Breaking the 'rule-of-five' to access bridged bicyclic heteroaromatic bioisosteres [0.03%]
突破“五倍规则”获得桥环并环杂芳烃生物电子等排体
Ze-Xin Zhang,KaiChen Shu,Michael J Tilby et al.
Ze-Xin Zhang et al.
Bioisosteric replacement of aromatic and heteroaromatic rings with bridged bicyclic hydrocarbons is an important strategy in drug discovery. Intramolecular [2+2] cycloadditions of unconjugated dienes can provide a route to such motifs but a...
Electrochemical oxidation enables aromatic C-H amination with dual mechanisms [0.03%]
电化学氧化活化偶氮键实现芳烃C-H氨化反应Dual机制合成NH基团
Griffin Stewart,Eva Maria Alvarez,Chris Rapala et al.
Griffin Stewart et al.
The selective amination of aromatic C-H bonds is a powerful strategy to access aryl amines, which offer functionalities used in many pharmaceuticals and agrochemicals. Despite advances in the field, a general platform for the direct, select...
Mechanically interlocked monolayer and bilayer two-dimensional polymers with high elastic modulus [0.03%]
高弹性模量的机械互锁单层和双层二维聚合物
Ye Yang,André Knapp,David Bodesheim et al.
Ye Yang et al.
Two-dimensional polymers (2DPs), comprising mono- or multilayer covalent polymeric networks with long-range order in two orthogonal directions, are of considerable interest due to their unique physicochemical properties. However, achieving ...
Oxygen migration into carbon-carbon single bonds by photochemical oxidation [0.03%]
光化学氧化条件下氧向碳碳单键的迁移现象研究
Cade A MacAllister,Caitlin R Lacker,Matthieu F Maciejewski et al.
Cade A MacAllister et al.
The editing of organic molecules through single-atom modification is an enabling capability for medicinal chemistry. Although several examples of single-atom insertions into the carbon-carbon double bonds of unsaturated aromatic ring system...
Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion [0.03%]
通过二氧化碳阴性自由基的热生成进行还原型自由基链引发反应
Ethan R X Lim,Bradley D Cooper,Muralidharan Shanmugam et al.
Ethan R X Lim et al.
Radical chain initiation strategies are fundamental to the synthesis of small molecule drugs and macromolecular materials. Modern methods for initiation through one-electron reduction are largely dominated by photo- and electrochemistry but...
Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes [0.03%]
二级钯催化未活化烯烃环丙烷化的 ambiphile：烷基磺酰氟的应用及硫代替代物的发现
Yilin Cao,Warabhorn Rodphon,Turki M Alturaifi et al.
Yilin Cao et al.
Here we present the ambiphilic reactivity of alkyl sulfonyl fluorides in the stereoselective synthesis of diverse cyclopropanes from olefins, under palladium(II) catalysis. The sulfonyl fluoride functionality serves as both an acidifying gr...
Nickel-mediated aerobic C(sp2)-nucleophile coupling reactions for late-stage diversification of aryl electrophiles [0.03%]
镍介导的分子内/内交叉偶联反应实现芳基亲电试剂晚期结构多样化研究
Dipankar Das,Long P Dinh,Ryan E Smith et al.
Dipankar Das et al.
The structural diversification of pharmaceutically relevant compounds presents unique challenges to catalytic methodologies that have been developed and optimized on simpler substrates that lack drug-like complexity. Herein, we report a gen...
Direct access to a neutral alumene via CO reduction by a dialane and further CO homologation [0.03%]
通过二烷直接访问中性 alumene 并进一步进行CO同系化反应
John A Kelly,Arseni Kostenko,Shigeyoshi Inoue
John A Kelly
Multiple bonds between heavy elements have been shown to be not only stable but also offer divergent reactivity. Accordingly, there has been a drive in research to isolate such species. Here we report on the synthesis of a compound containi...
Achyut R Gogoi,Ángel Rentería-Gómez,Tong-De Tan et al.
Achyut R Gogoi et al.
Transition metal-catalysed difunctionalization of alkenes enables the rapid construction of complex molecules by converting a flat C(sp 2)-C(sp 2) π-fragment to form a three-dimensional structure with neighbouring sp 3-hybridized carbons a...
Anqi Zhang,Spencer Zhao,Jonathan Tyson et al.
Anqi Zhang et al.
Cells execute remarkable functions using biopolymers synthesized from natural building blocks. Engineering cells to leverage the vast array of synthesizable abiotic polymers could provide enhanced or entirely new cellular functions. In this...