Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder [0.03%]
用电刺激治疗强迫症时反映靶点作用和疗效的电生理生物标志物的研究
Tine Van Bogaert,Martijn Figee,Brian H Kopell et al.
Tine Van Bogaert et al.
Background: Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) is an effective treatment for severe, treatment-resistant obsessive-compulsive disorder (OCD). However, optimizing lead placemen...
Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients [0.03%]
基于医院675680名患者样本的功能性癫痫发作障碍的多中心、多祖先的全基因组关联研究元分析
Slavina B Goleva,Costin Leu,Yen-Chen Anne Feng et al.
Slavina B Goleva et al.
Background: Functional seizures (FS) are paroxysmal episodes that phenotypically resemble epileptic seizures but are not associated with brain epileptiform discharges; they are also known as psychogenic nonepileptic seizu...
Florian Freudenberg
Florian Freudenberg
Adolescent Risky Alcohol Use Is Associated With Electrophysiological Markers of Error Processing: Findings From a Large Cohort Study [0.03%]
一项大型队列研究的结果：青少年冒险性酒精使用与错误处理的电生理标志有关
Olga D Boer,Hanan El Marroun,Doga Ultanir et al.
Olga D Boer et al.
Background: Altered electrophysiological error processing, measured via the error-related negativity (ERN), error-related positivity (Pe), and midfrontal theta power (FM-theta), has been associated with problematic alcoho...
Cortical GABAergic Neuron Dysregulation in Schizophrenia Is Age Dependent [0.03%]
年龄依赖性额叶皮层GABA能神经元紊乱与精神分裂症之间的关系
Daniel Kiss,Xiaolin Zhou,Nicole Endresz et al.
Daniel Kiss et al.
Background: Cortical GABAergic (gamma-aminobutyric acidergic) neuron dysregulation is implicated in schizophrenia (SCZ), but it remains unclear whether these changes are due to altered cell proportions or per-cell changes...
Anni L K Malmberg,Matti Pirinen,Johannes Kettunen et al.
Anni L K Malmberg et al.
Background: Episodic memory (EM) refers to the ability to encode and recall events-a vital cognitive function for healthy cognitive aging and an endophenotype for dementia. ...
Luis C Farhat,Kayoko Isomura,Ralf Kuja-Halkola et al.
Luis C Farhat et al.
Background: Trichotillomania is an understudied psychiatric disorder characterized by repeated hair-pulling resulting in hair loss. Little is known about the risk of problematic substance use in this patient group. In thi...
Bipolar Disorder VII: Family History and Its Relationship With Suicide Attempts, Severity, and the Prophylactic Effect of Lithium Treatment in a Long-Term Follow-Up Study of Bipolar Disorder [0.03%]
双相障碍第七部分：家族史及其与企图自杀、严重程度和长期随访研究中锂治疗预防作用的关系
Per-Olof Nylander,Erik Lexne,Christer Lehman et al.
Per-Olof Nylander et al.
Background: Family history (FH) of affective disorders (ADs) is important for the course of bipolar disorder (BD). Methods: In a long-t...
Therapeutic Shifts and Scientific Influence in Treatment-Resistant Depression Research: A Data-Driven Perspective [0.03%]
治疗抵抗型抑郁研究中的治疗转变和科学影响力：数据驱动视角
Yunsheng Liu,Zengwei Kou
Yunsheng Liu
Background: Treatment-resistant depression (TRD) remains a major psychiatric challenge, with therapeutic paradigms evolving over the last 50 years. However, research on TRD is fragmented across molecular mechanisms, clini...
Role of the Locus Coeruleus in Response to Threat in Anxiety Disorders and Posttraumatic Stress Disorder: An Ultra-High-Field 7T Functional Magnetic Resonance Imaging Study [0.03%]
蓝斑在焦虑症和创伤后应激障碍威胁反应中的作用：一项超高磁场（7T）功能性磁共振成像研究
Sarah C Boukezzi,Philipp T Neukam,Nicholas Balderston et al.
Sarah C Boukezzi et al.
Background: By harnessing the enhanced spatial resolution and signal power of high-field 7T magnetic resonance imaging (MRI), we assessed the functional involvement of the locus coeruleus (LC), together with the broader t...