Nghia D Nguyen,Peter G Vekilov
Nghia D Nguyen
Amyloid-β (Aβ) aggregation is targeted with small molecules as a pathway toward developing potential Alzheimer's disease (AD) therapies. Resveratrol, a natural polyphenol, has been proposed as an inhibitor of Aβ aggregation, but its mech...
Dormancy and Recurrence in Breast Cancer Bone Metastasis: From Mechanisms to Clinical Translation [0.03%]
乳腺癌骨转移中的休眠与复发：从机制到临床转化
Ziqi Sun,Baohong Li,Zichao Chen et al.
Ziqi Sun et al.
Breast cancer bone metastasis often involves a prolonged dormancy phase, during which disseminated tumor cells (DTCs) remain undetectable and resistant to conventional therapies, posing a significant risk for late recurrence. Understanding ...
TWIST1 Activates CDCA3 to Promote EMT of Lung Adenocarcinoma and Expression of PD-L1 [0.03%]
TWIST1通过激活CDCA3促进肺腺癌上皮间质转化及PD-L1表达
Jianyi Ding,Junjun Zhao,Jiandong Zhang et al.
Jianyi Ding et al.
CDCA3 and TWIST1 are implicated in cell-cycle control and transcriptional regulation, yet their combined role in lung adenocarcinoma (LUAD) remains unclear. Here, we investigated the impact of the TWIST1/CDCA3 axis on LUAD cell behavior. Le...
Feiwei Mixture Exerts Antitumor Activity Against Non-Small Cell Lung Cancer via Regulating NR1D1-Mediated Immune Cell Infiltration [0.03%]
扶正祛邪方通过调节NR1D1介导的免疫细胞浸润抗非小细胞肺癌作用机制研究
Haiyong Wang,Lingsun Guo,Yu Zhao et al.
Haiyong Wang et al.
Feiwei Mixture (FWHJ), a hospital preparation for lung cancer, lacks a defined mechanism of action. Using Lewis lung carcinoma (LLC) tumor-bearing mice and an LLC-CD8+ T cell co-culture model, we evaluated the effects of FWHJ on tumor growt...
Mechanical Dialogues of Life and Death: How External Molecules Entry Triggers a Chromatin-Cytoskeleton Morphogenetic Duel in Cancer Cells [0.03%]
生命与死亡的机械对话：外来分子进入如何引发癌细胞染色质-细胞骨架形态发生决斗
Parama Dey,Anup Singhania,Ajaikumar B Kunnumakkara et al.
Parama Dey et al.
The next-generation anti-cancer therapeutics must disrupt intracellular mechanics, efficiently eradicating cancer cells, rather than simply intoxicating them. We evaluate the mechanism of action of PCMS, a PAMAM-based supramolecule that era...
Mechanical Cues and Lineage Commitment Govern the Angiogenic Potential of Mesenchymal Cell-Derived Extracellular Vesicles [0.03%]
机械刺激和谱系决定支配间充质细胞源性细胞外囊泡的血管生成潜能
Carolina S Martins,Mimma Maggio,Cansu Gorgun et al.
Carolina S Martins et al.
Bone regeneration requires a finely tuned interplay between osteogenesis and angiogenesis. While current treatments, such as auto/allografts, provide support, they often fail to promote adequate vascularization necessary for complete repair...
Bioelectronic Technology for Nutritional Research-a Novel In Vitro Platform for a Better Understanding of Human Gut Barrier Absorption [0.03%]
营养研究的生物电子技术——一种更好理解人类肠道屏障吸收的新一代体外平台
Verena Stoeger,Magdalena Strauss,Kumar Thurimella et al.
Verena Stoeger et al.
The epithelial gut barrier and gut microbiota significantly contribute to human health by controlling molecule absorption, a regulated transport that dictates bioavailability. Effective public health strategies, like dietary reference value...
The Common Immune Responses Differences from Transcriptomic Profiling in Cardiomyocytes upon Coxsackievirus B5 and Echovirus 6 Infection [0.03%]
基于心肌细胞病毒感染的转录组测序探讨CVB5及E6感染后的心肌免疫反应差异
Yi Xu,Xianwu Lan,Jianwei Chen et al.
Yi Xu et al.
Viral myocarditis (VMC) is a myocardial injury syndrome caused by enterovirus infections, including Coxsackievirus B5 (CVB5) and Echovirus 6 (ECHO6). However, the exact pathogenesis of VMC by enteroviruses remains unclear. Here, the host im...
Emerging Therapeutic Targets and Signaling Networks in Ischemia-Reperfusion Injury [0.03%]
缺血/再灌注损伤中的新兴治疗靶点和信号通路
Shreeya Bhujbal,Lokesh Kumar Bhatt
Shreeya Bhujbal
Ischemia-reperfusion injury remains a major challenge in modern regenerative medicine due to its complex mechanisms, lack of effective therapies, and persistent constrains to translating new interventions from bench to bedside. Currently, t...
Suppression of LncRNA Dlx6os1 Alleviated High Glucose-Induced Oxidative Stress Mediated by Parkin in Cardiomyocytes [0.03%]
LncRNA Dlx6os1的抑制通过Parkin介导缓解心肌细胞高糖诱导的氧化应激
Jiayu Diao,Qiling Gou,Linting Zhang et al.
Jiayu Diao et al.
This study aimed to evaluate the effect of lncDlx6os1 on high glucose (HG)-induced oxidative stress and the involvement of the parkin pathway. Methods: Sh...