CRISPR-based Transcriptional Regulation: Technologies, Applications, and Future Directions [0.03%]
基于CRISPR的转录调控：技术、应用及未来方向
Mira A Srinivasa,Mario Escobar
Mira A Srinivasa
CRISPR-based transcriptional regulation technologies, including CRISPR activation (CRISPRa) and CRISPR interference (CRISPRi), offer precise and programmable control over gene expression, representing a major advance in gene and epigenetic ...
Exploring the roles of different DNA Repair Proteins in Short Inverted Repeat Mediated Genomic Instability: A Pilot Study [0.03%]
短倒置重复序列介导的基因组不稳定性的不同DNA修复蛋白的作用：一项初步研究
Pooja Mandke,Karen M Vasquez
Pooja Mandke
Repetitive DNA sequences are abundant in the human genome and can adopt alternative (i.e., non-B) DNA structures. These sequences contribute to diverse biological functions, including genomic instability. Previously, we found that Z-DNA-, H...
Complex Roles of NEIL1 and OGG1: Insights Gained from Murine Knockouts and Human Polymorphic Variants [0.03%]
NEIL1和OGG1的复杂作用：来自小鼠敲除及人类多态性变异的启示
R Stephen Lloyd
R Stephen Lloyd
DNA glycosylases promote genomic stability by initiating base excision repair (BER) in both the nuclear and mitochondrial genomes. Several of these enzymes have overlapping substrate recognition, through which a degree of redundancy in lesi...
Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures [0.03%]
ERCC1-XPF核酸内切酶在处理非B型DNA结构中的多种作用
Tonia T Li,Karen M Vasquez
Tonia T Li
Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., ...
Synthesis of sensitive oligodeoxynucleotides containing acylated cytosine, adenine, and guanine nucleobases [0.03%]
含酰化胞嘧啶、腺嘌呤和鸟嘌呤核苷碱基的高灵敏寡脱氧核糖核酸的合成
Komal Chillar,Rohith Awasthy,Marina Tanasova et al.
Komal Chillar et al.
The synthesis of oligodeoxynucleotides (ODNs) containing the base-labile N 6-acetyladenosine (6acA), N 2-acetylguanosine (2acG), and N4-methyoxycarbonyldeoxycytidine (4mcC), as well as up to four N 4-acetyldeoxycytidine (4acC) modifications...
DNA as a Double-Coding Device for Information Conversion and Organization of a Self-Referential Unity [0.03%]
作为信息转换和组织自参照统一性的双编码装置的DNA
Georgi Muskhelishvili,William Nasser,Sylvie Reverchon et al.
Georgi Muskhelishvili et al.
Living systems are capable on the one hand of eliciting a coordinated response to changing environments (also known as adaptation), and on the other hand, they are capable of reproducing themselves. Notably, adaptation to environmental chan...
Elizabeth Walsh,Tran Zen B Torres,Brian C Prince et al.
Elizabeth Walsh et al.
Background/objectives: Culex species mosquitoes are globally distributed and transmit several pathogens that impact animal and public health, including West Nile virus, Usutu virus, and Plasmodium relictum. Despite their ...
How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans [0.03%]
染色质马达复合物如何影响核结构——线虫中染色质组织、粘连蛋白和致密化蛋白的研究综述
Bahaar Chawla,Gyӧrgyi Csankovszki
Bahaar Chawla
Chromatin is the complex of DNA and associated proteins found in the nuclei of living organisms. How it is organized is a major research field as it has implications for replication, repair, and gene expression. This review summarizes the c...
Eshna Jash,Györgyi Csankovszki
Eshna Jash
Embryogenesis is characterized by dynamic chromatin remodeling and broad changes in chromosome architecture. These changes in chromatin organization are accompanied by transcriptional changes, which are crucial for the proper development of...
8-OxodG: A Potential Biomarker for Chronic Oxidative Stress Induced by High-LET Radiation [0.03%]
8-羟基脱氧鸟苷：高 LET 辐射所致慢性氧化应激的潜在生物标志物
Kamendra Kumar,Albert J Fornace Jr,Shubhankar Suman
Kamendra Kumar
Oxidative stress-mediated biomolecular damage is a characteristic feature of ionizing radiation (IR) injury, leading to genomic instability and chronic health implications. Specifically, a dose- and linear energy transfer (LET)-dependent pe...