Sub-Neuronal Network Profiling of Extracellular Vesicle Release Using a Compartmentalized Neurofluidic Platform [0.03%]
基于隔室化神经微流控平台的细胞外囊泡释放的亚神经元网络分析
Zeynep Malkoc,Esther Stopps,Prince M K Asamoah et al.
Zeynep Malkoc et al.
Extracellular vesicles (EVs) are membrane-bound vesicles that are secreted by a wide range of organisms and cells, carrying cell-specific receptors and molecular cargo such as proteins and nucleic acids. EVs have emerged as promising biomar...
Notoginsenoside R1 as a Protector Against Gentamicin Ototoxicity: Targeting p62-NRF2-GPX4 Ferroptosis Axis [0.03%]
三七皂苷R1通过靶向p62-NRF2-GPX4铁死亡轴对抗庆大霉素耳毒性研究
Xiaorui Chen,Ruoyu Jiang,Yunfeng Chu et al.
Xiaorui Chen et al.
Sudden sensorineural hearing loss (SSNHL) is a common auditory disorder, with oxidative stress and ferroptosis implicated in its pathogenesis. Notoginsenoside R1, a major component of Panax notoginseng, exhibits antioxidant and cytoprotecti...
Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips [0.03%]
个性化生物屏障模型及其疾病模型的研究进展：器官芯片中的最新成果
Franziska Buck,Jeroen Bugter,Gizem Yorukoglu et al.
Franziska Buck et al.
Barrier tissues-epithelial and endothelial interfaces that compartmentalize the human body-govern molecular exchange, immune surveillance, and organ homeostasis. Their dysfunction is central to disorders ranging from dermatitis to neurodege...
Progress in Research on Medication-Related Osteonecrosis of the Jaw: From Pathophysiological Mechanisms to Clinical Treatment [0.03%]
药物相关性颌骨坏死的研究进展：从发病机制到临床治疗
Xinliang Duan,Ziyin Zhang,Sichen Han et al.
Xinliang Duan et al.
Medication-related osteonecrosis of the jaw (MRONJ) is a severe oral disease induced by anti-resorptive and anti-angiogenic drugs. It is characterized by jawbone necrosis, infection, and impaired bone healing, severely affecting the patient...
mmu_circ_0000217 Promotes Osteogenic Differentiation in OCCM-30 Cells via the miR-3064-3p/DKK1 Axis [0.03%]
MMU_CIRC_0000217通过miR-3064-3p/DKK1轴促进OCCM-30细胞成骨分化
Kegang Wang,Cong Zhang,Yu Mai et al.
Kegang Wang et al.
Periodontitis leads to irreversible periodontal tissue damage, and current treatments lack sufficient regenerative capacity. This study investigated the role of mmu_circ_0000217 in osteogenic differentiation of OCCM-30 cementoblastic cells ...
Purva Joshi,Zachary Chau,Abby Callahan-Muller et al.
Purva Joshi et al.
Mosquitoes remain a significant global health concern due to their role in transmitting deadly diseases including malaria, dengue, and yellow fever. Recent advances in genetic modification technologies have enabled researchers to better stu...
PRC2-Related Epigenetic Age Acceleration in Acute Myeloid Leukemia with DNMT3A and IDH2 Mutations [0.03%]
DNMT3A和IDH2基因突变急性髓系白血病的表观遗传学衰老相关机制研究
Zhengyi Yan,Luowei Yuan,Jinxing Wang et al.
Zhengyi Yan et al.
Aging is closely linked to epigenetic remodeling, with DNA methylation (DNAm) emerging as a robust biomarker for estimating epigenetic age (EA) and quantifying senescence. Dysregulation of aging-associated DNAm has been implicated in divers...
Introducing Cellular Senescence in Human Induced Pluripotent Stem Cells and Differentiated Neural Lineage for Modeling of Age-Associated Diseases [0.03%]
人诱导多能干细胞和神经分化谱系中细胞衰老的引入用于建模与年龄相关疾病中的应用
Kashfia Neherin,Kristopher Holloway,Yingduo Song et al.
Kashfia Neherin et al.
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) resets the epigenetic landscapes that mark the aging clock, and consequently cells differentiated from iPSCs resemble fetal cells rather than adult or aged cells. The l...
Dacarbazine as a Positive Control in Melanoma Cell Lines (A375, SK-MEL-103, 1205Lu) and a Human Ex Vivo Skin Model [0.03%]
达卡巴嗪作为黑色素瘤细胞系（A375，SK-MEL-103，1205Lu）和人体外皮肤模型的阳性对照品
Marcel Nani Leite,Natália Aparecida de Paula Rios,Juliana Santos Rosa Viegas et al.
Marcel Nani Leite et al.
One important step for evaluating and selecting a drug is toxicity studies, which are responsible for eliminating molecules that are considered promising for treating a certain disease based on their effectiveness in clinical studies, but a...
Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood [0.03%]
蛋白质组特征随年龄变化从婴儿期到成年晚期都有显著改变
Eveline M Delemarre,Hidde M Smits,Debbie van Baarle et al.
Eveline M Delemarre et al.
Biomarkers are essential in drug development and diagnostics, aiding patient selection and disease monitoring. The lack of age-specific protein references complicates tracking patterns related to chronic disease or treatment. This explorato...