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The effect of antibiotic selection on collateral effects and evolvability of uropathogenic Escherichia coli

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Trimethoprim is recommended as a first-line treatment of urinary tract infections (UTIs) in the UK. In 2018, 31.4% of Escherichia coli isolated from UTIs in England were trimethoprim-resistant, leading to overreliance on other first and second-line antibiotics... ...