Mir-301b-3p Targets Alx4 to Suppress Cisplatin Sensitivity in Breast Cancer through DNA Damage [0.03%]
Yan Yan,Jianhong Xia,Tingting Ma et al.
Yan Yan et al.
Objective: To elucidate how ALX Homeobox 4 (ALX4) modulates cisplatin sensitivity via DNA damage regulation in breast cancer (BC), this study explored the established role of mRNA-mediated DNA repair in driving chemoresis...
Burden, Trends and Prediction of NAFLD/MAFLD Attributable to Smoking From 1990 to 2021: GBD 2021 Analysis [0.03%]
Lijuan Chen,Ziyi Zhu,Yishu Wang et al.
Lijuan Chen et al.
Smoking is a risk factor for non-alcoholic fatty liver disease (NAFLD, recently proposed as metabolic dysfunction‑associated fatty liver disease, MAFLD), but the global smoking-attributable NAFLD/MAFLD burden remains unclear. Using GBD 202...
iMSCs vs MSCs: Comparative Features and Therapeutic Potential in Wound Healing [0.03%]
比较人诱导间充质干细胞和间充质干细胞在伤口愈合中的特性及治疗潜能
Avinash Sanap,Akshaya Ashok,Kaustubh Raundal et al.
Avinash Sanap et al.
Regenerative medicine is evolving exponentially due to the wide range of therapeutic applications of mesenchymal stromal cells (MSCs), including wound healing. Although the translation of tissue-derived primary MSCs (tMSCs) into clinical pr...
Therapeutic Potential of Stem Cells From Human Exfoliated Deciduous Teeth and Their Derivatives in Immune-Mediated Inflammatory Diseases: Mechanisms and Perspectives [0.03%]
人乳牙干细胞及其衍生细胞在免疫介导的炎症性疾病中的治疗潜力：机制与展望
Wenbo Cui,Dandan Zheng,Anqi Liu et al.
Wenbo Cui et al.
Stem cells from human exfoliated deciduous teeth (SHED) and their derivatives have emerged as promising therapeutic agents for treating immune-mediated inflammatory diseases (IMIDs). IMIDs are characterized by dysregulated immune responses,...
Transcriptional Activation of SBNO2 by KDM1A Drives Immune Escape in Lung Cancer [0.03%]
KDM1A介导SBNO2转录活化促进肺癌免疫逃逸
Deguang Pan,Chong Zhang
Deguang Pan
KDM1A is a crucial epigenetic modulator in tumor immune escape. Nevertheless, its precise regulatory function within the immune microenvironment of lung cancer needs investigation. Using TCGA data, we analyzed KDM1A and SBNO2 expression, cl...
Application and Research Progress of Carbonated Hydroxyapatite in Bone Tissue Regeneration [0.03%]
碳酸羟基磷灰石在骨组织再生中应用及研究进展
Yifu Bian,Xinliang Duan,Sichen Han et al.
Yifu Bian et al.
Carbonated Hydroxyapatite (CHA) has attracted widespread attention in bone tissue regeneration due to its chemical composition and crystal structure, which are similar to natural bone tissue. This review summarizes the basic characteristics...
Tumor-Infiltrating Nociceptor Neurons in Ovarian Cancer Treatment Resistance [0.03%]
卵巢癌治疗抵抗相关的肿瘤浸润痛觉神经元的功能研究
Allison Jorgensen,Daniel W Vermeer,Euihye Jung et al.
Allison Jorgensen et al.
Patients with densely innervated tumors suffer with poor outcomes, thus identifying them could define a cohort that could benefit from aggressive treatments. Most cases and deaths from ovarian cancer are associated with high-grade serous ov...
Nghia D Nguyen,Peter G Vekilov
Nghia D Nguyen
Amyloid-β (Aβ) aggregation is targeted with small molecules as a pathway toward developing potential Alzheimer's disease (AD) therapies. Resveratrol, a natural polyphenol, has been proposed as an inhibitor of Aβ aggregation, but its mech...
Dormancy and Recurrence in Breast Cancer Bone Metastasis: From Mechanisms to Clinical Translation [0.03%]
乳腺癌骨转移中的休眠与复发：从机制到临床转化
Ziqi Sun,Baohong Li,Zichao Chen et al.
Ziqi Sun et al.
Breast cancer bone metastasis often involves a prolonged dormancy phase, during which disseminated tumor cells (DTCs) remain undetectable and resistant to conventional therapies, posing a significant risk for late recurrence. Understanding ...
TWIST1 Activates CDCA3 to Promote EMT of Lung Adenocarcinoma and Expression of PD-L1 [0.03%]
TWIST1通过激活CDCA3促进肺腺癌上皮间质转化及PD-L1表达
Jianyi Ding,Junjun Zhao,Jiandong Zhang et al.
Jianyi Ding et al.
CDCA3 and TWIST1 are implicated in cell-cycle control and transcriptional regulation, yet their combined role in lung adenocarcinoma (LUAD) remains unclear. Here, we investigated the impact of the TWIST1/CDCA3 axis on LUAD cell behavior. Le...