Luisa Klotz,Mike P Wattjes,Tanja Kuhlmann
Luisa Klotz
Multiple sclerosis (MS) is the inflammatory-demyelinating disease of the CNS with the highest prevalence. Despite significant progress in reducing relapse activity by immunomodulatory or immunosuppressive treatments, there are ongoing chall...
Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease [0.03%]
后部皮质萎缩和典型早发性阿尔茨海默病中的神经原纤维缠结分布
Denis S Smirnov,Sophie M Dickinson,Melanie F Estrella et al.
Denis S Smirnov et al.
Background and objectives: Posterior Cortical Atrophy (PCA) is a focal variant of Alzheimer's Disease (AD) characterized by disproportionate and early visuospatial deficits with relative sparing of other cognitive abilities. PCA commonly ar...
Michel Mittelbronn
Michel Mittelbronn
The present collection of studies highlights major conceptual and translational advances in contemporary neurooncology related to the field of neuropathology. Central themes include the increasing recognition of neuron-tumor interactions, i...
Desmoplastic myxoid tumor, SMARCB1-mutant: a case with late recurrence after long-term follow-up [0.03%]
伴有SMARCB1基因突变的粘液样间质肿瘤一例及其长期随访后的复发报告
Arnault Tauziède-Espariat,Mathilde Duchesne,Aymeric Rouchaud et al.
Arnault Tauziède-Espariat et al.
Andrew T McKenzie,Alicia Keberle,Andria Slaughter et al.
Andrew T McKenzie et al.
Expansion microscopy (ExM) physically enlarges biological specimens to enable ultrastructural imaging with conventional fluorescence microscopes. However, its performance in postmortem human brain tissue is unclear. Here, we evaluated how a...
Alzheimer's disease in the Plasticene era: a clinicopathological update on the dual sequestration of amyloid and tau as hijacked innate immune responses [0.03%]
塑料时代的老年痴呆病：淀粉样蛋白和tau蛋白双重隔离的临床病理更新及被劫持的先天免疫反应
Michael A S Guth
Michael A S Guth
Background: The defining neuropathological hallmarks of Alzheimer's disease (AD)-amyloid-β (Aβ) plaques and tau neurofibrillary tangles (NFTs)-are now understood to exist along a continuum with brain aging, yet their fundamental trigger i...
An integrated multiscale imaging workflow to resolve intracellular co-pathology in human FFPE brain tissue [0.03%]
一种整合的多尺度影像工作流程 解析人脑FFPE组织切片中的细胞内共病病理学
Sophie Schreiner,Mónica Miranda de la Maza,Morgane Darricau et al.
Sophie Schreiner et al.
Multiscale and multimodal analysis of post-mortem human brain tissue is essential for improving the characterisation of neurodegenerative diseases (NDDs). Brain bank repositories provide extensive collections of formalin-fixed paraffin-embe...
Unclassifiable senile plaques and extensive cerebral amyloid angiopathy involving spinal and bridging vessels in autopsied patients with Down syndrome [0.03%]
Down综合征患者尸检中未分类老年斑和累及脊髓和桥血管的广泛型脑淀粉样血管病
Hiroaki Miyahara,Yuichi Riku,Kumiko Yano et al.
Hiroaki Miyahara et al.
Background: Individuals with Down syndrome (DS) face markedly increased risk of premature aging and age-related pathological changes, particularly Alzheimer's disease (AD)-like neuropathology. By the fourth decade of life, virtually all ind...
Mads Wolf,Autumn Beck,Laura Paredes et al.
Mads Wolf et al.
Brain banking enables the study of human neural tissue and is essential for research on disease, physiology, and neuroanatomy. An essential step for whole brain studies is the extraction of the brain from the skull. Yet detailed technical d...
Jakob Matschke
Jakob Matschke
This review discusses key publications in forensic neuropathology from the 2025 literature. In abusive head trauma (AHT), biomechanical models help clarify injury mechanisms, particularly the role of sagittal angular acceleration in younger...