NLRC5 expression within tumor cells is critical to activate adaptive and innate antitumor immune responses
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Introduction: Tumors downregulate NLRC5 expression to reduce MHC-I and evade CD8+ T cell-mediated killing. Introducing full-length NLRC5 (N5FL) or NLRC5-CIITA chimeric protein (N5CA) can restore tumor immunogenicity. Here, we elu... ...
