Combination of proton-pump inhibitor and anti-CD3 F(ab')2 for islet neogenesis and immune modulation in type 1 diabetes [0.03%]
质子泵抑制剂与抗CD3 F(ab')2联合应用促进1型糖尿病的胰岛新生及免疫调节
Tung-Yun Wu,Che-Yi Chen,Michael Chen et al.
Tung-Yun Wu et al.
Introduction: Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of pancreatic β cells. Current insulin therapy does not address autoimmune pathology or restore endogenous β-cell...
Growth factor supportive care for chemotherapy-induced neutropenia suppresses antitumour immunity in checkpoint blockade-responsive pancreatic cancer [0.03%]
粒细胞集落刺激因子通过抑制免疫反应降低免疫检查点治疗胰腺癌的效果
Brendan D Parent,Anthony E Kelly,Megan T Hoffman et al.
Brendan D Parent et al.
Introduction: Growth factors, including granulocyte colony-stimulating factor (G-CSF; pegfilgrastim, filgrastim), are used for prophylaxis or treatment of chemotherapy-induced neutropenia, yet their effects on antitumour ...
Harnessing the duality of regulatory B cells: from identification of characteristic molecules to therapeutic targeting [0.03%]
利用调节性B细胞的双重性的研究：从识别特征分子到靶向治疗
Luman Wang,Ronghua Liu,Yiwei Chu
Luman Wang
The field of immunology is increasingly intersecting with molecular biology, metabolic biology, and neurobiology (Zhu et al, A neuroimmune circuit mediates cancer cachexia-associated apathy. Science 2025;388:eadm8857; Jaschke et al, Gut-to-...
Vaccination against tumour endothelial marker Robo4 inhibits tumour growth [0.03%]
针对肿瘤内皮标记蛋白Robo4的疫苗能够抑制肿瘤生长
Fernanda Escobar-Riquelme,Muhammet Ali Kara,Michael J Price et al.
Fernanda Escobar-Riquelme et al.
Introduction: Targeting tumour antigens is a major challenge in cancer-immunotherapy. We use active vaccination to induce antibodies targeting self-antigen Robo4, which is selectively expressed on tumour vascular endothel...
NLRC5 expression within tumor cells is critical to activate adaptive and innate antitumor immune responses [0.03%]
肿瘤细胞中NLRC5的表达对于激活适应性和先天性抗肿瘤免疫反应是关键的
Akhil Shukla,Mohammad Moradzad,Akouavi Julite Irmine Quenum et al.
Akhil Shukla et al.
Introduction: Tumors downregulate NLRC5 expression to reduce MHC-I and evade CD8+ T cell-mediated killing. Introducing full-length NLRC5 (N5FL) or NLRC5-CIITA chimeric protein (N5CA) can restore tumor immunogenicity. Here...
Extracellular adenosine released by mesenchymal stromal cells from young hosts boosts the antimicrobial activity of neutrophils from aged hosts against Streptococcus pneumoniae [0.03%]
年轻宿主的间充质基质细胞释放的外源性腺苷可增强老化宿主的中性粒细胞对抗肺炎链球菌的抗菌活性
Rania Hassan Mohamed,Michael C Battaglia,Elsa N Bou Ghanem
Rania Hassan Mohamed
Mesenchymal stem cells (MSC) represent a potential target to reverse inflammaging and to halt immunosenescence, as these cells can modulate immune cell responses. Neutrophils, known as polymorphonuclear leukocytes (PMNs), are required for h...
The resilient subset: cancer stem cells at the core of immunotherapy resistance [0.03%]
顽固的亚群：免疫治疗耐药性背后的癌症干细胞
Julián A Gajón,Diego Esperante,Nahuel Ko et al.
Julián A Gajón et al.
Cancer stem cells (CSCs) are a small subset of cells that possess unique characteristics, including the ability to initiate and sustain tumor growth, self-renew, and differentiate into various types of cancer cells. They play a crucial role...
Head-to-head comparison of nuclear imaging approaches to quantify tumor CD8+ T-cell infiltration [0.03%]
头部对比核医学影像方法量化肿瘤CD8+t细胞浸润的方法
Gerwin G W Sandker,René Raavé,Inês F Antunes et al.
Gerwin G W Sandker et al.
Introduction: Many immunotherapies focus on (re)invigorating CD8+ T cell anti-cancer responses. Different nuclear imaging techniques have been developed to measure CD8+ T cell distributions. Comprehensive comparisons of i...
Pharmacokinetics of hyaluronidase-facilitated subcutaneous immunoglobulin 10% in pediatric patients with primary immunodeficiency disease [0.03%]
用于原发性免疫缺陷病儿童患者的透明质酸酶辅助皮下注射10%免疫球蛋白的药代动力学
Zhaoyang Li,Yang Teng,Sharon Russo-Schwarzbaum et al.
Zhaoyang Li et al.
Introduction: Hyaluronidase-facilitated subcutaneous immunoglobulin 10% (fSCIG 10%) is a unique and effective treatment for primary immunodeficiency disease (PID), allowing for less frequent administration than convention...
Chimeric CD3ζ chains containing CD28 signalling motifs enhance antigen-specific IL-2 production and expansion of human TCR-engineered T cells in vitro [0.03%]
嵌合CD3ζ链中包含的CD28信号基序增强人类TCR工程T细胞体外特异性IL-2产生和扩增
Samuel J Burgess,Hans J Stauss,Emma C Morris
Samuel J Burgess
Gene-engineered T-cell products have been developed for immunotherapy to treat cancers, with great success observed in haematological malignancies but limited efficacy in treating solid cancers. TCR-engineered T cells utilize transferred TC...