Mitochondrial tRNA-derived fragments as candidate metastasis-modifying RNA [0.03%]
线粒体tRNA衍生片段作为潜在的转移修饰RNA
Katy L Swancutt,R McKinnon Walsh,Sydney Quijano et al.
Katy L Swancutt et al.
How mitochondrial DNA (mtDNA) polymorphisms influence complex phenotypes remains poorly understood. Using Mitochondrial-Nuclear eXchange (MNX) mice, we previously showed that mtDNA single nucleotide polymorphisms (SNP) modify metastasis, ca...
Survival of U.S. Military Service Members with Hodgkin Lymphoma by Post 9/11 Deployment Status [0.03%]
按9·11后部署状态分类的美国现役军人霍奇金淋巴瘤患者的生存状况
Steven Gibson,Sarah Darmon,Wendy Cozen et al.
Steven Gibson et al.
Classic Hodgkin lymphoma (CHL) commonly affects adolescents and young adults (AYAs), including service members (SMs). Impact of deployment on CHL outcomes remains unknown. Tricare beneficiaries diagnosed with CHL from 2001-2022 were identif...
Ex vivo tumor derived organoid pharmacotyping identifies personalized therapeutic options for biliary tract cancer patients [0.03%]
体外肿瘤衍生类器官药效筛选识别胆道癌患者个性化治疗选项
Annie Blair Richardson,Payel Chatterjee,Rachele Rosati et al.
Annie Blair Richardson et al.
Biliary tract cancers (BTCs) pose clinical challenges due to poor chemotherapy response and aggressive disease course. We evaluated patient derived tumor organoid (PDTO) based drug sensitivity testing as a tool to guide therapy. In this mul...
Co-Clinical Evaluation of Synthetic Vitamin D and Chemotherapy in Pancreatic Cancer by Integrated Imaging and Molecular Analyses [0.03%]
基于影像学和分子综合分析的合成维生素D与化疗联合治疗胰腺癌的临床评估研究
Mamta Gupta,Hoon Choi,Thomas Karasic et al.
Mamta Gupta et al.
Purpose: A pilot clinical trial (NCT03519308) was conducted to evaluate perioperative chemotherapy (nab-paclitaxel, gemcitabine, and cisplatin; NGC) plus nivolumab, with or without synthetic vitamin D (paricalcitol) in re...
An Integrated Spatial Multi-Omics Workflow for Sequential RNA and Protein Profiling in FFPE Tumor Tissue [0.03%]
用于福尔马林固定石蜡包埋肿瘤组织的顺序RNA和蛋白质谱整合空间多组学工作流程
Merrin Mary Eapen,Qanber Raza,Lucy Chhuo et al.
Merrin Mary Eapen et al.
Understanding complex cellular niches, such as tertiary lymphoid structures (TLS), requires spatially resolved, multi-omic approaches that link transcriptional states and protein expression levels within individual cells. Here, we present a...
Febuxostat enhances the anti-tumor efficacy of 2-fluoroadenine and 5'-methylthioadenosine in MTAP-deleted cancer [0.03%]
febuxostat增强2-氟腺嘌呤和5'-硫代腺苷在MTAP基因缺失的肿瘤中的抗肿瘤作用
Baiqing Tang,Hyung-Ok Lee,Daniel Krzizike et al.
Baiqing Tang et al.
Homozygous deletion of the methylthioadenosine phosphorylase gene (MTAP) is a frequent genetic alteration in cancer. The MTAP enzyme, which creates adenine from 5'-methylthioadenosine (MTA), is constitutively expressed in all tissues throug...
Combination AURKA and WEE1 inhibition exhibits efficacy in EGFR or pan-ERBB inhibitor resistant head and neck squamous cell carcinoma [0.03%]
AURKA和WEE1联合抑制在EGFR或泛ERBB抑制剂耐药的头颈鳞状细胞癌中的疗效
Flaviane N Silva,Jong Woo Lee,Theodore T Nguyen et al.
Flaviane N Silva et al.
Over 600,000 cases of head and neck squamous cell carcinoma (HNSCC) are diagnosed globally each year. Many HNSCCs overexpress the ERBB family member EGFR, and EGFR inhibitors (EGFRis) and pan-ERBB inhibitors (ERBBis) are clinically active i...
E3 Ubiquitin Ligase Mindbomb1 Is a Novel Negative Regulator of Tumor-Suppressive BMP Signaling [0.03%]
E3泛素连接酶Mindbomb 1是抑癌BMP信号传导通路的新型负调节因子
Charisa L Cottonham,Gloria E Hernandez,Tommy K Cheung et al.
Charisa L Cottonham et al.
Mindbomb1 (MIB1), an E3 ubiquitin ligase required for NOTCH activation, has been identified as a strongly selective cancer dependency in genome-wide loss-of-function screens in over 1000 cancer cell lines. However, MIB1-correlating dependen...
Advancing Prostate Cancer Survivorship Through Transatlantic Consortium Science: The iCCaRE Initiative [0.03%]
国际前列腺癌生存研究:iCCaRE计划
Folakemi T Odedina,Roxana Dronca,Kimlin Tam Ashing et al.
Folakemi T Odedina et al.
Black/African American populations, globally, bear the greatest prostate cancer (CaP) burden compared to other racial/ethnic groups. Addressing CaP disparities in Black men is complex, requiring a patient-centered, community-centric and com...
Metabolic Syndrome, Component Burden, and Incident Gastric Cancer Risk: A Prospective Cohort Study in the UK Biobank [0.03%]
代谢综合征、组分负荷与胃癌发病风险：英国生物银行前瞻性队列研究
Gang-Qiang Wang,Shi-Rui Li,Si-Yu Li et al.
Gang-Qiang Wang et al.
As Helicobacter pylori prevalence declines, understanding the contribution of modifiable systemic factors to gastric cancer (GC) risk becomes increasingly important. We evaluated the association of metabolic syndrome (MetS), its individual ...