The re-emergence of sexually transmissible multidrug resistant Shigella flexneri 3a, England, United Kingdom [0.03%]
英国英格兰引起性传播的多重耐药痢疾杆菌血清型3a卷土重来
Lewis C E Mason,Hannah Charles,Katie Thorley et al.
Lewis C E Mason et al.
Shigellosis is an enteric infection that transmits through the faecal-oral route, which can occur during sex between men who have sex with men (MSM). Between 2009 and 2014, an epidemic of sexually transmissible Shigella flexneri 3a occurred...
The effect of antibiotic selection on collateral effects and evolvability of uropathogenic Escherichia coli [0.03%]
抗生素选择对尿路致病性大肠杆菌的协同效应和进化能力的影响
Beth James,Hishikha Reesaul,Sidra Kashif et al.
Beth James et al.
Trimethoprim is recommended as a first-line treatment of urinary tract infections (UTIs) in the UK. In 2018, 31.4% of Escherichia coli isolated from UTIs in England were trimethoprim-resistant, leading to overreliance on other first and sec...
Modelling the impact of wastewater flows and management practices on antimicrobial resistance in dairy farms [0.03%]
废水流量和管理措施对奶牛场抗生素抗性的影响机制及数学模型研究
Henry Todman,Richard Helliwell,Liz King et al.
Henry Todman et al.
Dairy slurry is a major source of environmental contamination with antimicrobial resistant genes and bacteria. We developed mathematical models and conducted on-farm research to explore the impact of wastewater flows and management practice...
Demographic fluctuations in bloodstream Staphylococcus aureus lineages configure the mobile gene pool and antimicrobial resistance [0.03%]
血流感染的金黄色葡萄球菌谱系的人群波动配置可移动基因库及抗菌药物抗性
Stephanie S R Souza,Joshua T Smith,Michael M Marcovici et al.
Stephanie S R Souza et al.
Staphylococcus aureus in the bloodstream causes high morbidity and mortality, exacerbated by the spread of multidrug-resistant and methicillin-resistant S. aureus (MRSA). We aimed to characterize the circulating lineages of S. aureus from b...
The impact of antibiotics on the gut microbiota of children recovering from watery diarrhoea [0.03%]
抗生素对恢复期水样腹泻儿童肠道菌群的影响
Son-Nam H Le,Chau Nguyen Ngoc Minh,Paola Florez de Sessions et al.
Son-Nam H Le et al.
Infectious diarrhoeal diseases remain a substantial health burden in young children in low- and middle-income countries. The disease and its variable treatment options significantly alter the gut microbiome, which may affect clinical outcom...
Using next generation antimicrobials to target the mechanisms of infection [0.03%]
利用新一代抗菌药物针对感染机制进行靶向治疗
Kavita Gadar,Ronan R McCarthy
Kavita Gadar
The remarkable impact of antibiotics on human health is being eroded at an alarming rate by the emergence of multidrug resistant pathogens. There is a recognised consensus that new strategies to tackle infection are urgently needed to limit...
Interpretable machine learning-based decision support for prediction of antibiotic resistance for complicated urinary tract infections [0.03%]
基于解释型机器学习的复杂尿路感染抗生素耐药性预测决策支持系统
Jenny Yang,David W Eyre,Lei Lu et al.
Jenny Yang et al.
Urinary tract infections are one of the most common bacterial infections worldwide; however, increasing antimicrobial resistance in bacterial pathogens is making it challenging for clinicians to correctly prescribe patients appropriate anti...
Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles [0.03%]
功能上不同的AcrB突变体在不同生活方式的抗生素抗性中占主导地位
Eleftheria Trampari,Filippo Prischi,Attilio V Vargiu et al.
Eleftheria Trampari et al.
Antibiotic resistance is a pressing healthcare challenge and is mediated by various mechanisms, including the active export of drugs via multidrug efflux systems, which prevent drug accumulation within the cell. Here, we studied how Salmone...
Yunjin Lee,Nicole Robbins,Leah E Cowen
Yunjin Lee
Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus genera. As opportunistic pathogens, these fungi are generally ha...
Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism [0.03%]
α-异丙基马来酸合成酶别构调控丧失被确定为抗菌药物耐药机制
Jaryd R Sullivan,Christophe Courtine,Lorne Taylor et al.
Jaryd R Sullivan et al.
Despite our best efforts to discover new antimicrobials, bacteria have evolved mechanisms to become resistant. Resistance to antimicrobials can be attributed to innate, inducible, and acquired mechanisms. Mycobacterium abscessus is one of t...