Patterning of Multilayer Biointerfaces Driven by Microbubble Lithography Toward Optical Biochips [0.03%]
基于微气泡光刻的多层生物界面图案化朝向光学 biochip
Anand Dev Ranjan,Suyash Narayan Amzare,Subhrokoli Ghosh et al.
Anand Dev Ranjan et al.
The precise and non-invasive integration of biological molecules into engineered surfaces remains a critical challenge in the development of advanced biointerfaces for biophotonics applications. Traditional fabrication techniques often rely...
A Novel Platform for Fast and Cost-Effective Screening of Immunomodulatory Compounds [0.03%]
一种用于快速且经济高效的免疫调节化合物筛选的新平台
Suzana Lj Popovic,Dejan D Baskic,Marina M Mitrovic et al.
Suzana Lj Popovic et al.
Compounds with immunomodulatory properties are increasingly recognized as valuable adjunctive therapies in pathological conditions associated with immune dysregulation. However, their discovery process is often costly and time-consuming. Th...
Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short-Term Spatial Memory via Multiple Ionic and Signaling Mechanisms [0.03%]
GHSR激活通过多种离子和信号机制增强齿状回颗粒细胞兴奋性及短期空间记忆能力
Chidiebele S Oraegbuna,Phani K Kola,Simon L Griggs et al.
Chidiebele S Oraegbuna et al.
Ghrelin is the endogenous ligand of the ghrelin secretagogue receptors (GHSRs). Although the GHSRs are densely expressed in the dentate gyrus (DG) granule cells (GCs), their roles in the DG GCs remain to be fully understood. We probed the a...
Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium [0.03%]
线虫BCAP31或POLR1E的丢失促进衰老并与血管内皮细胞衰老有关
Mengyu Li,Zhenyuan Guo,Yuwei Jiang et al.
Mengyu Li et al.
Aging involves the progressive decline of cellular function, yet the key molecular regulators that determine aging require further identification. Building on our previous finding that the intracellular domain of CD44 (CD44ICD) is a critica...
LncRNA-XIST Competitively Binds to MicroRNA-532-5p to Regulate PTEN Expression, Exacerbating Cerebral Ischemia-Reperfusion Injury [0.03%]
长链非编码RNA-XIST通过竞争性结合微小RNA-532-5p调控PTEN表达从而加重缺血再灌注脑损伤
Xudong Lu,Luhan Chen,Liqi Qian et al.
Xudong Lu et al.
Cerebral ischemia-reperfusion injury (CIRI) is a severe neurological condition. LncRNA-XIST is closely associated with CIRI; however, its underlying mechanism remains unclear. A middle cerebral artery occlusion/reperfusion (MCAO/R) rat mode...
Diagnostic Value of Oxidative Stress-Related Features Mined by WGCNA and Machine Learning in Respiratory Syncytial Virus Infection [0.03%]
基于WGCNA和机器学习挖掘的氧化应激相关特征在呼吸道合胞病毒感染中的诊断价值
Ying Lei,Jiahuan He,Weili Lu et al.
Ying Lei et al.
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in infants and young children, with insufficient early diagnostic biomarkers and unclear molecular mechanisms. Oxidative stress (OS) is centr...
Petra Neumann-Staubitz,Yannick Burgdorf,Sarah Hofmann et al.
Petra Neumann-Staubitz et al.
Sirtuin-1 (Sirt1) is a key NAD+-dependent deacylase regulating metabolism, stress responses, genome stability, and aging. Although well-characterized biochemically and structurally, its substrate selectivity remains unclear: in vitro, Sirt1...
The 20-HETE/GPR75 Axis Drives NLRP1 Inflammasome Activation via p53 in Bronchopulmonary Dysplasia [0.03%]
20-HETE/GPR75轴通过p53激活支气管肺发育不良中的NLRP1炎性小体
QiuXiang Xu,XiaoLi Tian,Bin Li et al.
QiuXiang Xu et al.
Bronchopulmonary dysplasia (BPD), a debilitating chronic respiratory condition afflicting preterm neonates, stems from oxidative injury and is characterized by arrested alveolar growth and aberrant inflammatory responses. This investigation...
Context-Dependent Functional Outcomes of Mitochondrial Transfer: A Donor-Recipient Perspective [0.03%]
基于供体和受体视角的线粒体转移的功能转归取决于情境因素
Bin Wang,Tian Lin,Xinying Mo et al.
Bin Wang et al.
Intercellular mitochondrial transfer has emerged as a fundamental mechanism regulating tissue homeostasis and disease progression, yet its complex regulatory network remains incompletely understood. This review synthesizes the principal tra...
Macroporous Poly-N-Isopropylacrylamide and Cationic Co-Polymer Hydrogels: Long-Term Subcutaneous Implant Biocompatibility [0.03%]
具有大孔结构的聚N-异丙基丙烯酰胺和阳离子共聚物水凝胶的长期皮下植入生物相容性研究
Virginia Capella,Jimena Arri,Ana C Liaudat et al.
Virginia Capella et al.
Biomaterials have been developed with a great potential in tissue engineering. Hydrogels, especially those based on poly-N-isopropylacrylamide (PNIPAM), have innate mechanical and physicochemical similarities with the native extracellular m...