Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut-liver axis [0.03%]
肠-肝轴抗氧化调节：阿克曼氏菌产生的丙酸缓解肝纤维化
Lu Zhang,Jing Chen,Si-Jia Ge et al.
Lu Zhang et al.
The gut commensal bacterium Akkermansia muciniphila (AKK) has emerged as a candidate for treating liver disorders, yet its therapeutic potential in liver fibrosis remains poorly defined. Here, using a carbon tetrachloride (CCl4)-induced mur...
The pathogenic theory of homeostasis threshold deviation (HTD) in wide-range oscillatory physiological parameters: novel perspectives for hypertension and metabolic disease treatment [0.03%]
生理参数波动下的稳态域阈值偏差(HDT)的致病理论：高血压和代谢性疾病的治疗新视角
Wei Sun,Jin-Yu Sun,Xiangqing Kong
Wei Sun
Based on current research in neuroscience, systems biology, and clinical medicine, we propose a novel theoretical concept: the "Homeostasis Threshold Deviation (HTD) Theory of Wide-Range Oscillatory Physiological Parameters". HTD posits tha...
Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time [0.03%]
与烟酰胺类物质保持同步：NADP(H)，被遗忘的维持代谢节律的昼夜节律辅因子
Lauren Palluth,Joseph S Takahashi,Carla B Green
Lauren Palluth
The hierarchical relationship between the core circadian clock of the suprachiasmatic nucleus and peripheral clocks throughout the body is tightly regulated. Nicotinamide adenine dinucleotide phosphate (NADP(H)) is a rhythmic cofactor used ...
Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation [0.03%]
能量压力诱导的PKCζ S-谷氨酰化对LKB1胞浆转位和AMPK激活是必需的
Junjie Fei,Shuhan Yu,Mingzhe Xu et al.
Junjie Fei et al.
Energy stress triggers the activation of AMP-activated protein kinase (AMPK) via phosphorylation mediated by liver kinase B1 (LKB1). A pivotal step during this process is the translocation of protein kinase C zeta (PKCζ) to the nucleus, wh...
Well Met: RIPK1 senses S-adenosyl methionine to ensure cell survival [0.03%]
SAM维持细胞存活的新机制：RIPK1感应SAM水平抑制细胞焦亡
Piyush Sharma,Douglas R Green
Piyush Sharma
The brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway [0.03%]
棕色脂肪细胞衍生的外泌体miR-206-3p通过抑制戊糖磷酸途径减少肝脏脂质合成
Li-Jie Yang,Qiu-Kai Tang,Lei Wang et al.
Li-Jie Yang et al.
Brown adipose tissue (BAT) orchestrates interorgan crosstalk through secreted mediators, including proteins, lipids, and exosomal microRNAs (miRNAs). However, the precise molecular identities and functional contributions of these mediators ...
Zhi Li,Wei Meng,Zihan Gao et al.
Zhi Li et al.
Uric acid (UA) is a key intermediate in purine degradation across diverse organisms, while its accumulation in humans leads to inflammation and gout disease. Aerobic organisms degrade UA via a well-known "oxidative pathway" involving dearom...
Targeting complex IV to alter the tumor microenvironment and boost macrophage antitumor immunity [0.03%]
针对复合体IV以改变肿瘤微环境并增强巨噬细胞的抗肿瘤免疫能力
Thomas Pfefer,Luke A J O&#x;Neill
Thomas Pfefer
Clark et al. showcase that interferons (IFNs) trigger a functional reprogramming of tumor-associated macrophages (TAMs) by downregulating NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (NDUFA4), a key subunit of mitochondrial complex ...
RME-1-associated recycling endosomes participate in vitellogenin secretion in Caenorhabditis elegans [0.03%]
RME-1相关回收内体参与秀丽隐杆线虫卵黄蛋白原的分泌
Chao Zhai,Meng-Qiu Dong
Chao Zhai
Vitellogenins (VITs), the lipoprotein precursors of yolk proteins in Caenorhabditis elegans, are expressed in the intestine, secreted into the pseudocoelom, and ultimately transported into oocytes. However, the mechanism by which VITs are s...
Cryo-EM structure of the human MON1A-CCZ1-RAB7A complex provides insights into nucleotide exchange mechanism [0.03%]
人类MON1A-CCZ1-RAB7A复合物的冷冻电镜结构为核苷酸交换机制提供了见解
Xinna Li,Dan Li,Dan Tang et al.
Xinna Li et al.
Autophagy is a fundamental cellular process, conserved across species from yeast to mammals, that plays a crucial role in maintaining cellular homeostasis. The functionally conserved MON1-CCZ1 (MC1) complex serves as a guanine nucleotide ex...