Near pan-β-lactam resistance in NDM-producing Escherichia coli with PBP3 insertions is overcome by dual PBP2/PBP3 inhibition
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Preferred therapies for NDM-producing E. coli include PBP3-targeting antibiotics. However, the global spread of amino acid insertions in PBP3 (PBP3i) among NDM-producing E. coli can compromise these antibiotics, causing near pan-β-lactam resistance. This stud... ...
