Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion [0.03%]
通过二氧化碳阴性自由基的热生成进行还原型自由基链引发反应
Ethan R X Lim,Bradley D Cooper,Muralidharan Shanmugam et al.
Ethan R X Lim et al.
Radical chain initiation strategies are fundamental to the synthesis of small molecule drugs and macromolecular materials. Modern methods for initiation through one-electron reduction are largely dominated by photo- and electrochemistry but...
Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes [0.03%]
二级钯催化未活化烯烃环丙烷化的 ambiphile：烷基磺酰氟的应用及硫代替代物的发现
Yilin Cao,Warabhorn Rodphon,Turki M Alturaifi et al.
Yilin Cao et al.
Here we present the ambiphilic reactivity of alkyl sulfonyl fluorides in the stereoselective synthesis of diverse cyclopropanes from olefins, under palladium(II) catalysis. The sulfonyl fluoride functionality serves as both an acidifying gr...
Nickel-mediated aerobic C(sp2)-nucleophile coupling reactions for late-stage diversification of aryl electrophiles [0.03%]
镍介导的分子内/内交叉偶联反应实现芳基亲电试剂晚期结构多样化研究
Dipankar Das,Long P Dinh,Ryan E Smith et al.
Dipankar Das et al.
The structural diversification of pharmaceutically relevant compounds presents unique challenges to catalytic methodologies that have been developed and optimized on simpler substrates that lack drug-like complexity. Herein, we report a gen...
Direct access to a neutral alumene via CO reduction by a dialane and further CO homologation [0.03%]
通过二烷直接访问中性 alumene 并进一步进行CO同系化反应
John A Kelly,Arseni Kostenko,Shigeyoshi Inoue
John A Kelly
Multiple bonds between heavy elements have been shown to be not only stable but also offer divergent reactivity. Accordingly, there has been a drive in research to isolate such species. Here we report on the synthesis of a compound containi...
Achyut R Gogoi,Ángel Rentería-Gómez,Tong-De Tan et al.
Achyut R Gogoi et al.
Transition metal-catalysed difunctionalization of alkenes enables the rapid construction of complex molecules by converting a flat C(sp 2)-C(sp 2) π-fragment to form a three-dimensional structure with neighbouring sp 3-hybridized carbons a...
Anqi Zhang,Spencer Zhao,Jonathan Tyson et al.
Anqi Zhang et al.
Cells execute remarkable functions using biopolymers synthesized from natural building blocks. Engineering cells to leverage the vast array of synthesizable abiotic polymers could provide enhanced or entirely new cellular functions. In this...
Yuchong Yang,Tanya K Ronson,Paula C P Teeuwen et al.
Yuchong Yang et al.
Interwoven molecular structures underpin the functions of many biomolecules, yet synthesizing artificial topologically complex structures in high yield remains challenging. Here we describe a streamlined, high-yield one-pot synthesis of kno...
Qing Zhang,Nils J Flodén,Yongliang Zhang et al.
Qing Zhang et al.
The development of a general strategy for stereospecific construction of every type of glycosidic linkage remains a much sought-after yet unrealized goal. Such a strategy would be particularly useful in the context of complex glycan synthes...
Synthesis and reactivity of nitrogen-containing strained cyclic 1,2,3-trienes [0.03%]
含氮环应变1,2,3-三烯的合成与反应性研究
Dominick C Witkowski,Daniel W Turner,Ana S Bulger et al.
Dominick C Witkowski et al.
Cyclic 1,2,3-trienes are a class of intermediates that confine a functional group with a preferred linear geometry into a ring. When the ring is sufficiently small, the 1,2,3-triene geometry becomes bent, leading to substantial strain and h...
Luca McDermott,Zach G Walters,Allison M Clark et al.
Luca McDermott et al.
π-bonds are typically associated with well-defined arrangements of atoms. However, when the arrangement of atoms associated with these bonds becomes geometrically distorted, heightened reactivity is seen, enabling a wide range of transform...