Heparanase2 inhibits the growth of gallbladder cancer by regulating the VEGF/VEGFR pathway
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Heparanase 2 (Hpa2), a homolog of heparinase, lacks the conventional heparinase activity associated with heparin degradation. However, it exhibits a greater affinity for heparin sulfate (HS) compared to heparinase. In our study, overexpression of Hpa2 signific... ...