Valeriia Ladyhina,Susanna Sternberg-Lewerin,Axel Sannö et al.
Valeriia Ladyhina et al.
We conducted a longitudinal profiling of environmental resistomes and microbiomes from ten Swedish pig farms in a low-antimicrobial usage context. Samples were collected from pig pen environments and analysed using shotgun metagenomic seque...
Argyrin B exhibits potent therapeutic efficacy in a Clostridioides difficile-infection mouse model while preserving microbiota functionality [0.03%]
Agryrin B在艰难梭菌感染小鼠模型中表现出显著的治疗效果同时保持微生物组功能完整性
Sari Rasheed,Katrin Ehrhardt,Ahmed Mohamed Mostafa Abdrabou et al.
Sari Rasheed et al.
Clostridioides difficile infection (CDI) remains a leading cause of antibiotic-associated diarrhoea, with high recurrence rates and limited treatment options that preserve gut microbiota. Current treatments, including vancomycin, further di...
Combining Evolutionary Steering and Coevolutionary Phage Training to Generate Predictable Phage-Antibiotic Synergy [0.03%]
结合使用进化引导和协同进化噬菌体训练生成可预测的噬菌体-抗生素协同作用
Nehme Lahoud,Sweetzel D Labador,Mrudula Sane et al.
Nehme Lahoud et al.
The rapid rise of multidrug-resistant bacterial pathogens has renewed interest in bacteriophage therapy, yet bacterial resistance to phages can evolve rapidly. Two evolutionary strategies have been proposed to address this challenge: coevol...
Palmitoleic acid drives gentamicin influx to outpace aminoglycoside-modifying enzymes and overcome resistance [0.03%]
棕榈油酸驱动庆大霉素流入以克服修饰酶介导的耐药性
Jamie D Liu,Iris M McClain,James R Manning th et al.
Jamie D Liu et al.
Rising antibiotic resistance causes >700,000 deaths annually and could reach ~10 million by 2050. Because the development of new antibiotics lags behind resistance, strategies that restore the activity of approved drugs are urgently needed....
Near pan-β-lactam resistance in NDM-producing Escherichia coli with PBP3 insertions is overcome by dual PBP2/PBP3 inhibition [0.03%]
PBP3插入引起的NDM产生型泛β-内酰胺耐药的产ESBL的大肠埃希菌可通过双靶点（PBP2和PBP3）抑制剂克服
Jackson V Watkins,Peter A Smith,Ryan T Cirz et al.
Jackson V Watkins et al.
Preferred therapies for NDM-producing E. coli include PBP3-targeting antibiotics. However, the global spread of amino acid insertions in PBP3 (PBP3i) among NDM-producing E. coli can compromise these antibiotics, causing near pan-β-lactam r...
Sequence type-associated carbapenemase genes in sewage-derived Klebsiella pneumoniae and characterization of a tigecycline-resistant ST34 strain [0.03%]
来源于污水的肺炎克雷伯菌中的序列型碳青霉烯酶基因及ST34耐替加环素株的表征
Jundong Zhu,Min Fu,Li Xiang et al.
Jundong Zhu et al.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a high-priority pathogen that severely limits clinical treatment options. Sewage systems serve as critical interfaces for the dissemination of antimicrobial resistance (AMR). However, the...
Low-cost approaches for detecting antimicrobial resistance in bacterial infections in resource-limited settings: a scoping review [0.03%]
低资源环境下检测细菌感染抗微生物药物耐药性的低成本方法：系统综述
David J Roach,Fiorella Krapp,Shriya Bhat et al.
David J Roach et al.
Antimicrobial resistance (AMR) poses a growing global threat, with low- and middle-income countries (LMICs) bearing a disproportionate burden of resistant infections. Detection of resistance is critical for guiding treatment, enabling stewa...
A cell surface transporter mediates phenanthridine resistance in African trypanosomes [0.03%]
非洲锥虫中一种细胞表面转运蛋白介导菲喃啶耐药性
Pieter C Steketee,Marzuq A Ungogo,Edith Paxton et al.
Pieter C Steketee et al.
African animal trypanosomosis poses a significant threat to livestock health and agricultural productivity across sub-Saharan Africa. Isometamidium chloride is the only available drug that is both prophylactic and curative. Despite sustaine...
Forward genetics reveals microsporidian drug targets and recombination-based resistance [0.03%]
正向遗传学揭示了微孢子虫的药物靶点和基于重组的耐药性
Qingyuan Huang,Xianzhi Meng,Winnie Zhao et al.
Qingyuan Huang et al.
Microsporidia are diverse intracellular fungal parasites of humans and agriculturally important animals. Several inhibitors have been characterized, but their microsporidian targets and the mechanisms of resistance evolution remain unknown....
Disconnects between knowledge and practice in antimicrobial resistance stewardship: findings from Vietnam's National AMR survey [0.03%]
抗菌药物耐药性管理中知识与实践脱节：越南全国AMR调查结果
Bach Xuan Tran,Duc Anh Ha,Ngoc Anh Thu Nguyen et al.
Bach Xuan Tran et al.
Antimicrobial resistance (AMR) poses a critical public health challenge, particularly in low- and middle-income countries such as Vietnam. Assessing healthcare professionals' knowledge, attitudes, and practices (KAP) is vital to track progr...