Single cell RNA analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathway [0.03%]
Alexander Ferrena,Ranxin Zhang,Jichuan Wang et al.
Alexander Ferrena et al.
Osteosarcoma (OS) is the most common primary pediatric bone malignancy. One promising new target is SKP2, encoding a substrate recognition factor of the SCF E3 ubiquitin ligase that targets p27 for proteasomal degradation, driving cellular ...
Real-world characterization and treatment patterns of patients with desmoid tumors at an academic center in the United States [0.03%]
Chia Jie Tan,Connor Willis,Timothy Bell et al.
Chia Jie Tan et al.
Real-world studies on desmoid tumors (DTs) are limited due to its low incidence. Therefore, we aimed to characterize the patient journey in DTs from diagnosis to treatment at an academic center in the United States. A retrospective cohort s...
Characterization of mitochondrial double-stranded RNA levels in Non-Small Cell Lung Carcinoma [0.03%]
非小细胞肺癌中线粒体双链RNA水平的鉴定
Matthew R Krieger,Sandy Che-Eun S Lee,Ting Fu et al.
Matthew R Krieger et al.
Mitochondrial double-stranded RNA (mtdsRNA) is exported to the cytoplasm when mitochondrial RNA degradation is impaired, serving as a novel damage-associated molecular pattern (DAMP) for mitochondrial stress. Whereas mtdsRNA has been detect...
Predominant Merkel Cell Polyomavirus DNA Detection in Essential Thrombocythemia within Myeloproliferative Neoplasms [0.03%]
在骨髓增生性肿瘤中检测到艾森豪威尔血小板增多症的主要梅尔克细胞多瘤病毒DNA
Dan Liu,Sixuan J Wang,Amanda Macamo et al.
Dan Liu et al.
Acute thrombocythemic myeloproliferative disease in mice has been reported upon introduction of Middle T gene expression of mouse polyomavirus. Merkel cell polyomavirus (MCPyV) is an oncogenic human polyomavirus that accounts for approximat...
Metastasis-associated wound repair promotes reciprocal lung epithelium activation and breast cancer metastatic outgrowth [0.03%]
与转移相关的伤口修复促进肺上皮细胞的相互作用并促进乳腺癌转移生长
Jessica L Christenson,Nicole S Spoelstra,Michelle M Williams et al.
Jessica L Christenson et al.
When tumor cells colonize distant organs during metastasis, they interact extensively with surrounding cells. These interactions often change the behavior of surrounding cell populations which collectively induce a pro-tumor microenvironmen...
Constitutive EGFR activation induced by PTPRR downregulation confers resistance to KRAS inhibitors [0.03%]
PTPRR下调诱导的组成型EGFR活化赋予肿瘤耐受KRAS抑制剂性質
Hiroaki Kanemura,Toshiyuki Takehara,Osamu Maenishi et al.
Hiroaki Kanemura et al.
KRASG12C inhibitors, such as sotorasib, show clinical efficacy for non-small cell lung cancer (NSCLC) positive for the G12C mutations of KRAS, but primary and acquired resistance to these drugs remains a clinical problem. We here show that ...
Pseudogene co-expression networks reveal a robust prognostic signature for pediatric B-ALL survival [0.03%]
伪基因共表达网络可揭示儿童B-急淋预后标志物
Arturo Kenzuke Nakamura-García,Mariike L Kuijjer,Jesús Espinal-Enríquez
Arturo Kenzuke Nakamura-García
Risk classification in B-cell acute lymphoblastic leukemia (B-ALL) remains challenging, even in the era of genomic precision medicine. Current molecular classifiers fail to fully explain the heterogeneity in patient outcomes, suggesting tha...
The KRAS-variant and cetuximab in HPV-positive oropharyngeal cancer - results from the NRG/RTOG 1016 trial [0.03%]
KRAS变异和西妥昔单抗在HPV阳性的口腔癌中疗效的NRG/RTOG 1016试验结果
Joanne B Weidhaas,Jonathan Harris,Maura L Gillison et al.
Joanne B Weidhaas et al.
Purpose: NRG/RTOG 1016 was a phase III non-inferiority trial comparing IMRT + cisplatin versus IMRT + cetuximab for HPV-positive oropharyngeal cancer (OPC) patients. A germline mutation (the KRAS-variant) previously ident...
A phase I study of hydroxychloroquine and suba-itraconazole in men with biochemical relapse of prostate cancer (HITMAN-PC): dose escalation results [0.03%]
羟氯喹和伊曲康唑治疗生化复发前列腺癌的I期临床试验（HITMAN-PC研究）：剂量递增结果报告
Barak Talmor,Stefano Marastoni,Brandon Lau et al.
Barak Talmor et al.
Purpose: Biochemical recurrence (BCR) of prostate cancer (PCa) presents a clinical challenge with limited systemic treatment options beyond androgen deprivation therapy (ADT), which carries significant morbidity. Preclini...
Mechanisms Underlying Cedazuridine-Mediated Enhancement of Oral Decitabine Bioavailability [0.03%]
Cedazuridine改善口服Decitabine生物利用度的机制研究
Nadeen Anabtawi,Thomas Drabison,Alexander F Ham et al.
Nadeen Anabtawi et al.
Decitabine is a DNA hypomethylating agent used in the treatment of patients with myelodysplastic syndromes and acute myeloid leukemia that is administered intravenously due to its poor oral bioavailability. An oral medication containing dec...