Tryptophan Bioconjugation through Auxiliary Boron-Accelerated, Additive-Free Friedel-Crafts Alkylation [0.03%]
通过辅助硼加速的、无需添加剂的friedel-crafts烷基化实现色氨酸生物连接
Chiamaka P Uzoewulu,Emily C Joyner,Jamie C Thuan et al.
Chiamaka P Uzoewulu et al.
Chemical tools have allowed the interrogation of molecular events in biological systems through the realization of additive-free labeling approaches such as strain-promoted chemistry. Although design and synthesis of strained compounds rema...
Organic Heterojunction Nanoparticles: Photoinduced Charge Transfer and Melanin-Amplified ROS Generation for Melanoma Photodynamic Therapy [0.03%]
用于黑色素瘤光动力治疗的有机异质结纳米颗粒：光诱导电荷转移和黑色素增强的ROS生成
Quanyi Jin,Haoyi Wu,Wei Zheng et al.
Quanyi Jin et al.
Melanoma is a life-threatening cancer, requiring more effective treatments. Photodynamic therapy (PDT) is a promising approach with favorable biosafety, although its clinical efficacy remains limited. In this work, we developed a nanoplatfo...
Supramolecular Zwitterionic Polymers: Dynamic Traits Imparted by Ionic Interactions [0.03%]
超分子两性离子聚合物：离子相互作用赋予的动态特性
Jin Wang,Xuedong Xiao,Xinghuo Xiao et al.
Jin Wang et al.
Supramolecular ionic polymers (SIPs) exhibit distinctive dynamic properties, which arise from the synergistic combination of substantial strength and pronounced reversibility of ionic interactions. However, conventional SIPs formed by coass...
Influences of Ring Sizes and Chiral Substituents on Macrocyclic Chelators for Improving 68Ga Radiolabeling [0.03%]
环大小及手性取代基对提高镓放射标记的巨环螯合剂的影响研究
Yifan Zhu,Zhen Cheng,Junhui Zhang et al.
Yifan Zhu et al.
68Ga-labeled macrocyclic ligands have been extensively studied and used for positron emission tomography (PET) imaging. Compared with 12-membered DOTA derivatives, NOTA-based chelators with 9-membered macrocyclic rings exhibit more advantag...
Correction to "DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement" [0.03%]
“DNA 编程的蛋白质降解作用”的勘误：通过 DNA 杂交和链置换动态控制蛋白质降解靶向嵌合体活性
Disha Kashyap,Shozeb Haider,Thomas A Milne et al.
Disha Kashyap et al.
[This corrects the article DOI: 10.1021/jacsau.5c00422.]. © 2026 The Authors. Published by American Chemical Society.
Published Erratum
JACS Au. 2026 Jan 9;6(1):653-655. DOI:10.1021/jacsau.5c01700 2026
Polar-to-Radical Crossover in Catalyst-Free Olefin Halo-Hydroxylamination: A Direct Route to Multifunctional Electrophilic Hydroxylamines [0.03%]
无催化剂烯烃卤羟基胺化中的极性-非极性交叉：多官能团亲电子羟胺的直接合成途径
Young-Do Kwon,Daniel Joaquin,Michael T Davenport et al.
Young-Do Kwon et al.
Herein, we introduce a powerful alkene difunctionalization process where anomeric amides (i.e., N-halogenated-O-activated hydroxylamines) react directly with olefins, without the use of catalysts or additives, to yield the corresponding N-h...
Translating Nature's Design Rules: How Catalysis and Life Science Guide Molecular Catassembly [0.03%]
从自然设计法则到分子催化组装： catalysis和生命科学的指导作用
Hang Qu,Fei Wang,Zhi-Chao Lei et al.
Hang Qu et al.
Molecular assembly is a fundamental organizational principle in both living organisms and the fabrication of functional materials. However, artificial self-assembly systems lag far behind biological systems in terms of efficiency, controlla...
Structure-Based Design of Covalent SARS-CoV‑2 Main Protease Inhibitors Targeting the Nirmatrelvir-Resistant E166 Mutants [0.03%]
基于结构的设计共价SARS-CoV-2主要蛋白酶抑制剂以靶向尼马特韦耐药E166突变体
Zhengjun Cai,Navita Kohaal,Kyriakos Georgiou et al.
Zhengjun Cai et al.
The COVID-19 pandemic spurred the rapid development of nirmatrelvir, a main protease (Mpro) inhibitor now widely prescribed as part of Paxlovid (nirmatrelvir plus ritonavir). However, increasing use has raised concerns about drug resistance...
Fungal-Mineral Interaction: Astrobiology Insights from Iron-Rich Mineral Alteration by an Extremophile Black Fungus [0.03%]
富铁矿物与极端耐受型黑霉菌之间的相互作用：对天体生物学的启示
Alef Dos Santos,Fluvio Molodon,Júnia Schultz et al.
Alef Dos Santos et al.
Iron-rich minerals, such as hematite (α-Fe2O3), are prominent constituents of the Martian surface; they are considered to be potential indicators of past aqueous activity and habitability. This study investigated the interaction between th...
Enzyme-Directed Assembly of Antiparallel Cellulose II Nanocrystals: Unraveling the Mechanism Beyond Spontaneous Crystallization [0.03%]
酶调控抗平行纤维素II纳米晶自组装：自发结晶机理的研究超越
Tomohiro Kuga,Naoki Sunagawa,Kei Kobayashi et al.
Tomohiro Kuga et al.
Humans have long utilized cellulose II, known as regenerated cellulose, for fibers like rayon and Cupra and films like cellophane. While cellulose I, found in nature, consists of parallel molecular chains, cellulose II is characterized by t...