Role of recombinant S100A13 expression in regulating mitochondrial fission and fusion in lung epithelial cells [0.03%]
重组S100A13在调节肺上皮细胞线粒体分裂和融合中的作用
Somaya Alqattan,Mona Alonazi,Eid Almutairy et al.
Somaya Alqattan et al.
S100A13, a calcium-binding protein containing two EF-hand motifs, contributes to intracellular calcium homeostasis, a key determinant of mitochondrial quality control. We previously showed that S100A13 modulates mitochondrial membrane poten...
Lysosomal membrane permeabilization is involved in CYP2E1-induced apoptosis in hepatocellular carcinoma cells [0.03%]
CYP2E1诱导的肝癌细胞凋亡与溶酶体膜损伤有关
Xuan Wang,An Wang,Huanhuan He et al.
Xuan Wang et al.
CYP2E1 expression is often negatively correlated with hepatocellular carcinoma (HCC) progression, and its overexpression induces apoptosis in HCC cells. However, the underlying mechanism of CYP2E1 in apoptosis induction remains unclear. Giv...
miR-765 induces angiogenesis by inhibiting dipeptidyl peptidase 4 and increasing fibroblast growth factor 2 [0.03%]
微RNA-765通过抑制二肽基肽酶4诱导血管生成并增加成纤维细胞生长因子2
Koji Ueno,Hiroshi Kurazumi,Junichi Murakami et al.
Koji Ueno et al.
Given that extracellular vesicles (EVs) secreted from stem cells contain angiogenic microRNAs (miRNAs), these EVs show equivalent angiogenic therapeutic effect to cell transplantation. This study aimed to identify the angiogenic miRNAs from...
Drying parameters and aging modulate protective properties of vitrified trehalose [0.03%]
干燥参数和老化调节了玻璃态海藻糖的保护作用属性
U G V S S Kumara,Thomas C Boothby
U G V S S Kumara
Storage of biological materials underpins medical, research, and biotechnological applications. Although cold-chain preservation is effective, it is costly, infrastructure-dependent, and vulnerable to disruption. Room-temperature dry storag...
AGTRAP mediates exosome-driven communication between cancer cells and macrophages via p38 MAPK pathway to promote hepatocellular carcinoma [0.03%]
AGTRAP通过p38 MAPK途径介导癌细胞和巨噬细胞之间的外泌体驱动通讯以促进肝细胞癌的发展
Shanshan Liu,Zhenghang Li,Hongqing Liu et al.
Shanshan Liu et al.
Background: Angiotensin II Receptor-Associated Protein (AGTRAP) is markedly overexpressed in hepatocellular carcinoma (HCC) cases associated with poor prognosis; however, its precise functional role remains inadequately e...
Collateral lethality of NAD kinase in 1p36 deleted tumors drives vulnerability to NAD kinase 2 depletion [0.03%]
1p36缺失肿瘤中NAD激酶的旁观者致死性导致其对NAD激酶2缺乏敏感
Saki Suyama-Banjo,Kengo Watanabe,Hirokazu Ishikawa et al.
Saki Suyama-Banjo et al.
The deletion of tumor suppressor genes often occurs in a tumor-specific manner and is accompanied by the unintended loss of adjacent genes. Nicotinamide adenine dinucleotide kinase (NADK), located at a tumor suppressive locus on chromosome ...
Structural modification of 5-alkyl-4-phenyl-thiazole-based fatty acid amide hydrolase and soluble epoxide hydrolase inhibitors to alleviate orofacial inflammatory pain in the rat [0.03%]
基于5-烷基-4-苯基噻唑的脂肪酸酰胺水解酶和可溶性环氧化物水解酶结构修饰以缓解大鼠颌面部炎症痛
Gabrielle Gorostiza,Madison Mercado,Lucy Pavana et al.
Gabrielle Gorostiza et al.
Orofacial pain is difficult to manage. Treatments like nonsteroidal anti-inflammatory drugs (NSAIDs), and serotonin agonists provide limited relief or produce side effects. These limitations highlight the need for alternative strategies tha...
Purinergic signaling modulates endothelial-to-mesenchymal transition in human aortic valve endothelial cells [0.03%]
嘌呤能信号调节人主动脉瓣内皮细胞向间充质细胞的转化
Vera Schmidt,Andreas Weber,Artur Lichtenberg et al.
Vera Schmidt et al.
Endothelial-to-mesenchymal transition (EndMT) is a phenotypic switch in which endothelial cells acquire mesenchymal characteristics, involving both functional and morphological changes. While EndMT is essential for cardiac development, its ...
Bioactive derivatives of the antimicrobial peptide esculentin-1a promote human dermal fibroblast migration and activate genes involved in early wound healing [0.03%]
抗菌肽_esculentin-1a的生物活性衍生物可促进人真皮成纤维细胞迁移及启动与早期伤口愈合相关的基因表达
Floriana Cappiello,Eleonora Grisard,Alice Traversa et al.
Floriana Cappiello et al.
Antimicrobial peptides (AMPs) are essential components of the innate immune system and have emerged as promising candidates against antibiotic-resistant infections. Beyond their antimicrobial activity, AMPs also play a crucial role in regul...
Inhibitors of phosphodiesterase 1 enhance paclitaxel cytotoxicity in a MDA-MB-231-derived cell line by promoting microtubule stabilization [0.03%]
磷二酯酶1抑制剂通过促进微管稳定化增强紫杉醇细胞毒性：对MDA-MB-231衍生的乳腺癌细胞系的作用机制研究
Hsiao-Hui Kuo,Chien-Wei Huang,Tsai-Ming Lu et al.
Hsiao-Hui Kuo et al.
Resistance of tumor cells to chemotherapy remains a critical obstacle to effective cancer treatment. Although paclitaxel is one of the most commonly used chemotherapeutic agents for treating triple-negative breast cancer (TNBC), the mechani...