Obesity Is Associated with Increased F2-Isoprostanes and IL-6 in Black Women [0.03%]
肥胖的黑人女性F2异前列醇和IL-6升高
Mohammad Saleem,Paul D Kastner,Pouya Mehr et al.
Mohammad Saleem et al.
Obesity affects over 40% of the adult population and is a major risk factor for morbidity and mortality due to cardiovascular disease. Black women have one of the highest prevalences of obesity, insulin resistance, hypertension, and cardiov...
CRABP1 Signalosomes in Non-Canonical Actions of Retinoic Acid-Maintaining Health and Preventing Thyroid Dysfunction in Aging [0.03%]
crabp1 衍生信号在非经典视黄酸作用中的维持健康和预防衰老所致甲状腺功能障碍方面的作用
Jennifer Nhieu,Fatimah Najjar,Li-Na Wei
Jennifer Nhieu
Retinoic acid (RA) exerts biological effects through RA receptors (RARs) to regulate transcription. RA also elicits rapid, RAR-independent (noncanonical) activities mediated by Cellular RA Binding Protein 1 (CRABP1) to modulate cytosolic si...
Serum IL-1ra Is Associated with but Has No Genetic Link to Type 1 Diabetes [0.03%]
IL-1ra与遗传无关但与1型糖尿病相关
Paul M H Tran,Fran Dong,Khaled Bin Satter et al.
Paul M H Tran et al.
Interleukin-1 antagonism is a proposed biomarker and potential therapy for the delay and/or treatment of type 1 diabetes (T1D). We evaluated the role of circulating interleukin-1 receptor antagonist (IL-1ra) in a prospectively monitored coh...
Unraveling the Genetic Link Between Endocrine Hormones and Psychiatric Disorders: An Atlas of Genetic Correlations [0.03%]
解密内分泌激素与精神病障碍之间的遗传联系：一份遗传相关性图谱
James L Li
James L Li
Background/objectives: Endocrine hormones play critical roles in regulating physiological processes, and previous studies have reported their associations with psychiatric disorders. Levels of endocrine hormones and the r...
Effects of the Menstrual Cycle Phase on Cortisol Responses to Maximum Exercise in Women With and Without Premenstrual Syndrome [0.03%]
月经周期相位对女性（经前综合征患者和非经前综合征患者）最大运动时皮质醇反应的影响
Raul Cosme Ramos Prado,Tamires Nunes Oliveira,Bryan Saunders et al.
Raul Cosme Ramos Prado et al.
Objectives: This study investigated the effects of the menstrual cycle phases on cortisol levels before and after a maximal incremental exercise test in women with and without premenstrual syndrome (PMS). ...
Anthony C Hackney,Raul Cosme Ramos Prado,Eimear Dolan
Anthony C Hackney
This study investigated the impact of intensive endurance exercise on circulating androgenic steroid hormones in women. Fifteen normally menstruating athletic women participated. They completed intensive endurance exercise (treadmill runnin...
Protective Activities of Growth Hormone-Releasing Hormone Antagonists against Toxin-Induced Endothelial Injury [0.03%]
生长激素释放肽受体拮抗剂对内皮细胞的保护作用及其机制研究
Saikat Fakir,Nektarios Barabutis
Saikat Fakir
GHRH regulates the secretion of GH from the anterior pituitary gland, previously associated with cancer progression and inflammation. An emerging body of evidence suggests that GHRHAnt support endothelial barrier function, but the mechanism...
Biomarkers of Neurodegeneration and Alzheimer's Disease Neuropathology in Adolescents and Young Adults with Youth-Onset Type 1 or Type 2 Diabetes: A Proof-of-Concept Study [0.03%]
青少年期或青年期发病的1型或2型糖尿病患者神经退行性病变和阿尔茨海默病神经病理生物标志物的概念验证研究
Allison L B Shapiro,Christina Coughlan,Brianne M Bettcher et al.
Allison L B Shapiro et al.
Adult-onset diabetes increases one's risk of neurodegenerative disease including Alzheimer's disease (AD); however, the risk associated with youth-onset diabetes (Y-DM) remains underexplored. We quantified plasma biomarkers of neurodegenera...
Perceptions of Youth and Parent Decision-Making Roles Regarding Recombinant Human Growth Hormone Treatment [0.03%]
关于重组人生长激素治疗的青年及父母决策角色的认知
Ettya R Fremont,Elizabeth A Friedrich,Chris Feudtner et al.
Ettya R Fremont et al.
Recombinant human growth hormone (rhGH) is prescribed to youth with growth hormone deficiency (GHD) to support normal growth and ensure healthy physical development, and to youth without GHD to address height concerns. Perceptions of youth ...
Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells [0.03%]
生长激素释放激素拮抗剂JV-1-36抑制A549肺癌细胞中的活性氧的产生
Khadeja-Tul Kubra,Mohammad S Akhter,Kaitlyn Apperley et al.
Khadeja-Tul Kubra et al.
Growth hormone-releasing hormone (GHRH) and its receptors are expressed in a variety of human cancers, and have been involved in malignancies. GHRH antagonists (GHRHAnt) were developed to suppress tumor progression and metastasis. Previous ...