Helping proteins come in from the cold: 5 burning questions about cold-active enzymes [0.03%]
助蛋白质走出寒冷：关于冷活性酶的五大热点问题
Jan Stanislaw Nowak,Daniel E Otzen
Jan Stanislaw Nowak
Enzymes from psychrophilic (cold-loving) organisms have attracted considerable interest over the past decades for their potential in various low-temperature industrial processes. However, we still lack large-scale commercialization of their...
Kevin Chen,Yaya Guo,Kenneth How et al.
Kevin Chen et al.
Global warming is caused by human activity, such as the burning of fossil fuels, which produces high levels of greenhouse gasses. As a consequence, climate change impacts all organisms and the greater ecosystem through changing conditions f...
Fibril core regions in engineered α-synuclein dimer are crucial for blocking of fibril elongation [0.03%]
工程化α-突触核蛋白二聚体中纤维核心区域对于抑制纤维延伸至关重要
Celina M Schulz,Anne Pfitzer,Wolfgang Hoyer
Celina M Schulz
Synucleinopathies like Parkinson's disease are neurodegenerative diseases which are associated with the deposition of fibrillar aggregates of the endogenous protein α-synuclein (α-syn). The inhibition of the elongation of α-syn fibrils i...
Investigating the biochemical signatures and physiological roles of the FMO family using molecular phylogeny [0.03%]
基于分子谱系的FMO家族生化标志物及其生理功能的研究
C R Nicoll,M L Mascotti
C R Nicoll
Group B flavin-dependent monooxygenases are employed in swathes of different physiological functions. Despite their collectively large substrate profile, they all harness a flavin-based C4a-(hydro)peroxy intermediate for function. Within th...
C-value paradox: Genesis in misconception that natural selection follows anthropocentric parameters of 'economy' and 'optimum' [0.03%]
C值悖论：基于“经济性”和“最适性”的自然选择的人类中心观的误解所致
Subhash C Lakhotia
Subhash C Lakhotia
C-value paradox refers to the lack of correlation between biological complexity and the intuitively expected protein-coding genomic information or DNA content. Here I discuss five questions about this paradox: i) Do biologically complex org...
Cristina R Ventura,Gregory R Wiedman
Cristina R Ventura
Antimicrobial peptide buforin II translocates across the cell membrane and binds to DNA. Its sequence is identical to a portion of core histone protein H2A making it a highly charged peptide. Buforin II has a proline residue in the middle o...
Loss of INPP5K attenuates IP3-induced Ca2+ responses in the glioblastoma cell line U-251 MG cells [0.03%]
INPP5K缺失减弱胶质母细胞瘤U-251MG细胞中IP3引起的Ca2+反应
Jens Loncke,Tomas Luyten,Ana Raquel Ramos et al.
Jens Loncke et al.
INPP5K (inositol polyphosphate 5-phosphatase K) is an endoplasmic reticulum (ER)-resident enzyme that acts as a phosphoinositide (PI) 5-phosphatase, capable of dephosphorylating various PIs including PI 4,5-bisphosphate (PI(4,5)P2), a key p...
Myeloid-derived suppressor cells promote the formation of abdominal aortic aneurysms through the IL-3-ICOSL-ICOS axis [0.03%]
髓系抑制细胞通过IL-3-ICOSL-ICOS轴促进腹主动脉瘤的形成
Li Lu,Yi Jin,Yuanhao Tong et al.
Li Lu et al.
Th17 cells are powerful inflammation promoters in the pathogenesis of abdominal aortic aneurysms (AAAs). Myeloid-derived suppressor cells (MDSCs) can promote the differentiation of Th17 cells in chronic inflammatory autoimmune injury. Here,...
Natamycin interferes with ergosterol-dependent lipid phases in model membranes [0.03%]
那他霉素干扰模型膜中的麦角固醇依赖性脂质相态
Vibeke Akkerman,Holger A Scheidt,Peter Reinholdt et al.
Vibeke Akkerman et al.
Natamycin is an antifungal polyene macrolide that is used as a food preservative but also to treat fungal keratitis and other yeast infections. In contrast to other polyene antimycotics, natamycin does not form ion pores in the plasma membr...
Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail [0.03%]
基于分子动力学的药物膜通透性原子级研究进展
André M M Gomes,Paulo J Costa,Miguel Machuqueiro
André M M Gomes
Several factors affect the passive membrane permeation of small molecules, including size, charge, pH, or the presence of specific chemical groups. Understanding these features is paramount to identifying or designing drug candidates with o...