Rebuilding the Marrow In Vitro: Translational Advances in the 3D Modeling of Blood Cancers [0.03%]
离体重塑骨髓：血液肿瘤三维模型的转化研究进展
Giovannino Silvestri,Aditi Chatterjee
Giovannino Silvestri
Hematological malignancies such as acute myeloid leukemia (AML), chronic myeloid leukemia (CML), lymphomas, and multiple myeloma remain difficult to model ex vivo because conventional two-dimensional (2D) cultures and murine systems fail to...
Yi-Ling Chen,Nicholas Pascuzzi,Alejandro Ruiz et al.
Yi-Ling Chen et al.
Mirtrons represent a new subclass of microRNAs (miRNAs) that are processed through non-canonical biogenesis pathways. Unlike canonical miRNAs, which require Drosha-mediated cleavage, mirtrons are generated via the splicing of short intronic...
Exploring the Potential of Epiregulin and Amphiregulin as Prognostic, Predictive, and Therapeutic Targets in Colorectal Cancer [0.03%]
人表皮生长因子配体Epgn和Areg在结直肠癌中的预后、预测及治疗靶点潜能研究
Cara Guernsey-Biddle,Peyton High,Kendra S Carmon
Cara Guernsey-Biddle
The epidermal growth factor receptor (EGFR) plays a critical role in regulating essential cellular processes that are frequently hijacked to promote cancer. In colorectal cancer (CRC) in particular, the EGFR signaling pathway is frequently ...
Transcriptome Analysis Identifies Tumor Immune Microenvironment Signaling Networks Supporting Metastatic Castration-Resistant Prostate Cancer [0.03%]
转录组分析识别出支持转移性去势抵抗性前列腺癌的肿瘤免疫微环境信号网络
Lawrence P McKinney,Rajesh Singh,I King Jordan et al.
Lawrence P McKinney et al.
Prostate cancer (PCa) is the second most common cause of cancer death in American men. Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal form of PCa and preferentially metastasizes to the bones through incompletely ...
Whole Genome Variant Dataset for Enriching Studies across 18 Different Cancers [0.03%]
用于丰富18种不同类型癌症研究的全基因组变异数据集
John Torcivia,Kawther Abdilleh,Fabian Seidl et al.
John Torcivia et al.
Whole genome sequencing (WGS) has helped to revolutionize biology, but the computational challenge remains for extracting valuable inferences from this information. Here, we present the cancer-associated variants from the Cancer Genome Atla...
Chenlu Ke,Dipankar Bandyopadhyay,Mario Acunzo et al.
Chenlu Ke et al.
Background: Advances in sequencing technologies have allowed collection of massive genome-wide information that substantially advances lung cancer diagnosis and prognosis. Identifying influential markers for clinical endp...
ERBB1/EGFR and JAK3 Tyrosine Kinases as Potential Therapeutic Targets in High-Risk Multiple Myeloma [0.03%]
ERBB1/EGFR和JAK3酪氨酸激酶可作为高危多发性骨髓瘤的潜在治疗靶点
Fatih M Uckun,Sanjive Qazi
Fatih M Uckun
Our main objective was to identify abundantly expressed tyrosine kinases in multiple myeloma (MM) as potential therapeutic targets. We first compared the transcriptomes of malignant plasma cells from newly diagnosed MM patients who were ris...