A cell surface transporter mediates phenanthridine resistance in African trypanosomes [0.03%]
非洲锥虫中一种细胞表面转运蛋白介导菲喃啶耐药性
Pieter C Steketee,Marzuq A Ungogo,Edith Paxton et al.
Pieter C Steketee et al.
African animal trypanosomosis poses a significant threat to livestock health and agricultural productivity across sub-Saharan Africa. Isometamidium chloride is the only available drug that is both prophylactic and curative. Despite sustaine...
Forward genetics reveals microsporidian drug targets and recombination-based resistance [0.03%]
正向遗传学揭示了微孢子虫的药物靶点和基于重组的耐药性
Qingyuan Huang,Xianzhi Meng,Winnie Zhao et al.
Qingyuan Huang et al.
Microsporidia are diverse intracellular fungal parasites of humans and agriculturally important animals. Several inhibitors have been characterized, but their microsporidian targets and the mechanisms of resistance evolution remain unknown....
Disconnects between knowledge and practice in antimicrobial resistance stewardship: findings from Vietnam's National AMR survey [0.03%]
抗菌药物耐药性管理中知识与实践脱节：越南全国AMR调查结果
Bach Xuan Tran,Duc Anh Ha,Ngoc Anh Thu Nguyen et al.
Bach Xuan Tran et al.
Antimicrobial resistance (AMR) poses a critical public health challenge, particularly in low- and middle-income countries such as Vietnam. Assessing healthcare professionals' knowledge, attitudes, and practices (KAP) is vital to track progr...
Antibiotic resistance and virulence shape the population of E. coli from diseased calves in Wallonia, Belgium [0.03%]
抗生素抗性及毒力塑造了比利时瓦隆地区病牛犊中的大肠杆菌群体
Virginie Guérin,Nicolas Cabanel,Gan Min Marissa Diana Meijer et al.
Virginie Guérin et al.
Escherichia coli is a major cause of deadly infections in calves. As surveillance in livestock is mainly performed on carriage isolates, factors driving the dissemination of E. coli infecting calves remain largely unknown. Here, we analyzed...
Kåre Mølbak,Anders Rhod Larsen,Ute Wolff Sönksen et al.
Kåre Mølbak et al.
Researchers and decision makers repeatedly highlight the need to apply a holistic approach in the fight against antimicrobial resistance (AMR). Nonetheless, current systems for surveillance of AMR in foodborne infections tend to prioritize ...
β-lactamase-mediated hydrolysis of cloxacillin increases tolerance in Escherichia coli [0.03%]
β-内酰胺酶介导的克林霉素水解增加了大肠杆菌的耐受性
Nora C Brüchle,Kees T Veldman,Quillan Dijkstra et al.
Nora C Brüchle et al.
Antimicrobial resistance is a global health threat, partly driven by the spread of extended-spectrum β-lactamase (ESBL)-producing bacteria. The use of β-lactam antibiotics in healthcare and agriculture contributes to this emergence. The ...
Escalating burden and mortality of carbapenem-resistant Klebsiella pneumoniae species complex infections in Bangladeshi infants [0.03%]
碳青霉烯耐药的克雷伯菌属复杂感染在孟加拉婴儿中负担加重和死亡率升高
Yogesh Hooda,Arif Mohammad Tanmoy,Naito Kanon et al.
Yogesh Hooda et al.
Klebsiella pneumoniae infections in young infants are an escalating threat in low- and middle-income countries, yet robust longitudinal data integrating hospital burden, clinical outcomes, antimicrobial resistance, and genomics remains scar...
Targeting bacterial influx pathways to defeat antibiotic resistance: fluorinated glucose-6-phosphate analogues revive fosfomycin efficacy [0.03%]
瞄准细菌流入途径以克服抗生素抗性：氟化葡萄糖-6-磷酸类似物使fosfomycin疗效复苏
Kirsty Alexandra Teahan,Akhilesh Kumar Chaurasia,Joohyun Lee et al.
Kirsty Alexandra Teahan et al.
Current adjuvant strategies to combat antimicrobial resistance such as β-lactamase inhibitors and efflux pump blockers prevent antibiotic degradation or export. We introduce a fundamentally different approach: exploiting bacterial nutrient...
Isw2-mediated chromatin remodeling governs antifungal tolerance and heteroresistance in Candida albicans [0.03%]
钙保护子Isw2介导的染色质重塑调控白色念珠菌的抗真菌耐受性和异源性耐药性
Maria Juliana Mantilla,Faïza Tebbji,Antony T Vincent et al.
Maria Juliana Mantilla et al.
Antifungal tolerance, unlike resistance, allows cells to grow slowly at concentrations above the minimum inhibitory concentration. While resistance mechanisms are well characterized, the pathways underlying tolerance remain elusive. Here, w...
Overcoming methicillin resistance in Staphylococcus aureus via metal ion disruption of bacterial metabolism [0.03%]
金属离子干扰细菌代谢以克服金黄色葡萄球菌对苯唑西林的耐药性
Ella K Macbeth,Francesca Todd Rose,Chen-Yi Cheung et al.
Ella K Macbeth et al.
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health threat due to both extensive antimicrobial resistance and immune evasion capabilities, necessitating alternative therapeutic strategies. Disruption of bacteri...