Single-cell profiling identifies a pro-tumoral VCAN positive macrophage subset and defines a prognostic signature in glioblastoma [0.03%]
单细胞分析鉴定出胶质母细胞瘤中促肿瘤的VCAN阳性巨噬细胞亚群并定义其预后标志物
Jiaxin Guo,Zhansheng Zhu,Nanyang Tong et al.
Jiaxin Guo et al.
Glioblastoma (GBM), the most aggressive primary brain tumor, develops within a tumor microenvironment (TME) dominated by tumor-associated macrophages (TAMs) that critically influence disease progression. Through single-cell RNA sequencing (...
Systematic analysis of the mitophagy scoring system in the prognosis and immunotherapy of HCC patients [0.03%]
线粒体自噬评分系统在肝细胞癌患者预后及免疫治疗中的系统分析
Yangjun Yin,Maixuan Qiu,Jun Shen et al.
Yangjun Yin et al.
Background: Mitophagy plays a vital role in hepatocellular carcinoma (HCC) progression. This study aims to construct a mitophagy-related scoring system and evaluate its prognostic value, association with tumor immune acti...
Predictors and kinetics of ATO-induced leukocytosis in acute promyelocytic leukemia patients: a retrospective study [0.03%]
急性早幼粒细胞白血病患者砷剂诱导的白细胞增多的影响因素及动力学特征：一项回顾性研究
Hong Wei,Zhuo Zhang,Xueli Liu et al.
Hong Wei et al.
Background: Although Arsenic trioxide (ATO) has revolutionized acute promyelocytic leukaemia (APL) from a uniformly fatal disease to one of the most curable leukemias, leukocytosis is a common life-threatening side effect...
Leveraging mitochondrial dynamics-related risk signatures to predict the prognosis and tumor microenvironment of lung adenocarcinoma [0.03%]
利用线粒体动态相关风险标志物预测肺腺癌的预后及肿瘤微环境
Li Xu,Danting Zheng,Jisong Zhang et al.
Li Xu et al.
Background: Lung adenocarcinoma (LUAD) is a highly heterogeneous disease, bringing daunting challenges in prognosis prediction. Alterations in mitochondrial dynamics (MD) are crucial in tumor generation and progression. T...
Transcriptional heterogeneity of tumor-associated high endothelial venules defines inflammatory and stress-metabolic states with distinct prognostic associations [0.03%]
肿瘤相关高内皮微静脉的转录异质性定义了具有不同预后关系的炎症和应激代谢状态
Hwal-Seok Choi,Yongjun Lee,Jin-Woo Choi et al.
Hwal-Seok Choi et al.
Tumor-associated high endothelial venules (TA-HEVs) mediate lymphocyte trafficking into tumors and modulate the tumor microenvironment, with reported effects on clinical outcomes. However, reports have described discordant associations acro...
Real-world outcomes of trifluridine/tipiracil with or without bevacizumab in refractory metastatic colorectal cancer: a multicenter cohort study from Turkey [0.03%]
三氟尿苷/-tipiracil单药或联合贝伐珠单抗治疗难治性转移性结直肠癌的现实世界结局：一项来自土耳其多中心队列研究
Selami Bayram,Bahadir Koylu,Maral Martin Mildanoglu et al.
Selami Bayram et al.
Background: Trifluridine/tipiracil (FTD/TPI; TAS-102) is an established later-line treatment option for refractory metastatic colorectal cancer (mCRC), and randomized evidence supports the addition of bevacizumab. However...
The effect of delays in cancer surgery due to the COVID-19 pandemic on cancer resectability and postoperative mortality in different tumor entities [0.03%]
COVID-19大流行导致的癌症手术延迟对不同肿瘤实体的可切除性及术后死亡率的影响
Antonia L Stengler,Jörg Kleeff,Lisa Rieder et al.
Antonia L Stengler et al.
Background: During the COVID-19 pandemic, prioritization of COVID-19 patients led to delays in oncological surgery, potentially impacting patient outcomes. This analysis examines the effects of surgical delays in various ...
Integrated bulk and single-cell transcriptomic analyses identify transcriptome-defined groups and EGFR-associated microenvironmental programs in glioma [0.03%]
整合分析胶质瘤的大规模和单细胞转录组识别转录组图谱及与EGFR相关的微环境程序
Yuanhan Wang,Long Li,Xing Hu et al.
Yuanhan Wang et al.
Background: Glioma exhibits significant molecular heterogeneity, necessitating improved understanding of molecular subtypes for personalized treatment strategies. ...
Integrative analysis of tumor-educated platelets for stage-specific diagnosis, prognosis, and therapy in ovarian cancer [0.03%]
整合分析肿瘤教育血小板用于卵巢癌分期特异性诊断、预后和治疗
Shaimaa Gamal Gahin,Mostafa S Ibrahim,Eman Badr
Shaimaa Gamal Gahin
Background: Ovarian cancer (OC) remains one of the most lethal gynecological cancers worldwide. Despite advances in diagnosis, OC is mostly detected at late stages due to undefined symptoms. Therefore, identifying feasibl...
Hematologic malignancies burden in China compared with the United States 1990-2021 and projections to 2040 [0.03%]
Wenshuai Zheng,Rui Qin,Hang Dong et al.
Wenshuai Zheng et al.
Background: Hematologic malignancies, including leukemia, non-Hodgkin lymphoma (NHL), multiple myeloma (MM), and Hodgkin lymphoma (HL), represent some of the most prevalent cancers. This study aims to comprehensively anal...