Isopotential Electron Titration of Ammonia Charge Transfer on Metal Catalysts [0.03%]
金属催化剂上氨荷移的等势电子滴定法研究
Jesse R Canavan,Rajat Daga,Ulrick R Gaillard et al.
Jesse R Canavan et al.
Electron transfer between adsorbates and surfaces determines the binding strength and reactivity of chemical moieties on materials designed for separations and catalysis. To quantify electron exchange, the extent of charge transfer resultin...
Microbial Cross-Talk: Unlocking the Cytochalasin Diversity from a Termite-Associated Xylaria [0.03%]
微生物互交：从白蚁相关菌种中解锁细胞松素多样性
Marie Dayras,Yaming Liu,Rebecca Kochems et al.
Marie Dayras et al.
Integrating organismal interaction studies with advanced genomic and metabolomic approaches offer great promise for discovering novel natural products and their derivatives, yet this strategy remains relatively unexplored. Here, we illustra...
High-Pressure Synthesis of the First Thermodynamically Stable Silver Nitride, AgN5 [0.03%]
首个人工合成的热力学稳定的银氮化物AgN5
Akun Liang,Henricus R A Ten Eikelder,Umbertoluca Ranieri et al.
Akun Liang et al.
Being a noble metal, silver is known for its chemical inertness. Molecular nitrogen, due to its extremely strong covalent triple bond, is also typically considered unreactive. It is thus unsurprising that no credible report on the formation...
Mechanism of Singlet Oxygen Generation Catalyzed by CoN4‑Graphene: Insights from Embedded Multi-Configurational Theory [0.03%]
理论研究嵌入多配置理论下CoN4石墨烯正交链催化产生单线态氧的机理
Wei Liu,Xiaolong Liu,Ting Tan
Wei Liu
Efficient generation of singlet oxygen (1O2) underpins critical applications in photodynamic therapy, selective oxidation, and environmental remediation. Single-atom catalysts (SACs), particularly transition-metal-nitrogen-carbon single-ato...
An Integrated Approach Combining Surface Plasmon Resonance Screening with Proteomics Enables Discovery of Natural Molecular Glue Degraders [0.03%]
结合表面等离子体共振筛选与蛋白质组学的整合方法可实现天然分子胶降解剂的发现
Yueying Yang,Rui Zhu,Jing Liang et al.
Yueying Yang et al.
Targeted protein degradation, particularly through molecular glue degraders (MGDs), offers a promising strategy for targeting "undruggable" proteins. However, existing fluorescence-based screening approaches, such as time-resolved fluoresce...
Methanol-Mediated Nickel-Catalyzed Chemo- and Enantioselective Three-Component Alkenylative Coupling of Aldimines and Alkynes with Alkenyl Boronic Acids [0.03%]
甲醇介导的镍催化醛亚胺、炔烃和烯基硼酸的立体和化学选择性三组分加成耦合反应
Zhe-Xuan Li,Si-Chen Tao,Gong-Shun Wang et al.
Zhe-Xuan Li et al.
1,3-Dienyl amines are important and versatile motifs in organic synthesis, and the functionalization of π-components with aldimines has emerged as a powerful strategy for their construction. However, existing methods typically rely on conj...
Gold-Catalyzed Carbonyl Release and its Adaptation for Prodrug Therapy Using Multivalent Lectin-Directed Artificial Metalloenzymes [0.03%]
金催化羰基释放及用于多价 lectin 指导的人工金属酶的前药治疗改造
Jing Huang,Yiling Liu,Yufei Li et al.
Jing Huang et al.
In the framework of developing artificial metalloenzyme (ArM) prodrug therapies, two main factors need to be considered; the cancer targeting capabilities of the ArM biocatalyst and the bioorthogonal prodrug activation mechanism. In this st...
Obtin Alkhamis,Juan Canoura,Gabriel Castro et al.
Obtin Alkhamis et al.
Oligonucleotide-based aptamers are increasingly being used as recognition elements in biosensors to detect analytes relevant to diverse applications including medical diagnostics and therapeutic drug monitoring. Nevertheless, the utility of...
Junhao Guo,Yutong Wang,Guozhu Liu
Junhao Guo
Supercritical fluids (SCFs) play a crucial role in various environmental, geological, and celestial processes primarily due to their unique thermodynamic properties and ability to influence chemical reactions. SCFs are generally thought to ...
Twisted Allenyl-Pyridocyclophanes by Templated Cyclooligomerization: Chiral Cavities for Precision Molecular Recognition [0.03%]
模板环 oligomerization 构建的手性 allenyl-吡啶并 cyclophanes 环：精准分子识别的空腔宿主分子
Jonathan Álvarez-García,María Magdalena Cid
Jonathan Álvarez-García
We report the palladium-catalyzed one-pot synthesis of enantiopure 20-, 30-, and 40-membered cyclophanes shaped by axially twisted allene units. Under Cs+-template, the two smaller macrocycles (2 and 3) are favored over the largest (4). X-r...