Neural circuit mechanisms underlying dominance traits and social competition [0.03%]
神经环路机制下的主导特征和社会竞争
Han Yan,Jin Wang
Han Yan
The survival of animals often hinges on their dominance status, established through repeated social competitions. The dorsomedial prefrontal cortex (dmPFC) plays a pivotal role in regulating these competitions, yet the formation of intrinsi...
The drug resistance feature of acute myeloid leukemia is related to the cell stiffness [0.03%]
急性髓系白血病的药物耐受性与细胞硬度相关性研究
Yu Wang,Hao Jiang,Zhenwei Su et al.
Yu Wang et al.
Acute myeloid leukemia (AML) is a hematologic cancer. Cytarabine-based chemotherapy is the primary treatment. However, drug resistance presents a significant challenge leading to treatment failure. Our study explores the underlying correlat...
Managing surface energy dynamics for enhanced axonal growth: An overview of present and future challenges [0.03%]
调控表面能量动力学促进轴突生长：现状与未来挑战综述
Océane Sénépart,Claire Legay,Ahmed Hamraoui
Océane Sénépart
To create functional neuronal circuit units during nervous system development and/or regeneration, axons are subjected to guidance signals. Expression of these signals occurs in spatiotemporal variations and is translated by the growth cone...
Neus Sanfeliu-Cerdán,Michael Krieg
Neus Sanfeliu-Cerdán
The central goal of mechanobiology is to understand how the mechanical forces and material properties of organelles, cells, and tissues influence biological processes and functions. Since the first description of biomolecular condensates, i...
Sticking together: Polymerization of sickle hemoglobin drives the multiscale pathophysiology of sickle cell disease [0.03%]
粘合在一起：镰状血红蛋白的聚合驱动了镰状细胞病的多尺度病理生理学
Dillon C Williams,Hannah M Szafraniec,David K Wood
Dillon C Williams
Sickle cell disease is a hereditary disorder in which the pathophysiology is driven by the aggregation of a mutant (sickle) hemoglobin (HbS). The self-assembly of deoxygenated sickle hemoglobin molecules into ordered fiber structures has co...
Mesoscopic p53-rich clusters represent a new class of protein condensates [0.03%]
富含p53的介观簇代表了一类新的蛋白质凝聚物
David S Yang,Alexander Tilson,Michael B Sherman et al.
David S Yang et al.
The protein p53 is an important tumor suppressor, which transforms, after mutation, into a potent cancer promotor. Both mutant and wild-type p53 form amyloid fibrils, and fibrillization is considered one of the pathways of the mutants' onco...
Toward universal models for collective interactions in biomolecular condensates [0.03%]
朝着生物分子凝聚体中集体相互作用的通用模型发展
Edoardo Milanetti,Karan K H Manjunatha,GianCarlo Ruocco et al.
Edoardo Milanetti et al.
A wide range of higher-order structures, including dense, liquid-like assemblies, serve as key components of cellular matter. The molecular language of how protein sequences encode the formation and biophysical properties of biomolecular co...
Decoding the effects of mutation on protein interactions using machine learning [0.03%]
利用机器学习解码突变对蛋白质相互作用的影响
Wang Xu,Anbang Li,Yunjie Zhao et al.
Wang Xu et al.
Accurately predicting mutation-caused binding free energy changes (ΔΔGs) on protein interactions is crucial for understanding how genetic variations affect interactions between proteins and other biomolecules, such as proteins, DNA/RNA, a...
Biomembrane structure at the molecular level and its application in precision medicine [0.03%]
生物膜的分子结构及其在精准医疗中的应用
Zicheng Wang,Zhiyuan Tian,Jing Gao et al.
Zicheng Wang et al.
Biomembranes are fundamental to our understanding of the cell, the basic building block of all life. They form important barriers between the cytoplasm and the microenvironment of the cell and separate organelles within cells. Despite subst...
Tinna Pálmadóttir,Josef Getachew,Lei Ortigosa-Pascual et al.
Tinna Pálmadóttir et al.
Amyloids are elongated supramolecular protein self-assemblies. Their formation is a non-covalent assembly process and as such is fully reversible. Amyloid formation is associated with several neurodegenerative diseases, and the reversibilit...