellular matrix signatures from in-depth proteomic profiling that correlate with lymphocyte infiltration [0.03%]
基于蛋白质组深度谱型分析的胰腺导管腺癌细胞外基质标志物的鉴定及其与淋巴细胞浸润的相关性研究
James M Considine,Dharma Pally,Sarah A O&#x;Brien et al.
James M Considine et al.
The extracellular matrix (ECM) is a complex assembly of proteins surrounding cells. It is a critical component of the tumor microenvironment that plays an active role in tumor progression and modulation of tumor response to treatment. Pancr...
Early ctDNA dynamics predict response to mosperafenib in BRAF V600-mutant metastatic colorectal cancer [0.03%]
基线ctDNA动态预测BRAF V600突变转移性结直肠癌对mosrofenib响应的情况
Martha Liliana Serrano-Serrano,Christina Godfried Sie,Oliver Bechter et al.
Martha Liliana Serrano-Serrano et al.
The BRAF V600 mutation confers a poor prognosis in metastatic colorectal cancer (mCRC). Mosperafenib is a novel, paradox-breaking BRAF inhibitor (BRAFi). In this analysis of a phase 1 study (ISRCTN13713551), we evaluated circulating tumor D...
DGAT1 Drives Racially Divergent Fibroblast Activation via ERK1/2-Dependent Tumorigenic Signaling in Prostate Cancer [0.03%]
前列腺癌中DGAT1通过ERK1/2依赖的致癌信号驱动不同人种间成纤维细胞活化
Sathyavathi ChallaSivaKanaka,Mamatha Kakarla,Renee E Vickman et al.
Sathyavathi ChallaSivaKanaka et al.
Lethal prostate cancer (PCa) disproportionately affects African American (AA) men, who experience a higher incidence and earlier onset compared to European American (EA) men, reflecting a persistent biological and clinical disparity. Recent...
CD4+ T-cells sensitize quasi-mesenchymal breast tumors lacking CD73 to anti-CTLA4 immune checkpoint blockade therapy [0.03%]
缺乏CD73的准间质性乳腺癌细胞被CD4+T细胞活化从而敏化对抗CTLA4免疫检查点阻断疗法
Shiney Chandraganti,Caitlyn Sams,Sarthak Sahoo et al.
Shiney Chandraganti et al.
Although immune checkpoint blockade therapy has generated dramatic responses in certain cancer types, breast tumors are largely unresponsive. Epithelial-mesenchymal plasticity leads to the assembly of an immunosuppressive tumor microenviron...