NLRC5 expression within tumor cells is critical to activate adaptive and innate antitumor immune responses [0.03%]
肿瘤细胞中NLRC5的表达对于激活适应性和先天性抗肿瘤免疫反应是关键的
Akhil Shukla,Mohammad Moradzad,Akouavi Julite Irmine Quenum et al.
Akhil Shukla et al.
Introduction: Tumors downregulate NLRC5 expression to reduce MHC-I and evade CD8+ T cell-mediated killing. Introducing full-length NLRC5 (N5FL) or NLRC5-CIITA chimeric protein (N5CA) can restore tumor immunogenicity. Here...
Extracellular adenosine released by mesenchymal stromal cells from young hosts boosts the antimicrobial activity of neutrophils from aged hosts against Streptococcus pneumoniae [0.03%]
年轻宿主的间充质基质细胞释放的外源性腺苷可增强老化宿主的中性粒细胞对抗肺炎链球菌的抗菌活性
Rania Hassan Mohamed,Michael C Battaglia,Elsa N Bou Ghanem
Rania Hassan Mohamed
Mesenchymal stem cells (MSC) represent a potential target to reverse inflammaging and to halt immunosenescence, as these cells can modulate immune cell responses. Neutrophils, known as polymorphonuclear leukocytes (PMNs), are required for h...
The resilient subset: cancer stem cells at the core of immunotherapy resistance [0.03%]
顽固的亚群：免疫治疗耐药性背后的癌症干细胞
Julián A Gajón,Diego Esperante,Nahuel Ko et al.
Julián A Gajón et al.
Cancer stem cells (CSCs) are a small subset of cells that possess unique characteristics, including the ability to initiate and sustain tumor growth, self-renew, and differentiate into various types of cancer cells. They play a crucial role...
Head-to-head comparison of nuclear imaging approaches to quantify tumor CD8+ T-cell infiltration [0.03%]
头部对比核医学影像方法量化肿瘤CD8+t细胞浸润的方法
Gerwin G W Sandker,René Raavé,Inês F Antunes et al.
Gerwin G W Sandker et al.
Introduction: Many immunotherapies focus on (re)invigorating CD8+ T cell anti-cancer responses. Different nuclear imaging techniques have been developed to measure CD8+ T cell distributions. Comprehensive comparisons of i...
Pharmacokinetics of hyaluronidase-facilitated subcutaneous immunoglobulin 10% in pediatric patients with primary immunodeficiency disease [0.03%]
用于原发性免疫缺陷病儿童患者的透明质酸酶辅助皮下注射10%免疫球蛋白的药代动力学
Zhaoyang Li,Yang Teng,Sharon Russo-Schwarzbaum et al.
Zhaoyang Li et al.
Introduction: Hyaluronidase-facilitated subcutaneous immunoglobulin 10% (fSCIG 10%) is a unique and effective treatment for primary immunodeficiency disease (PID), allowing for less frequent administration than convention...
Chimeric CD3ζ chains containing CD28 signalling motifs enhance antigen-specific IL-2 production and expansion of human TCR-engineered T cells in vitro [0.03%]
嵌合CD3ζ链中包含的CD28信号基序增强人类TCR工程T细胞体外特异性IL-2产生和扩增
Samuel J Burgess,Hans J Stauss,Emma C Morris
Samuel J Burgess
Gene-engineered T-cell products have been developed for immunotherapy to treat cancers, with great success observed in haematological malignancies but limited efficacy in treating solid cancers. TCR-engineered T cells utilize transferred TC...
Overall survival by baseline and on-treatment systemic immune-inflammation index in patients with advanced cancer receiving immune checkpoint inhibitors: a large single-centre cohort study [0.03%]
基线和免疫检查点抑制剂治疗期间的系统性免疫-炎症指数对晚期癌症患者的总生存期的影响：一项大规模单中心队列研究
Oliver John Kennedy,Rebecca Lee,Fiona Blackhall et al.
Oliver John Kennedy et al.
The Systemic Immune-Inflammation Index (SIII; neutrophils/lymphocytes × platelets) is a low-cost biomarker proposed to predict outcomes with immune checkpoint inhibitors (ICIs). This study evaluated associations of baseline and early on-tr...
Neuraminidase A controls pneumococcal recognition and fate: deficiency enhances immune sensing and intracellular survival, while treatment promotes phagocytic clearance [0.03%]
神经氨酸酶A控制肺炎链球菌的识别和命运：缺陷增强免疫感应和胞内存活，而治疗促进吞噬清除
Kristine Farmen,Georgia Yfanti,Fabienne Geers et al.
Kristine Farmen et al.
Streptococcus pneumoniae (pneumococcus) is a leading cause of bacterial meningitis worldwide and is associated with cerebrovascular complications and long-term neurological sequelae. These outcomes are largely driven by an excessive yet ine...
PD-1 inhibitor-induced rheumatic, endocrine, and sarcoidosis-like immune-related adverse events in metastatic melanoma are associated with improved survival and lower corticosteroid exposure [0.03%]
抗PD-1诱导的类风湿、内分泌和肉芽肿性疾病样的免疫相关不良事件与转移性黑色素瘤改善的生存及较低的皮质类固醇暴露相关
Maria Lindén,Hifaa Al Remawi,Anna Fager et al.
Maria Lindén et al.
Introduction: Programmed cell death protein 1 (PD-1) inhibitors improve survival in advanced melanoma but can induce immune-related adverse events (irAEs). IrAEs have been linked to better outcomes. However, it remains un...
Comprehensive spatial and immune profiling of metastatic mismatch repair-deficient colorectal cancer reveals response to immunotherapy [0.03%]
全面的空间和免疫谱分析揭示了错配修复缺陷型转移性结直肠癌对免疫疗法的反应
Ilkyu Park,Hari Kang,Se-Hee Kim et al.
Ilkyu Park et al.
Introduction: Mismatch repair-deficient (dMMR) colorectal cancers (CRCs) exhibit variable clinical responses to immune checkpoint inhibitors (ICIs) despite their high immunogenicity. ...