Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp3)-H bonds with dihaloarenes using palladium catalysis
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Methylene-selective C-H functionalization at distal positions is a challenge that remains to be addressed in the field of Pd(II) catalysis. We have previously reported a ligand enabled β, γ-C-H coupling with dihaloarenes for the synthesis of benzocyclobutene... ...
