Durable response to trametinib in a neurofibromatosis type 1 associated adult glioma-a case report [0.03%]
迈替尼治疗神经纤维瘤病Ⅰ型相关成人脑胶质瘤的持久疗效(个案报告)
Santiago Cabezas-Camarero,Rebeca Pérez-Alfayate,Carmen Polidura et al.
Santiago Cabezas-Camarero et al.
Neurofibromatosis type I (NF1) is a heritable disease that may lead to the occurrence of primary central nervous system tumors, including gliomas. Treatment of NF1-associated diffuse gliomas is cumbersome due to the limited evidence and the...
Multi-omics profiling reveals LncRNA ENSG00000253374 as a regulator of GLS-mediated cuproptosis and platinum resistance in ovarian cancer [0.03%]
多组学谱分析揭示长链非编码RNA ENSG00000253374通过GLS介导的铜依赖性细胞死亡调控卵巢癌铂耐药
Rujun Chen,Qiran Sun,Jina Chen et al.
Rujun Chen et al.
Background: Ovarian cancer (OC) has a dismal prognosis due to late diagnosis and platinum resistance, with the molecular mechanisms linking cuproptosis, lncRNAs, and the tumor microenvironment (TME) remaining poorly defin...
Engineering of siRNA molecules to silence SphK1 mRNA for therapeutic intervention in triple-negative breast cancer: An In Silico and In Vitro Analysis [0.03%]
工程化siRNA分子以沉默三阴性乳腺癌治疗干预中的SphK1 mRNA：一种计算和体外分析方法
Siddesh V Siddalingegowda,Bhargav Shreevatsa,Abhigna Nagaraj et al.
Siddesh V Siddalingegowda et al.
Triple-negative breast cancer (TNBC) is an aggressive and therapeutically challenging subtype of breast cancer lacking estrogen, progesterone, and HER2 receptors. Sphingosine kinase 1 (SphK1), a key enzyme in the sphingosine-1-phosphate (S1...
Survival comparison and prognostic nomogram development for stage III rectal cancer with positive tumor deposits using the SEER database [0.03%]
基于SEER数据库的III期直肠癌阳性肿瘤沉积患者的生存对比及预后列线图的建立
Fengjiao Wu,Yuanhui Tian,Qian Han et al.
Fengjiao Wu et al.
Purpose: To compare overall survival (OS) between neoadjuvant chemotherapy (NACT) and adjuvant chemotherapy (ACT) in stage III rectal cancer with tumor deposits (TD), and to develop and validate an ACT-based nomogram for ...
FREM1 promotes anlotinib resistance in non-small cell lung cancer through regulation of extracellular matrix organization [0.03%]
FREM1通过调节细胞外基质组织促进非小细胞肺癌的阿尼鲁单抗耐药性
Yi Dong,Jingjing Zhang,Yuyang Zhao et al.
Yi Dong et al.
Background: Acquired resistance to anlotinib, a multi-targeted tyrosine kinase inhibitor, severely limits its long-term efficacy in non-small cell lung cancer (NSCLC). The extracellular matrix (ECM) is a critical componen...
Pan cancer analyses and clinical cohort validation identify HOMER3 as colorectal cancer prognostic biomarker and therapeutic target [0.03%]
泛癌分析和临床队列验证将HOMER3鉴定为结直肠癌预后生物标志物和治疗靶点
Hong-Chao Zhu,Kun Xia,Wei Wang et al.
Hong-Chao Zhu et al.
Background: HOMER family proteins are extensively expressed across human tissues, exhibiting aberrant expression patterns that are specific to tissues and diseases. HOMER1 has been linked to neurodevelopmental disorders, ...
Pathomic study on the correlation between carbonic anhydrase 9 expression and prognosis in hepatocellular carcinoma [0.03%]
基于碳酸酐酶9表达的肝癌病理影像预后研究
Yuan Liu,Caiwang Gao,Riga Su et al.
Yuan Liu et al.
Background: Glycolytic markers such as carbonic anhydrase 9 (CA9) have been implicated in hepatocellular carcinoma (HCC) prognosis; however, sex-based differences and the underlying pathological mechanisms remain unclear....
Shared genetic liability between opioid analgesic use and lung cancer subtypes revealed by genome wide correlation and structural modeling [0.03%]
基于全基因组关联和结构模型揭示的阿片类镇痛药使用与肺癌亚型之间的共有遗传易感性
Jun Zheng,Chuyan Wang,Jinyu Xu et al.
Jun Zheng et al.
Background: Observational studies link opioid use to lung cancer risk, but findings are inconsistent due to potential confounding and reverse causality. Whether these associations reflect shared genetic liability with his...
COG8 serves as a predictive and prognostic biomarker in lung adenocarcinoma and other human malignancies [0.03%]
COG8可作为肺腺癌及其他人类恶性肿瘤的预测和预后生物标志物
Fei-Xiang Tan,Chun-Yan Zhao,Guo-Sheng Li et al.
Fei-Xiang Tan et al.
Objective: The main objective of this study is to investigate the dysregulated expression, clinical relevance, and underlying mechanisms of COG8 in lung adenocarcinoma (LUAD) and other human malignancies. ...
Precision oncology in cholangiocarcinoma integrates molecular taxonomy testing strategies and treatment sequencing [0.03%]
精确胆管癌肿瘤学整合分子分类检验策略和治疗顺序
Wenzai Shi,Ning Duan,Delin Ma et al.
Wenzai Shi et al.
Cholangiocarcinoma (CCA) is biologically heterogeneous, and timely molecular profiling is increasingly critical for treatment selection in unresectable, recurrent, or metastatic disease. Beyond guideline-style summaries, we provide an imple...