PRC2-Related Epigenetic Age Acceleration in Acute Myeloid Leukemia with DNMT3A and IDH2 Mutations [0.03%]
DNMT3A和IDH2基因突变急性髓系白血病的表观遗传学衰老相关机制研究
Zhengyi Yan,Luowei Yuan,Jinxing Wang et al.
Zhengyi Yan et al.
Aging is closely linked to epigenetic remodeling, with DNA methylation (DNAm) emerging as a robust biomarker for estimating epigenetic age (EA) and quantifying senescence. Dysregulation of aging-associated DNAm has been implicated in divers...
Introducing Cellular Senescence in Human Induced Pluripotent Stem Cells and Differentiated Neural Lineage for Modeling of Age-Associated Diseases [0.03%]
人诱导多能干细胞和神经分化谱系中细胞衰老的引入用于建模与年龄相关疾病中的应用
Kashfia Neherin,Kristopher Holloway,Yingduo Song et al.
Kashfia Neherin et al.
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) resets the epigenetic landscapes that mark the aging clock, and consequently cells differentiated from iPSCs resemble fetal cells rather than adult or aged cells. The l...
Dacarbazine as a Positive Control in Melanoma Cell Lines (A375, SK-MEL-103, 1205Lu) and a Human Ex Vivo Skin Model [0.03%]
达卡巴嗪作为黑色素瘤细胞系（A375，SK-MEL-103，1205Lu）和人体外皮肤模型的阳性对照品
Marcel Nani Leite,Natália Aparecida de Paula Rios,Juliana Santos Rosa Viegas et al.
Marcel Nani Leite et al.
One important step for evaluating and selecting a drug is toxicity studies, which are responsible for eliminating molecules that are considered promising for treating a certain disease based on their effectiveness in clinical studies, but a...
Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood [0.03%]
蛋白质组特征随年龄变化从婴儿期到成年晚期都有显著改变
Eveline M Delemarre,Hidde M Smits,Debbie van Baarle et al.
Eveline M Delemarre et al.
Biomarkers are essential in drug development and diagnostics, aiding patient selection and disease monitoring. The lack of age-specific protein references complicates tracking patterns related to chronic disease or treatment. This explorato...
A tumor Microenvironment-Derived Prognostic Model Guides IL-27 as a Therapeutic Strategy to Restore T Cell Immunity in Lung Adenocarcinoma [0.03%]
基于肿瘤微环境的预后模型指导IL-27作为恢复肺癌腺癌T细胞免疫的治疗策略
Gaopu Xie,Donglin Cai,Gang Zhang et al.
Gaopu Xie et al.
Lung adenocarcinoma (LUAD) exhibits substantial heterogeneity in tumor immune microenvironment (TIME) composition, shaping disease progression and therapeutic response. Here, we integrated transcriptomic and clinical data from TCGA-LUAD to ...
Microfluidic-Based Analysis of Trichomonas Vaginalis Attachment and Drug Response Using AI-Based Imaging Algorithm [0.03%]
基于微流控的AI图像处理算法在阴道毛滴虫黏附及药敏分析中的应用研究
Kin Fong Lei,Boreddy Sai Kiran Reddy,Hong-Wei Luo et al.
Kin Fong Lei et al.
T. vaginalis is a protozoan parasite responsible for the most common non-viral sexually transmitted infection worldwide. Effective therapeutic evaluation is essential, particularly with rising concerns over drug resistance. In this study, w...
Synergistic Roles of FAHD-1 and PYC-1 in Mitochondrial Function, Behavior, and Longevity in C. elegans [0.03%]
FAHD-1和PYC-1在秀丽隐杆线虫线粒体功能、行为及寿命中的协同作用
Riccardo Giaquinta,Andreas Andric,Matthias Scheppach et al.
Riccardo Giaquinta et al.
Mitochondrial metabolism plays a central role in organismal physiology and aging. In Caenorhabditis elegans, FAHD-1 (oxaloacetate decarboxylase) and PYC-1 (pyruvate carboxylase) catalyze opposing reactions that influence oxaloacetate homeos...
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Metabolism and Cell Fate [0.03%]
HK1和HK2：超越糖酵解的线粒体相互作用及其在代谢和细胞命运决定中的双重角色
Noemi Anna Pesce,Giulia Seminara,Giuseppe Giarrusso et al.
Noemi Anna Pesce et al.
HK1 and HK2 are increasingly recognized not only as glycolytic enzymes but also as key modulators of mitochondrial function and cell fate through dynamic interactions with VDAC. This review explores how HK-VDAC complexes support metabolic f...
Functional Integration of Different-Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis [0.03%]
雄性生殖腺移植到成年雌鼠后的功能整合进入下丘脑-垂体-性腺轴
Daniel R Pfau,Monica A Rionda,Evelyn Cho et al.
Daniel R Pfau et al.
Gender-affirming hormone therapy (GAHT) relies on exogenous hormones to produce hormonal milieus that achieve and/or maintain embodiment goals. Another potential route to these endpoints is transplantation of novel steroidogenic tissue. To ...
Recent Advances in Bio-Based Production of Free Heme Using Microbial Metabolic Engineering [0.03%]
基于微生物代谢工程的生物基游离血红素生产研究进展
Wenya Wang,Haitao Geng,Xuting Sun et al.
Wenya Wang et al.
Heme is an iron-containing porphyrin that plays an indispensable role in biological system, involved in oxygen transport, electron transfer, gas sensing, enzyme catalysis, etc. Beyond its physiological functions, heme also has wide-ranging ...