Strategies to reduce intestinal toxicity in neoadjuvant management of locally advanced rectal cancer [0.03%]
局部晚期直肠癌新辅助治疗中减少肠道毒性的策略
Hoda Mahdavi,Sahar Dashti,Shima Jafari
Hoda Mahdavi
The management of locally advanced rectal cancer has progressively evolved to improve both survival outcomes and quality of life. Intestinal toxicity is a prevalent side-effect of pelvic radiotherapy affecting most patients. The pursuit of ...
A prognostic signature based on insulin-signaling-pathway genes for hepatocellular carcinoma [0.03%]
基于胰岛素信号通路基因的肝细胞癌预后特征签名
Yanyan Zhang,Haoqian Song,Wenshuai Cui et al.
Yanyan Zhang et al.
Background: Hepatocellular carcinoma (HCC) is the most common subtype of liver cancer. HCC occurrence, metastasis and therapeutic effect are closely related to tumor metabolic microenvironment. However, the role of insuli...
Identification of an E2Fs-based gene signature for predicting prognosis and therapeutic response in colorectal cancer [0.03%]
一种基于E2Fs的基因特征用于预测结直肠癌预后和治疗反应
Feifan Zhang,Zhiwei Sun,Zhenyu Zhang et al.
Feifan Zhang et al.
E2F family genes are common transcription factors, abnormal in several malignant tumors. However, their complex involvement in colorectal cancer, particularly in prognosis, immune infiltration, and mutational landscape, remains unclear. We ...
Clinicopathological characteristics and molecular genetic analysis of inflammatory and nested testicular sex cord tumor: a case report and literature review [0.03%]
炎性及嵌套睾丸性索间质瘤的临床病理特征和分子遗传分析：1例报告并文献复习
Yan Wang,Yun Xi,Meijuan Wu
Yan Wang
Background: Inflammatory and nested testicular sex cord tumor (IN-SCT) is a newly defined and rare variant of sex cord-stromal tumors, characterized by EWSR1::ATF1 gene fusion, prominent inflammatory infiltration, and agg...
Multi-omics analysis identified LGALS1 (Galectin-1) as a novel therapeutic target for clear cell renal cell carcinoma via targeting epithelial or endothelial cells [0.03%]
多组学分析鉴定出LGALS1（半乳糖凝集素1）是通过靶向上皮细胞或内皮细胞治疗透明细胞肾癌的新的潜在治疗靶点
Xiangyin Tan,Yingfei Chen,Chao Jiang et al.
Xiangyin Tan et al.
Background: Since the pathophysiology of clear cell renal cell carcinoma (ccRCC) was still unknown, finding novel therapeutic targets to support current treatment approaches was crucial. ...
Heparanase2 inhibits the growth of gallbladder cancer by regulating the VEGF/VEGFR pathway [0.03%]
肝素酶2通过调节VEGF/VEGFR信号通路抑制胆囊癌生长
Dengyi Cao,Jiawei Chen,Shaobo Zhou et al.
Dengyi Cao et al.
Heparanase 2 (Hpa2), a homolog of heparinase, lacks the conventional heparinase activity associated with heparin degradation. However, it exhibits a greater affinity for heparin sulfate (HS) compared to heparinase. In our study, overexpress...
Neutrophil extracellular traps (NETs)-score: a novel prognostic marker for colorectal cancer patients [0.03%]
中性粒细胞胞外诱捕网（NETs）评分：一个新的结直肠癌预后标志物
Xiao-Li Wu,Di Hu,Guo-Fa Xu et al.
Xiao-Li Wu et al.
Background: Colorectal cancer (CRC) ranks as the third most prevalent cancer globally, displaying significant tendencies towards recurrence and metastasis. Advanced CRC typically necessitates systemic treatments such as c...
Identification and validation of a prognostic model for HER2-low breast cancer based on unfolded protein response-related genes [0.03%]
基于未折叠蛋白反应相关基因的HER2低表达型乳腺癌预后模型的识别与验证
Yanjiao Zhao,Yuanyuan Gao,Hui Yan et al.
Yanjiao Zhao et al.
Objectives: Human epidermal growth factor receptor 2 (HER2) is down-regulated in approximately 45-55% of breast cancer patients. Cancer cells activate endoplasmic reticulum stress, which is counteracted by the unfolded pr...
Network pharmacology and experimental study on the inhibition of glycolysis by amentoflavone in pancreatic cancer [0.03%]
网络药理学及异鼠李素抑制胰腺癌糖酵解的实验研究
Xu He,Peng Chen,Zhihao Zhao et al.
Xu He et al.
Backgrounds: Pancreatic cancer is one of the most common malignancies in the gastrointestinal system, notorious for its high malignancy and low survival rate. Amentoflavone (AMF), an ingredient in various Traditional Chin...
Single-cell transcriptomic insights into ccRCC: a stemness gene signature for prognosis and treatment response prediction [0.03%]
单细胞测序揭示肾透明细胞癌的干细胞特性基因预后标志及其对治疗反应的预测价值
Jianhui Chen,Xinyi Wu,Guo Han et al.
Jianhui Chen et al.
Clear cell renal cell carcinoma (ccRCC), the most prevalent renal malignancy, exhibits remarkable intratumoral heterogeneity that challenges precise prognostication and treatment stratification. Leveraging single-cell RNA sequencing (scRNA-...