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E3 Ubiquitin Ligase Mindbomb1 Is a Novel Negative Regulator of Tumor-Suppressive BMP Signaling

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Mindbomb1 (MIB1), an E3 ubiquitin ligase required for NOTCH activation, has been identified as a strongly selective cancer dependency in genome-wide loss-of-function screens in over 1000 cancer cell lines. However, MIB1-correlating dependencies in these screen... ...