Water content, transition temperature and fragility influence protection and anhydrobiotic capacity [0.03%]
水分含量，转变温度和脆性影响保护和无水生物能力
John F Ramirez,U G V S S Kumara,Navamoney Arulsamy et al.
John F Ramirez et al.
Water is essential for metabolism and all life processes. Despite this, many organisms distributed across the kingdoms of life survive near-complete desiccation or anhydrobiosis. Increased intracellular viscosity, leading to the formation o...
Thomas Bick,Paulina M Dominiak,Petra Wendler
Thomas Bick
The Coulomb potential maps generated by electron microscopy (EM) experiments contain not only information about the position but also about the charge state of the atom. This feature of EM maps allows the identification of specific ions and...
Spectroelectrochemistry for determination of the redox potential in heme enzymes: Dye-decolorizing peroxidases [0.03%]
用于测定血红素酶中的氧化还原电位的光谱电化学研究：染料脱色过氧化物酶
Catarina Barbosa,Carolina F Rodrigues,Nikola Lončar et al.
Catarina Barbosa et al.
Dye-decolorizing peroxidases (DyPs) are heme-containing enzymes that are structurally unrelated to other peroxidases. Some DyPs show high potential for applications in biotechnology, which critically depends on the stability and redox poten...
Helping proteins come in from the cold: 5 burning questions about cold-active enzymes [0.03%]
助蛋白质走出寒冷：关于冷活性酶的五大热点问题
Jan Stanislaw Nowak,Daniel E Otzen
Jan Stanislaw Nowak
Enzymes from psychrophilic (cold-loving) organisms have attracted considerable interest over the past decades for their potential in various low-temperature industrial processes. However, we still lack large-scale commercialization of their...
Kevin Chen,Yaya Guo,Kenneth How et al.
Kevin Chen et al.
Global warming is caused by human activity, such as the burning of fossil fuels, which produces high levels of greenhouse gasses. As a consequence, climate change impacts all organisms and the greater ecosystem through changing conditions f...
Fibril core regions in engineered α-synuclein dimer are crucial for blocking of fibril elongation [0.03%]
工程化α-突触核蛋白二聚体中纤维核心区域对于抑制纤维延伸至关重要
Celina M Schulz,Anne Pfitzer,Wolfgang Hoyer
Celina M Schulz
Synucleinopathies like Parkinson's disease are neurodegenerative diseases which are associated with the deposition of fibrillar aggregates of the endogenous protein α-synuclein (α-syn). The inhibition of the elongation of α-syn fibrils i...
Investigating the biochemical signatures and physiological roles of the FMO family using molecular phylogeny [0.03%]
基于分子谱系的FMO家族生化标志物及其生理功能的研究
C R Nicoll,M L Mascotti
C R Nicoll
Group B flavin-dependent monooxygenases are employed in swathes of different physiological functions. Despite their collectively large substrate profile, they all harness a flavin-based C4a-(hydro)peroxy intermediate for function. Within th...
C-value paradox: Genesis in misconception that natural selection follows anthropocentric parameters of 'economy' and 'optimum' [0.03%]
C值悖论：基于“经济性”和“最适性”的自然选择的人类中心观的误解所致
Subhash C Lakhotia
Subhash C Lakhotia
C-value paradox refers to the lack of correlation between biological complexity and the intuitively expected protein-coding genomic information or DNA content. Here I discuss five questions about this paradox: i) Do biologically complex org...
Cristina R Ventura,Gregory R Wiedman
Cristina R Ventura
Antimicrobial peptide buforin II translocates across the cell membrane and binds to DNA. Its sequence is identical to a portion of core histone protein H2A making it a highly charged peptide. Buforin II has a proline residue in the middle o...
Loss of INPP5K attenuates IP3-induced Ca2+ responses in the glioblastoma cell line U-251 MG cells [0.03%]
INPP5K缺失减弱胶质母细胞瘤U-251MG细胞中IP3引起的Ca2+反应
Jens Loncke,Tomas Luyten,Ana Raquel Ramos et al.
Jens Loncke et al.
INPP5K (inositol polyphosphate 5-phosphatase K) is an endoplasmic reticulum (ER)-resident enzyme that acts as a phosphoinositide (PI) 5-phosphatase, capable of dephosphorylating various PIs including PI 4,5-bisphosphate (PI(4,5)P2), a key p...