Intestinal epithelial formyl peptide receptor 2 contributes to intestinal epithelium homeostasis and injury repair by regulating intestinal stem cell and transit-amplifying cell proliferation and differentiation [0.03%]
Shuting Yu,Lele Song,Wunier et al.
Shuting Yu et al.
Intestinal stem cells (ISCs) play critical roles in the self-renewal and regeneration of the intestinal epithelium under physiological conditions and after injury, respectively. However, the underlying mechanisms are not fully understood. I...
Lysosomes contribute to the synthesis of tricarboxylic acid-related metabolites in the hippocampus [0.03%]
Liangliang Kong,Hongying Tan,Xiaoting Zhu et al.
Liangliang Kong et al.
The central nervous system is highly sensitive to energy supply, and the hippocampus operates under sustained metabolic load due to continuous synaptic activity and information processing. Lysosomes couple nutrient status to cellular energe...
Zhihui Zhang,John A Hawley,Min-Dian Li
Zhihui Zhang
Exercise performance in endurance- and power-based events is time-of-day dependent in both humans and rodents. Accordingly, there has been growing interest in determining whether there is an optimal time of day for physical activity that ca...
Age-specific effects of hemoglobin A1c, blood pressure, and cholesterol levels on incident cardiovascular diseases among adults with diabetes in China: a 10-year prospective cohort study [0.03%]
Yue Yin,Xiaojing Jia,Shengli Wu et al.
Yue Yin et al.
Optimal control of hemoglobin A1c (HbA1c), blood pressure, and cholesterol (ABC risk factors) is essential for reducing cardiovascular disease (CVD) risk in individuals with diabetes. However, age-specific contributions of these factors rem...
Integrative omics analysis incorporating cardiovascular magnetic resonance imaging pinpoints potentially druggable plasma proteins for cardiovascular diseases [0.03%]
Weiming Gong,Ping Guo,Lu Liu et al.
Weiming Gong et al.
Despite advances in traditional risk factors for cardiovascular diseases (CVDs), significant residual risk of CVDs remains incompletely captured. Integrative analysis incorporating cardiovascular magnetic resonance imaging (CMR) could facil...
John R Speakman,Sharon E Mitchell
John R Speakman
Calorie restriction (CR) is a nutritional intervention known to delay aging and extend lifespan across a wide range of species, raising the possibility of similar benefits in humans. This apparent universality has been questioned by studies...
Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production [0.03%]
Qiwen Yang,Na Kong,Jing Wu et al.
Qiwen Yang et al.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, typically characterized by irregular menstrual cycles. Our study found that postpartum menstrual cycles were largely restored in PCOS pa...
Hepatocyte-specific DDAH1 regulates fasting-induced hepatic lipid metabolism via modulating FABP1 expression and AMPK/mTOR-mediated autophagy [0.03%]
肝细胞特异性DDAH1通过调节FABP1表达和AMPK/mTOR介导的自噬调控饥饿诱导的肝脏脂质代谢
Kai Luo,Xiyue Shen,Siyu Wang et al.
Kai Luo et al.
Under nutrient deprivation conditions, the liver maintains systemic energy homeostasis by mobilizing lipid reserves, a process often accompanied by hepatic lipid accumulation. Dimethylarginine dimethylaminohydrolase 1 (DDAH1), a key metabol...
Predictive value of 1-hour postprandial SPARC levels on metabolic outcomes from Mediterranean diet adherence: results from a randomized controlled feeding study [0.03%]
地中海饮食依从性受试者餐后1小时SPARC水平对代谢结局预测价值的随机对照喂食研究
Yanru Chen,Mengshan Ni,Yufei Chen et al.
Yanru Chen et al.
Precision nutrition is pivotal to preventing cardiometabolic diseases. However, almost no single blood biomarker capable of predicting the metabolic benefits of specific dietary patterns has yet been identified. Here, we revealed the associ...
Hyaluronidase-1 mediates postprandial suppression of hepatic gluconeogenesis [0.03%]
透明质酸酶-1介导餐后肝糖异生的抑制作用
Xi Chen,Sophie Dogné,Yanru Deng et al.
Xi Chen et al.
Hepatic gluconeogenesis is a critical process that generates glucose from non-carbohydrate precursors during fasting to support vital organs like the brain and red blood cells. Postprandially, this process is rapidly suppressed to allow for...