Sticking together: Polymerization of sickle hemoglobin drives the multiscale pathophysiology of sickle cell disease
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Sickle cell disease is a hereditary disorder in which the pathophysiology is driven by the aggregation of a mutant (sickle) hemoglobin (HbS). The self-assembly of deoxygenated sickle hemoglobin molecules into ordered fiber structures has consequences extending... ...
