A Hybrid G‑Quadruplex Structure Formed by a Sequence from the MAX Gene [0.03%]
由MAX基因序列形成的混合型G-四链体结构
Xiaodong Hu,Xiao Ni,Wenxian Lan et al.
Xiaodong Hu et al.
Here, we report the NMR solution structure of the G-quadruplex (G4) folded by the 24-nt guanine-rich DNA sequence d-[AG3AG4A2G4TGA2G4A]. The sequence is originated from the first intron of the MAX gene, which encodes the transcription facto...
Phase-Separated Coacervates of Low-Molecular-Weight Compounds for Cytosolic Delivery and Disease Treatment [0.03%]
低分子量化合物相分离共聚物用于细胞质递送和疾病治疗
Yishu Bao,Jiang Xia
Yishu Bao
Liquid-liquid phase separation (LLPS)-driven coacervate droplets, formed by the self-assembly of phase-separating molecules, have emerged as a new platform for the intracellular delivery of macromolecular therapeutics such as antibodies, pl...
Commonality of Mechanism in Glycoside Hydrolases, Nucleoside Hydrolases, and Phosphorylases: Importance of Side-Chain Conformation Preorganization [0.03%]
糖苷酶、核苷酶和磷酸酶机制的共同性：侧链构象预组织的重要性
Po-Sen Tseng,Jonathan C K Quirke,W Jonathan Lin et al.
Po-Sen Tseng et al.
A survey of the Protein Data Bank reveals that the arabinofuranosidase class of enzymes broadly restrict their substrate side chains to the gauche,gauche (gg) conformation that provides maximum electrostatic stabilization to oxocarbenium io...
Unified Asymmetric Synthesis of Aryltetralin Lactone Cyclolignans via Conformation-Assisted Radical C-H Cyclization [0.03%]
基于构象导向自由基C-H环化反应的芳基四氢萘并内酯类环木质素合成统一策略
Rong Yin,Xudong Wang,Rui Zhou et al.
Rong Yin et al.
Aryltetralin lactones featuring vicinal stereogenic centers at their ring junctions are important scaffolds in pharmacologically relevant cyclolignans. Currently, the direct and efficient assembly of tetracyclic core scaffolds from simple a...
Crystallographic, Electronic Structure, and Computational Studies of PHOX-Ni Aryne Complexes: Origins of Regioselectivity in Metal-Bound Aryne Synthesis and Difunctionalization [0.03%]
用于研究PHOX-镍芳炔配合物的晶体学、电子结构及计算研究：金属结合芳炔合成和双官能团化的区域选择性的起源
Alexander Umanzor,Nicholas A Garcia,Kevin P Quirion et al.
Alexander Umanzor et al.
Late transition metal aryne complexes are stable, isolable counterparts to free aryne intermediates. However, their utility has largely been limited since the Aryne Distortion Model (ADM) cannot be applied to substituted aryne complex react...
Total Synthesis and Anomeric Configuration Revision of Zwitterionic Polysaccharide A2's Pentasaccharide Repeating Unit from Bacteroides fragilis [0.03%]
脆弱拟杆菌A2多阴离子多糖五糖重复单元的全合成及其吡喃糖 anomer 配位取向的修正研究
Tianhui Hao,Liangwei Zhang,Tiehai Li
Tianhui Hao
Zwitterionic polysaccharides (ZPSs) represent a distinctive class of bacterial glycans that elicit immune responses via a T-cell-dependent pathway, making them promising immunotherapeutic agents. Herein, we present the first total synthesis...
Xi Xue,Xiangying Liu,Xue Liu et al.
Xi Xue et al.
Targeted covalent drugs have demonstrated remarkable potential in disease treatment over the past decades. However, existing methods for covalent drug design are often limited to serine and cysteine, ignoring other potentially ligandable bi...
Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22 [0.03%]
人类CD22与高亲和力岩藻糖苷化配体结合的分子机制
June Ereño-Orbea,Lijuan Pang,Taylor Sicard et al.
June Ereño-Orbea et al.
CD22 is a sialic acid-binding immunoglobulin-like lectin (Siglec) that maintains a baseline level of B cell inhibition. Its function and restricted expression in B cells make CD22 a validated target in therapies against dysregulated B cells...
Enzymatic Synthesis and Anticoagulant Evaluation of Fucosylated Chondroitin Sulfate Polysaccharides with Defined Sulfation Patterns [0.03%]
定义硫化模式的岩藻糖基硫酸软骨素多糖的酶促合成和抗凝血剂评价
Rongfeng Li,Yuanjie Liu,Kaiqiang Li et al.
Rongfeng Li et al.
Fucosylated chondroitin sulfate (FCS), a uniquely structured glycosaminoglycan with outstanding anticoagulant activity and a lower risk of bleeding, is a promising anticoagulant candidate. However, the complex and heterogeneous structure of...
Shuoshuo Zhang,Zhifang Yang,Haofeng Shi et al.
Shuoshuo Zhang et al.
Iodonium salts have shown great potential as metal-free reagents in various transformations, offering a promising alternative to transition-metal-catalyzed arene amination. Herein, we report the design and synthesis of chromone-based iodoni...