Autonomous Bioluminescence Systems: From Molecular Mechanisms to Emerging Applications [0.03%]
自主生物发光系统：从分子机制到新兴应用
Subhan Hadi Kusuma,Mitsuru Hattori,Takeharu Nagai
Subhan Hadi Kusuma
Autonomous bioluminescence systemsgenetically encoded platforms that integrate luciferase enzymes with complete substrate biosynthetic pathwayshave emerged as transformative tools for real-time, noninvasive imaging in living systems. Un...
Nick-and-Digest Strategy for Programmable Circular ssDNA Production and Scalable DNA Origami Assembly [0.03%]
基于可编程环形单链DNA制备的尼科尔姆消化策略及大规模折纸组装方法
Jingyi Ye,Ao Liu,Hui Lv et al.
Jingyi Ye et al.
DNA origami enables the precise self-assembly of complex nanostructures with applications in drug delivery, biosensing, and nanoelectronics. However, the scalability of DNA origami is constrained by the limited length of the available singl...
Thibaut L M Martinon,Avisikta Sinha,Anthony W Schlimgen et al.
Thibaut L M Martinon et al.
Given the alkalinity of the oceans (pH ≈ 8), carbon dioxide exists in surface oceanwater primarily as bicarbonate (HCO3 -) at relatively high concentrations (2.4 mM) but in the presence of many other anions, some of which are in considerab...
Drastic Impact of Donor Substituents on Xanthenes in the PDT of Glioblastoma [0.03%]
供体取代基对若丹明类化合物光动力治疗胶质母细胞瘤效果的显著影响
O Karaman,E Yesilcimen,M Forough et al.
O Karaman et al.
Even though significant progress has been made in treating various cancer types, brain cancers lag drastically. Several factors contribute, led by operational difficulties, the blood-brain barrier, and the tendency of recurrence. Alternativ...
Single-Stranded RNA Origami Remodels Macrophage to Promote the Synergistic Antitumor Effect with 5‑Fluorouracil in Pancreatic Cancer [0.03%]
单链RNA折纸重编程巨噬细胞促进胰腺癌中与氟尿嘧啶的协同抗肿瘤作用
Xinyi Tu,Lu Yu,Lanshen Zhao et al.
Xinyi Tu et al.
The advancement of cancer immunotherapy has focused on developing therapies that not only target tumor progression but also enhance immune responses, which could potentially shift the balance within the tumor microenvironment (TME) to promo...
Stereogenic and Conformational Diversity in Multicomponent Ir-Catalyzed Borylation of Arenes: Unveiling the Origin of Enantioselectivity by Conformational Sampling [0.03%]
多组分Ir催化芳香烃硼化的手性和构象多样性：通过构象采样揭示对映选择性的起源
Jian-Sen Wang,Xiao-Xia You,Lu Li et al.
Jian-Sen Wang et al.
To date, multicomponent transition-metal-catalyzed asymmetric reactions have led to pivotal breakthroughs in modern catalysis. However, investigations on the mechanism of these reactions are inherent challenges due to the coeffect of the co...
Hydrophilic or Hydrophobic? How Byproducts Change the Water Affinity of Fischer-Tropsch Catalysts [0.03%]
亲水还是疏水？副产品如何改变费托合成催化剂的亲水性
Sanghamitra Sengupta,Alexander J Klaver,Qingyuan Zheng et al.
Sanghamitra Sengupta et al.
The impact of reaction byproducts on the water wettability of Fischer-Tropsch catalysts has been investigated by using supported cobalt and ruthenium catalysts. Water contact angle measurements showed an evolution from 75° to 140° for a s...
A General Approach for Strained Ring Functionalization via Nucleophilic Catalysis [0.03%]
nucleophilic催化的环张力环化实现稠合环化合物的高效合成
Ping Wang,Cheng Deng,Zihao Luo et al.
Ping Wang et al.
Nucleophilic addition to strained rings offers an efficient route to small aliphatic rings, which serve as valuable bioisosteres in drug development. However, these reactions often require external stoichiometric bases, additives, or strong...
Bulky Group Shaping Cyanine as an Efficient Photosensitizer: A Photo-Inducer for Photodynamic Immunotherapy [0.03%]
用于光动力免疫治疗的高效光敏剂：拥挤型氰基茋类染料
He Ma,Zhibin Huang,Chao Shi et al.
He Ma et al.
Photodynamic immunotherapy realized with photosensitizers has garnered significant interest in tumor therapy. A complete set of photosensitizer design rules has not been established yet. Herein, the side arms of thio-pentamethine cyanine dy...
Impact of Tryptophan Positional Isomerism on Physicochemical and Biological Properties: A Case Study Using Gramicidin A Analogs [0.03%]
色氨酸异构化对文拉法辛物理化学和生物性质的影响-来那度胺类似物案例研究
Takahiro Migita,Hiroaki Itoh,Hiroshi Hamamoto et al.
Takahiro Migita et al.
Tryptophan (Trp) displays unique physicochemical properties due to its C3-substituted indole ring, containing a hydrophobic benzene ring and a hydrophilic N-H bond. Herein, we synthetically incorporated five Trp positional isomers with C2/4...