Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro [0.03%]
体外针对肺癌模型的分化治疗可减少病原特征
Grossi Alice,Fulghieri Paola,Aduvaliev Abdurakhmon et al.
Grossi Alice et al.
Non-small cell lung cancer (NSCLC) relapse after therapy is linked to the high aggressiveness, chemoresistance and metastatic potential of tumor cells due, in part, to the presence of cancer stem cells (CSCs). Pro-differentiation approaches...
Electroacupuncture Improves Cardiac Function in Mice with Myocardial Infarction through Glu Neurons in Ventrolateral Periaqueductal Gray [0.03%]
电针通过脑导水管周围灰质腹外侧神经元改善心肌梗死小鼠心脏功能
Liu Yang,Nan Deng,Fan Zhang et al.
Liu Yang et al.
Ischemic heart disease, a leading global cause of mortality, highlights the need for novel therapies. Electroacupuncture (EA) shows cardioprotective potential, yet the central neural mechanisms, particularly the role of the midbrain periaqu...
What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation? [0.03%]
巨噬细胞招募的T细胞活化中大型:endosomal分选复合体必要的转运的作用是什么？
Anthi Psoma,Femmy C Stempels,Rinse de Boer et al.
Anthi Psoma et al.
Our lab recently discovered uniquely large (multiple micrometres) ring-shaped cellular structures composed of endosomal sorting complexes required for transport (ESCRT) proteins. These structures are formed by tissue infiltrating fibroblast...
Lung Microphysiological System Validates Novel Cell Therapy for Acute Respiratory Distress Syndrome [0.03%]
仿生肺生理系统验证了急性呼吸窘迫综合症的新细胞疗法
Bokyong Kim,So-Hui Kim,Jieun Kim et al.
Bokyong Kim et al.
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and lung damage, leading to critical hypoxemia. Despite its high mortality rate, the only currently available treatment, Dexamet...
RAN Promotes Autophagy and Malignant Progression of Lung Adenocarcinoma through ATG101 [0.03%]
RNА结合蛋白RAN通过ATG101促进肺腺癌自噬及恶性进展
Weiyun Bi,Hongtao Li,Xiaoyong Wu et al.
Weiyun Bi et al.
This study investigates the role and mechanisms of Ras-related nuclear protein (RAN) in lung adenocarcinoma (LUAD). The expression of RAN in LUAD is studied using the The Cancer Genome Atlas (TCGA) database. Clinical samples are collected, ...
FOXP3 Polymorphism and Upregulation of the CXCL12-CXCR4-SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients [0.03%]
FOXP3多态性通过STAT3/NF-κB信号通路上调CXCL12-CXCR4-SNAIL轴和M2型肿瘤相关巨噬细胞浸润影响宫颈癌患者的预后
George A Lira,Fábio M de Azevedo,Ingrid G S Lins et al.
George A Lira et al.
This study explores the interaction between immune and cancer cells in the tumor microenvironment (TME) of cervical carcinoma (CC), with emphasis on tumor-associated macrophages (M2-TAMs) and the STAT3-NF-κB signaling pathway. It investiga...
Qingxin Jianpi Decoction Alleviates Cyclophosphamide-Induced Diminished Ovarian Reserve Via Activation of the PI3K/AKT/Nrf2 Axis and Suppression of Ferroptosis [0.03%]
健脾清欣汤通过激活PI3K/AKT/Nrf2轴并抑制铁死亡来改善环磷酰胺诱导的卵巢功能储备减退
Donglai Hu,Jiayu Shi,Yao Peng et al.
Donglai Hu et al.
Diminished ovarian reserve (DOR), marked by reduced oocyte quantity and quality, remains therapeutically challenging. This study evaluates the protective effects of Qingxin Jianpi Decoction (QXJP) against cyclophosphamide (CTX)-induced DOR ...
Biologics, Biosimilars, and Biobetters: Therapeutic Innovations Reshaping Modern Medicine [0.03%]
生物类似药与生物改良药：现代医学治疗创新药物重塑医疗格局
Joseph Carmelo Kalaw San Pascual,Thaned Kangsamaksin
Joseph Carmelo Kalaw San Pascual
Biologic medicines (or biologics) have revolutionized the treatment of cancer, autoimmune disorders, and genetic conditions. Their therapeutic success stems from complex structural properties that confer high target specificity and biologic...
The Paradox of Heme Oxygenase 1: From Cellular Defense to a Tug of War between Cancer Promotion and Prevention [0.03%]
血红素氧合酶1的悖论：从细胞防御到癌症促发与预防的拉锯战
Sidhant Jain,Meenakshi Rana,Nilza Angmo et al.
Sidhant Jain et al.
The Hmox1 enzyme, which is the inducible enzyme among the Hmoxs, catalyzes the first and rate-limiting step in the heme degradation pathway, generating three byproducts, namely, carbon monoxide, free iron, and biliverdin. These byproducts c...
Osteocytes under Mechanical Loading Regulate PC-3 Cancer Cell-Mineral Interactions during Early-Stage Metastasis to Bone [0.03%]
机械载荷下破骨细胞调控前列腺癌PC-3肿瘤细胞向骨骼早期转移过程中的癌矿物相互作用机制研究
Kimberly Seaman,Bryan Guo,William W Du et al.
Kimberly Seaman et al.
Bone metastasis causes severe complications for patients suffering from advanced-stage prostate cancer. Exercise is recommended to help maintain musculoskeletal health during treatment. As primary mechanosensors and regulators of bone homeo...