Impact of stereochemical replacement on activity and selectivity of membrane-active antibacterial and antifungal cyclic peptides
{{output}}
Herein, we report a library of 7-mer macrocyclic peptides designed by systematically replacing one, multiple, or all L-amino acids with their D-isomers in our previously identified hit compounds. Lead peptides, 15c and 16c, showed broad-spectrum activity again... ...
