Identifying diagnostic markers and constructing a prognostic model for pancreatic cancer based on microarray and bioinformatic analysis [0.03%]
基于微阵列和生物信息学分析的胰腺癌诊断标志物鉴定及预后模型构建
Chang Liu,Dan Qian,Ye Tian et al.
Chang Liu et al.
Background: Pancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide. The lack of effective diagnostic biomarkers and therapeutic targets makes PC difficult to screen and treat. The aim of thi...
Genome-wide investigation of differentially expressed alternative splicing and RNA-binding protein genes association with AML drug resistance [0.03%]
泛基因组差异表达可变剪切和RNA结合蛋白基因与急性髓系白血病药物耐药关联的分析研究
Yu-Mei Zhang,Xue-Yan Dong,Wei Zheng et al.
Yu-Mei Zhang et al.
Background: Acute myeloid leukemia (AML) is a hematologic malignancy with persistently poor outcomes. Despite advances in chemotherapy, targeted therapy, and hematopoietic stem cell transplantation, drug resistance and re...
Primary adenoid cystic carcinoma (basal cell type) of the prostate: a case report [0.03%]
前列腺原发性腺样囊性癌（基底细胞型）一例报告
Ruiqi Xie,Tianshu Chu,Jingshu Cui et al.
Ruiqi Xie et al.
Background: Prostatic adenoid cystic (basal cell) carcinoma is an extremely rare malignant epithelial neoplasm, accounting for a very low proportion of all prostate malignancies. Its clinical symptoms and imaging features...
Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma [0.03%]
整合分析批量和单细胞RNA测序结果揭示了乳头状甲状腺癌中的预后神经模拟标志物
Xinyu Liu,Chengjin Mei,Jifeng Tan et al.
Xinyu Liu et al.
Background: Cancer cells can acquire neuron-like characteristics ("neural mimicry") to promote progression. However, the role of specific ion channel genes in Papillary Thyroid Carcinoma (PTC) and their clinical significa...
Integrated pan-cancer profiling highlights OSR2 as a prognostic indicator and immune-associated biomarker [0.03%]
综合泛癌谱分析突出OSR2作为预后指标和免疫相关生物标志物的作用
Lei Tang,Qiqi Chen,Chunmiao Han et al.
Lei Tang et al.
Background: Odd-skipped-related 2 (OSR2), encoded by the OSR2 gene, has been reported to function as a checkpoint associated with CD8⁺ T-cell exhaustion in the tumor microenvironment of solid malignancies, suggesting its...
Immune subtyping of colorectal adenoma identifies a subtype with activated adaptive immunity ahead of progressing to cancer [0.03%]
结肠腺瘤的免疫分型识别出一个在发展为癌症之前适应性免疫活化的亚型
Ke Chen,Kaiqin Xu,Yu Ding et al.
Ke Chen et al.
Background: Colorectal adenomas (CRA) represent precursor lesions with varying risks of malignant transformation. However, molecular subtyping, particularly immune-related classification, remains underexplored in adenomas...
Toxicity outcomes of concurrent radiotherapy with adjuvant capecitabine in triple-negative breast cancer (TROD 06-24) [0.03%]
三阴性乳腺癌同步放疗序贯卡培他滨辅助治疗毒性反应（TROD 06-24）
Volkan Demircan,Berrin Benli Yavuz,Bekir Hakan Bakkal et al.
Volkan Demircan et al.
Purpose: Triple-negative breast cancer (TNBC), the subtype with the poorest prognosis, shows treatment outcomes closely tied to the response to neoadjuvant chemotherapy. Patients with residual disease post-treatment face ...
A seven-gene diagnostic and prognostic signature for papillary thyroid carcinoma [0.03%]
用于诊断和预测乳头状甲状腺癌的七基因标志物组合检测法
Berna Hukkamlı,Burak Dagdelen,Feyza Sönmez Aydın
Berna Hukkamlı
Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer; however, indeterminate cytology in fine-needle aspiration biopsy (FNAB) and the limited sensitivity of single-mutation-based biomarkers remain important clinica...
Bevacizumab added to conventional induction chemotherapy for children with high risk neuroblastoma (BRAVEN trial) [0.03%]
贝伐单抗联合传统诱导化疗治疗高危神经母细胞瘤患儿（BRAVEN试验）
Jagdish Prasad Meena,Debasish Sahoo,Harshita Makkar et al.
Jagdish Prasad Meena et al.
Background: Despite advances in multimodal therapy, high-risk neuroblastoma (HR-NB) continues to have poor outcomes. Response to induction chemotherapy is a key predictor of long-term survival, yet intensive multi-agent r...
Sex-related differences in pathological characteristics of colorectal cancer: a retrospective study [0.03%]
结直肠癌病理特征性别差异的回顾性研究
Siqi Lan,Zhigang Mao,Deng Tang et al.
Siqi Lan et al.
Purpose: Colorectal cancer (CRC) exhibits substantial sex-related differences in incidence, prognosis, and clinicopathological features. However, existing evidence on these disparities remains limited and inconclusive. Th...