Absence of gut microbiota restoration following meropenem treatment in a systemic infection model [0.03%]
美罗培南治疗系统性感染小鼠后的肠道微生物群无法恢复至初始状态
Filipe Moura Ribeiro,Camila Fontoura Acosta Ribeiro,Elizabete de Souza Cândido et al.
Filipe Moura Ribeiro et al.
Antibiotics have been shown to have unintended effects on the host by disrupting the beneficial microbiota. In this study, we explored and longitudinally monitored microbiota during and after antibiotic treatment for infection. We induced a...
Risk of multidrug resistance in Escherichia coli associated with routine antimicrobial prophylaxis on pig farms [0.03%]
猪场常规抗生素预防用药导致大肠杆菌多重耐药的风险
Ryohei Toya,Miki Okuno,Yosuke Sasaki et al.
Ryohei Toya et al.
Although extensively studied, the association between antimicrobial usage and the emergence of antimicrobial resistance (AMR) in livestock still has unresolved aspects. This study analyzed the genomes of 195 Escherichia coli strains from pi...
A systematic review of antimicrobial resistance transmission inferences at the human-livestock interface in Africa [0.03%]
非洲人畜共生界面抗微生物药物耐药性传播的系统评价
Frank Chilanga,Keneth I Kasozi,Stella Mazeri et al.
Frank Chilanga et al.
The transmission of antibiotic-resistant bacteria across multi-species networks is a contributor to the global challenge of antimicrobial resistance (AMR). AMR transmission inferencing, a retrospective process, is critical for refining the ...
Beyond breakpoint - reconceptualising AMR as a symptom of planetary stress [0.03%]
超越转折点——将抗生素耐药性重新概念化为地球压力的征兆
Claas Kirchhelle,Adam P Roberts
Claas Kirchhelle
Impact of stereochemical replacement on activity and selectivity of membrane-active antibacterial and antifungal cyclic peptides [0.03%]
立体异构替换对膜活性抗菌和抗真菌环肽的作用和选择性的影响
Sandeep Lohan,Anastasia G Konshina,Eman H M Mohammed et al.
Sandeep Lohan et al.
Herein, we report a library of 7-mer macrocyclic peptides designed by systematically replacing one, multiple, or all L-amino acids with their D-isomers in our previously identified hit compounds. Lead peptides, 15c and 16c, showed broad-spe...
Defining the mechanism of action of the nitrofuranyl piperazine HC2210 against Mycobacterium abscessus [0.03%]
硝噻嗪HC2210抑制胞囊性分枝杆菌的作用机制研究
Ifeanyichukwu E Eke,Bassel J Abdalla,Soledad Soverina et al.
Ifeanyichukwu E Eke et al.
Mycobacterium abscessus (Mab) has intrinsic resistance to diverse classes of antibiotics, making this non-tuberculous mycobacterial (NTM) infection challenging to treat. Three nitrofuranyl piperazines-HC2209, HC2210, and HC2211-were previou...
Current economic and regulatory challenges in developing antibiotics for Gram-negative bacteria [0.03%]
当前针对革兰氏阴性菌抗生素的研发面临到的经济及监管挑战
Nupur Gargate,Mark Laws,Khondaker Miraz Rahman
Nupur Gargate
Antimicrobial resistance (AMR) is a serious global threat projected to cause 10 million deaths annually by 2050. Antibiotics are becoming ineffective, leading to poor health outcomes and economic burden. Despite the urgent need, scientific,...
Strategies and efforts in circumventing the emergence of antiviral resistance against conventional antivirals [0.03%]
针对传统抗病毒药物诱导的抗药性产生的规避策略和努力方向研究进展
Daryl Zheng Hao Aw,Denzel Xugeng Zhang,Marco Vignuzzi
Daryl Zheng Hao Aw
Antiviral resistance stemming from rapid viral evolution and adaptation is a major challenge faced in treating viral infections. Here, we describe the mechanisms and factors underlying antiviral resistance and their implications to future d...
Convergent evolution of antibiotic resistance mechanisms between pyrrolobenzodiazepines and albicidin in multidrug resistant Klebsiella pneumoniae [0.03%]
产生吡咯并苯二氮平和白霉素抗性机制的多重耐药肺炎克雷伯菌的汇聚进化
Yasmin M Surani,Matthew E Wand,Pietro Picconi et al.
Yasmin M Surani et al.
Pyrrolobenzodiazepines (PBDs) containing C8-linked aliphatic heterocycles have been developed as a new class of potent antibacterial compounds. They are active against multidrug resistant Gram-negative pathogens, including Klebsiella pneumo...
Antibiotic potentiators as a promising strategy for combating antibiotic resistance [0.03%]
抗生素增效剂在对抗抗生素耐药性方面的前景策略
Jiddu Joseph,Sanya Boby,Shankumar Mooyottu et al.
Jiddu Joseph et al.
Antimicrobial resistance (AMR) poses a critical global health challenge. It arises from pathogens' resistance to antibiotics due to misuse, overuse, and insufficient regulation. As new antibiotics emerge slowly, antibiotic potentiators can ...