ZRSR1 protects against obesity-associated hepatic lipogenesis independent of minor intron splicing [0.03%]
ZRSR1通过其非主要内含子剪接功能抵抗肥胖相关的肝脏脂质合成
Yinkun Fu,Hongyong Song,Yinglin Han et al.
Yinkun Fu et al.
Minor intron retention resulting from dysregulation of minor intron splicing factors is an emerging risk factor for the metabolic dysfunction-associated steatotic liver disease (MASLD). However, whether impaired expression of these splicing...
Joint effects of residential greenness and genetic susceptibility on type 2 diabetes: a prospective cohort study using satellite-derived Normalized Difference Vegetation Index [0.03%]
基于卫星的Normalized Difference Vegetation Index研究居住地绿化与遗传易感性对2型糖尿病联合效应的前瞻性队列研究
Yonghua Yu,Junru Fan,Qiuyu Cao et al.
Yonghua Yu et al.
Residential greenness has been linked to a reduced risk of type 2 diabetes (T2D), yet whether genetic susceptibility modifies this association remains unclear. Evidence on gene-environment interaction is limited, mainly cross-sectional, and...
Three-dimensional mapping and functional analysis of sympathetic innervation in aortic perivascular adipose tissue [0.03%]
主动脉周围脂肪组织交感神经支配的三维映射及功能分析
Zhao-Ning Wang,Yan-Jue Song,Liang Tan et al.
Zhao-Ning Wang et al.
Perivascular adipose tissue (PVAT) is a critical regulator of vascular homeostasis, and sympathetic nerves play a fundamental role in vascular function. However, the function of PVAT as an intermediary in neurovascular communication remains...
Endothelial CPT2 loss impairs fatty acid oxidation and promotes renal fibrosis [0.03%]
内皮CPT2丢失会损害脂肪酸氧化并促进肾纤维化
Xudong Zhao,Zu-Xi Yu,Brendan M Browne et al.
Xudong Zhao et al.
Mitochondrial OPerA: tuning retrograde signaling and empowering intratumoral cDC1s [0.03%]
线粒体歌剧：调节逆向信号传导并增强瘤内cDC1细胞功能
Bhavana Kushwaha,Ruoning Wang
Bhavana Kushwaha
SLC25A35 carrier endows mitochondrial phosphoenolpyruvate with glyceroneogenesis [0.03%]
SLC25A35基因突变携带者线粒体乙醇酸代谢受损致二羧酸循环与糖异生解偶联
Xinyu Liu,Wei Meng,Xun Huang
Xinyu Liu
Structure-guided design of a PCSK9 epitope vaccine with efficacy against hyperlipidemia and atherosclerosis [0.03%]
结构导向设计出一种治疗高脂血症和动脉粥样硬化的PCSK9表位疫苗
Hongliang Sun,Zhuang Li,Xinli Hu et al.
Hongliang Sun et al.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a central role in regulating low-density lipoprotein cholesterol (LDL-C) levels and has emerged as an attractive target for atherosclerotic cardiovascular disease (ASCVD) therapy. ...
Exercise preserves β-cell function in type 2 diabetes by reshaping intra-islet macrophage-β-cell crosstalk [0.03%]
运动通过重塑胰岛巨噬细胞-β细胞相互作用来维持2型糖尿病患者β细胞功能
Miqi Yang,Yanping Zhou,Qing-Qian Wu et al.
Miqi Yang et al.
Type 2 diabetes (T2D) is characterized by pancreatic islet β-cell dysfunction and systemic insulin resistance, with meta-inflammation playing a critical role in disease progression. As the major type of immune cell population in islets, bo...
CLPTM1L modulates membrane lipid rafts to promote tumor EGFR signaling [0.03%]
CLPTM1L调节细胞膜脂筏促进肿瘤EGFR信号转导
Dejian Pang,Xuan Yang,Xinyao Li et al.
Dejian Pang et al.
The plasma membrane dynamically organizes into specialized lipid domains to sustain cell proliferative signaling, yet the regu-latory mechanisms driving this process, especially during tumor progression, remain poorly understood. Here, we u...