Fluid shear stress activates c-Src and promotes RANKL localization in the plasma membrane in osteoblast-like MC3T3-E1 cells [0.03%]
流体剪切应力激活c-Src并促进成骨细胞样MC3T3-E1细胞中RANKL在质膜上的定位
Takuma Matsubara,Anna Yoshimura,Shoichiro Kokabu
Takuma Matsubara
Receptor activator of NF-κB ligand (RANKL) produced by osteoblastic lineage cells is essential for osteoclastogenesis, yet RANKL can be sequestered in intracellular, lysosome-like compartments under basal conditions. How mechanical cues mo...
Adjacent domains drive the emergence of misfolded intermediates in the folding pathway of the PDZ4 from MAGI1 [0.03%]
相邻结构域驱动MAGI1PDZ4在折叠途径中错误折叠中间体的出现
Valeria Pennacchietti,Cosmin Marian Obreja,Dimitrios Marinidis et al.
Valeria Pennacchietti et al.
Protein misfolding in multidomain assemblies emerges from a complex interplay between intra- and interdomain interactions. Here, we dissect how neighboring domains shape the folding and misfolding of the PDZ4 domain from the scaffold protei...
TCA cycle intermediates as an adjunct strategy for human iPSC-derived cardiomyocyte maturation [0.03%]
TCA循环中间产物作为人多能干细胞源心肌细胞成熟的辅助策略
Keshav Narayan Alagarsamy,Emilee Bueckert,Mehak Gupta et al.
Keshav Narayan Alagarsamy et al.
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are a valuable tool for modeling cardiac diseases, drug testing, and regenerative applications. However, their application is limited by the immature phenotype of iPSC-CM....
Thermodynamic signatures in ß-oxidation drive selective mobilization of fatty acids during negative energy balance in white adipose tissues [0.03%]
白色脂肪组织在负能量平衡期间选择性动员脂肪酸的β氧化热力学特征信号
Natarajan Ganesan
Natarajan Ganesan
A theoretical model of mitochondrial β-oxidation efficiency is presented, using ATP yield per oxygen atom (P:Oβ-ox) as a proxy for performance under oxygen-limited conditions. Expressed as a function of chain length and unsaturation, the ...
Deciphering a mechanistic basis for the pathological effect of the GNAO1 E246K variant in neurodevelopmental disorder [0.03%]
揭示GNAO1E246K变异通过影响神经发育相关疾病病理的分子机制
Isra Sadiya,Irina Nekrasova,Meirav Avital-Shacham et al.
Isra Sadiya et al.
Pathogenic variants in the GNAO1 gene, which encodes for Gαo, a major neuronal G protein, are associated with neurodevelopmental disorders, epilepsy, and movement disorders. We identified and characterized in detail a de novo heterozygous ...
Lipidomic profiling of Arabidopsis chloroplast protein phosphatase SLP1 mutants reveals altered diurnal lipid remodeling [0.03%]
拟南芥质体蛋白磷酸酶SLP1突变体的脂质组学分析揭示了昼夜节律脂质重塑的改变
Chris White-Gloria,Greg B Moorhead,Adriana Zardini Buzatto
Chris White-Gloria
Lipids are fundamental to the biology of all organisms, including the functioning of subcellular organelles. The plant chloroplast is the site of photosynthesis and serves as a hub of metabolic events that are dynamically regulated between ...
Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs [0.03%]
α-突触核蛋白的隐藏面：由疾病、突变和翻译后修饰驱动的原纤维多态性的冷冻电镜揭示
Mitra Pirhaghi,Fatemeh Mamashli,Bagher Davaeil et al.
Mitra Pirhaghi et al.
Alpha-synuclein (α-Syn) is a neuronal protein implicated in the pathogenesis of several neurodegenerative disorders collectively known as synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atro...
TGF-β2/OPTN/FOXC1/ miR-200 axis regulates actin dynamics in human trabecular meshwork cells [0.03%]
转化生长因子β2/OPTN/FOXC1/miR-200轴调控人小梁网细胞肌动蛋白动力学
Chenna Kesavulu Sugali,Navya Naidu Gajula,Suresh Chava et al.
Chenna Kesavulu Sugali et al.
Glaucoma is the second leading cause of irreversible blindness globally, with elevated intraocular pressure (IOP) being its primary risk factor. Current therapeutic approaches, such as beta-blockers, alpha-adrenergic agonists, Rho-kinase in...
Introduction to a special issue, "Expanded glycomics: A bridge over future glycomics" [0.03%]
专刊序言：“扩展糖组学——通向未来糖组学的桥梁”
Jun Hirabayashi,Yann Guerardel
Jun Hirabayashi
CEMIP promotes gefitinib resistance in lung cancer with EGFR-mutation possibly through forming a stable complex CEMIP/c-MYC [0.03%]
CEMIP通过形成稳定的CEMIP/c-MYC复合物可能促进EGFR突变肺癌细胞的吉非替尼耐药性
Li Li,Jiaxiu Xie,Jinxing Liang et al.
Li Li et al.
While gefitinib greatly improves the prognosis of lung cancer patients with epidermal growth factor receptor (EGFR) mutation, its inevitable resistance severely diminishes therapeutic efficacy. Cell migration-inducing protein (CEMIP) might ...