Lung adenocarcinoma harboring uncommon EGFR exon 19 deletion L747_T751del and in cis K754E mutation: a case report and literature review [0.03%]
罕见EGFR 19外显子不常见突变L747-T751del和顺式K754E突变型肺腺癌一例及文献复习
Chao Li,Runze Liu,Pei Li et al.
Chao Li et al.
E746_A750del, the most common and predominant EGFR exon 19 deletion in non-small cell lung cancer, shows excellent sensitivity to EGFR tyrosine kinase inhibitors. However, other uncommon EGFR exon 19 deletions show varying responses to EGFR...
Changes in peripheral blood B cell levels predict overall survival in patients with advanced liver cancer treated with immune target inhibitors [0.03%]
外周血B细胞水平变化可预测免疫靶向抑制剂治疗晚期肝癌患者总生存期
Shifeng Cheng,Jing Tang,Yafeng Mo et al.
Shifeng Cheng et al.
PD-1 inhibitors show efficacy in hepatocellular carcinoma (HCC), yet overall outcomes remain poor. In this retrospective study of 258 advanced HCC patients treated between 2019 and 2024, peripheral blood B-cell dynamics were evaluated. Pati...
Cell cycle-related biomarker lineage promotes the malignant progression of recurrent IDH wild-type glioma [0.03%]
细胞周期相关生物标志物谱系促进IDH野生型复发胶质瘤恶性进展
Jianbao Xu,Ying Zhang,Wenhua Fan et al.
Jianbao Xu et al.
Background: Glioma is the most common primary brain tumor in adults, malignant progression and recurrence are inevitable. Although mechanisms of glioma development and progression have been demonstrated, the underlying dr...
Xilin Cui,Ziyi Wang,Chengkang Wang et al.
Xilin Cui et al.
Machine learning-based coagulation-related signature for predicting the prognosis and therapy benefits in lung adenocarcinoma [0.03%]
基于机器学习的肺癌腺癌凝血相关特征及其预后和指导精准治疗价值研究
Xing Cui,Chunxiao Shi
Xing Cui
Background: Venous thromboembolism was a one of frequent complications of lung adenocarcinoma (LUAD) and associated with poor clinical outcome. The interaction of coagulation and tumor immune microenvironment could regula...
Integrated multi-omics analysis identifies DARS2, MRTO4, and MRPL37 as novel biomarkers and potential therapeutic targets for bladder cancer [0.03%]
整合多组学分析鉴定出DARS2、MRTO4和MRPL37是新型尿路上皮癌生物标志物及潜在治疗靶点
Lei Xiao,Yuan Wang,Yujie Xiong et al.
Lei Xiao et al.
Background: Bladder cancer (BC) is the predominant malignant tumor in the urinary system globally, with its intricate molecular features greatly influencing patient outcomes and treatment response.Identifying novel biomar...
Acute Myeloid Leukemia subtype classification using single blood cell images [0.03%]
基于单个血细胞图像的急性髓系白血病亚型分类
Rhea Chainani,Ramitha Vimala,Sakshi Sah et al.
Rhea Chainani et al.
Acute Myeloid Leukemia (AML) is a heterogeneous cancer that affects the myeloid lineage of blood cells. It requires accurate subtype identification for effective treatment. This study proposes a novel framework for AML detection and subtype...
Mitochondrial energy metabolism genes as prognostic biomarkers in clear cell renal cell carcinoma via single-cell and bulk RNA sequencing analyses [0.03%]
单细胞和批量RNA测序分析揭示线粒体能量代谢基因作为透明细胞肾细胞癌预后生物标志物的作用
Yinqi Peng,Dahao Zhang,Shuangyu Wang et al.
Yinqi Peng et al.
The rising incidence of clear cell renal cell carcinoma (ccRCC) with current treatments offering limited survival benefits and a poor prognosis. Mitochondrial abnormalities impact tumor immunity, progression, and metastasis, and the role of...
CXCL10/CXCR3 axis facilitates the M2 polarization of macrophages in colorectal cancer via activating RAF [0.03%]
CXCL10/CXCR3轴通过激活RAF促进结直肠癌中巨噬细胞向M2极化
Xi Sun,Weijian Chu,Yi Wei et al.
Xi Sun et al.
Colorectal cancer (CRC) is a common malignant tumor with high incidence and mortality. Tumor-associated macrophages (TAMs) play a crucial role in CRC progression, with M2 polarization promoting CRC development. The present study explored th...
Investigating the expression of hsa_circ_0036722/hsa-miR-503-5p/PDCD4 axis in esophageal cancer [0.03%]
探究circRNA has_circ_0036722/has-miR-503-5p/PDCD4轴在食管癌中的表达
Shayan Marhamati,Roghayeh Abbasalipourkabir,Zeinab Seyedkhan et al.
Shayan Marhamati et al.
Background: Esophageal cancer (EC) is the ninth most common cancer globally. Circular RNAs (circRNAs), including hsa_circ_0036722, are important in various cancers, but their specific role in EC remains unclear. Therefore...