Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles [0.03%]
功能上不同的AcrB突变体在不同生活方式的抗生素抗性中占主导地位
Eleftheria Trampari,Filippo Prischi,Attilio V Vargiu et al.
Eleftheria Trampari et al.
Antibiotic resistance is a pressing healthcare challenge and is mediated by various mechanisms, including the active export of drugs via multidrug efflux systems, which prevent drug accumulation within the cell. Here, we studied how Salmone...
Yunjin Lee,Nicole Robbins,Leah E Cowen
Yunjin Lee
Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus genera. As opportunistic pathogens, these fungi are generally ha...
Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism [0.03%]
α-异丙基马来酸合成酶别构调控丧失被确定为抗菌药物耐药机制
Jaryd R Sullivan,Christophe Courtine,Lorne Taylor et al.
Jaryd R Sullivan et al.
Despite our best efforts to discover new antimicrobials, bacteria have evolved mechanisms to become resistant. Resistance to antimicrobials can be attributed to innate, inducible, and acquired mechanisms. Mycobacterium abscessus is one of t...
Maria Clarke,Charlotte K Hind,Philip M Ferguson et al.
Maria Clarke et al.
Some antimicrobial peptides (AMPs) have potent bactericidal activity and are being considered as potential alternatives to classical antibiotics. In response to an infection, such AMPs are often produced in animals alongside other peptides ...
A large screen identifies beta-lactam antibiotics which can be repurposed to target the syphilis agent [0.03%]
一块大型屏幕识别出可以被重新用于靶向梅毒病原体的β-内酰胺类抗生素
Kathryn A Hayes,Jules M Dressler,Steven J Norris et al.
Kathryn A Hayes et al.
Syphilis, caused by the spirochete Treponema pallidum subsp. pallidum (hereafter called T. pallidum), is re-emerging as a worldwide sexually transmitted infection. A single intramuscular dose of benzathine penicillin G is the preferred syph...
Going to extremes: progress in exploring new environments for novel antibiotics [0.03%]
极端求索：抗生素新作用环境研究进展
The discoveries of penicillin and streptomycin were pivotal for infection control with the knowledge subsequently being used to enable the discovery of many other antibiotics currently used in clinical practice. These valuable compounds are...
Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance [0.03%]
靶向不动杆菌baumannii抗性结节分裂型外排泵转录调节物以对抗抗菌药物耐药性
Regulatory elements controlling gene expression fine-tune bacterial responses to environmental cues, including antimicrobials, to optimize survival. Acinetobacter baumannii, a pathogen notorious for antimicrobial resistance, relies on effic...