Antibiotic resistance and virulence shape the population of E. coli from diseased calves in Wallonia, Belgium [0.03%]
抗生素抗性及毒力塑造了比利时瓦隆地区病牛犊中的大肠杆菌群体
Virginie Guérin,Nicolas Cabanel,Gan Min Marissa Diana Meijer et al.
Virginie Guérin et al.
Escherichia coli is a major cause of deadly infections in calves. As surveillance in livestock is mainly performed on carriage isolates, factors driving the dissemination of E. coli infecting calves remain largely unknown. Here, we analyzed...
Kåre Mølbak,Anders Rhod Larsen,Ute Wolff Sönksen et al.
Kåre Mølbak et al.
Researchers and decision makers repeatedly highlight the need to apply a holistic approach in the fight against antimicrobial resistance (AMR). Nonetheless, current systems for surveillance of AMR in foodborne infections tend to prioritize ...
β-lactamase-mediated hydrolysis of cloxacillin increases tolerance in Escherichia coli [0.03%]
β-内酰胺酶介导的克林霉素水解增加了大肠杆菌的耐受性
Nora C Brüchle,Kees T Veldman,Quillan Dijkstra et al.
Nora C Brüchle et al.
Antimicrobial resistance is a global health threat, partly driven by the spread of extended-spectrum β-lactamase (ESBL)-producing bacteria. The use of β-lactam antibiotics in healthcare and agriculture contributes to this emergence. The ...
Escalating burden and mortality of carbapenem-resistant Klebsiella pneumoniae species complex infections in Bangladeshi infants [0.03%]
碳青霉烯耐药的克雷伯菌属复杂感染在孟加拉婴儿中负担加重和死亡率升高
Yogesh Hooda,Arif Mohammad Tanmoy,Naito Kanon et al.
Yogesh Hooda et al.
Klebsiella pneumoniae infections in young infants are an escalating threat in low- and middle-income countries, yet robust longitudinal data integrating hospital burden, clinical outcomes, antimicrobial resistance, and genomics remains scar...
Targeting bacterial influx pathways to defeat antibiotic resistance: fluorinated glucose-6-phosphate analogues revive fosfomycin efficacy [0.03%]
瞄准细菌流入途径以克服抗生素抗性：氟化葡萄糖-6-磷酸类似物使fosfomycin疗效复苏
Kirsty Alexandra Teahan,Akhilesh Kumar Chaurasia,Joohyun Lee et al.
Kirsty Alexandra Teahan et al.
Current adjuvant strategies to combat antimicrobial resistance such as β-lactamase inhibitors and efflux pump blockers prevent antibiotic degradation or export. We introduce a fundamentally different approach: exploiting bacterial nutrient...
Isw2-mediated chromatin remodeling governs antifungal tolerance and heteroresistance in Candida albicans [0.03%]
钙保护子Isw2介导的染色质重塑调控白色念珠菌的抗真菌耐受性和异源性耐药性
Maria Juliana Mantilla,Faïza Tebbji,Antony T Vincent et al.
Maria Juliana Mantilla et al.
Antifungal tolerance, unlike resistance, allows cells to grow slowly at concentrations above the minimum inhibitory concentration. While resistance mechanisms are well characterized, the pathways underlying tolerance remain elusive. Here, w...
Overcoming methicillin resistance in Staphylococcus aureus via metal ion disruption of bacterial metabolism [0.03%]
金属离子干扰细菌代谢以克服金黄色葡萄球菌对苯唑西林的耐药性
Ella K Macbeth,Francesca Todd Rose,Chen-Yi Cheung et al.
Ella K Macbeth et al.
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health threat due to both extensive antimicrobial resistance and immune evasion capabilities, necessitating alternative therapeutic strategies. Disruption of bacteri...
Enrichment risk and drivers of manure-derived antibiotic resistance genes in black soldier fly larval gut [0.03%]
黑 SOLDIER FLY 幼虫肠道中抗生素抗性基因的富集风险及其驱动因素——以粪便为来源为例
Yiwen Yang,Yanhong Guo,Tong Xu et al.
Yiwen Yang et al.
Black soldier fly larvae (BSFL) are promising for converting animal manure into protein; however, the risk of antibiotic resistance gene (ARG) enrichment in the larval gut during this process remains unclear. Here, we employed metagenomic a...
Increased temperature selects for antibiotic resistance genes in a model aquatic ecosystem [0.03%]
升温选择了一种模型水生生态系统中的抗生素抗性基因
Emma Bousquet,Sabine Favre-Bonté,Thibault Meyer et al.
Emma Bousquet et al.
There is a rising concern that temperature increases associated with climate change might select for antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in aquatic ecosystems, although the extent of this phenomenon re...
National genomic surveillance reveals global plasmid and chromosomal dissemination routes of blaNDM-1 [0.03%]
国家范围内的基因组监测揭示了blaNDM-1的质粒和染色体传播路线
Ricardo Gutiérrez,Manuel Ramírez-Cardoce,Tábata Elizondo-Alvarez et al.
Ricardo Gutiérrez et al.
The global spread of New Delhi metallo-β-lactamase (NDM)-producing Gram-negative bacteria poses a major threat to healthcare systems worldwide, yet the processes driving their long-term establishment at national scales remain poorly unders...