Thermodynamic signatures in ß-oxidation drive selective mobilization of fatty acids during negative energy balance in white adipose tissues [0.03%]
白色脂肪组织在负能量平衡期间选择性动员脂肪酸的β氧化热力学特征信号
Natarajan Ganesan
Natarajan Ganesan
A theoretical model of mitochondrial β-oxidation efficiency is presented, using ATP yield per oxygen atom (P:Oβ-ox) as a proxy for performance under oxygen-limited conditions. Expressed as a function of chain length and unsaturation, the ...
Deciphering a mechanistic basis for the pathological effect of the GNAO1 E246K variant in neurodevelopmental disorder [0.03%]
揭示GNAO1E246K变异通过影响神经发育相关疾病病理的分子机制
Isra Sadiya,Irina Nekrasova,Meirav Avital-Shacham et al.
Isra Sadiya et al.
Pathogenic variants in the GNAO1 gene, which encodes for Gαo, a major neuronal G protein, are associated with neurodevelopmental disorders, epilepsy, and movement disorders. We identified and characterized in detail a de novo heterozygous ...
Lipidomic profiling of Arabidopsis chloroplast protein phosphatase SLP1 mutants reveals altered diurnal lipid remodeling [0.03%]
拟南芥质体蛋白磷酸酶SLP1突变体的脂质组学分析揭示了昼夜节律脂质重塑的改变
Chris White-Gloria,Greg B Moorhead,Adriana Zardini Buzatto
Chris White-Gloria
Lipids are fundamental to the biology of all organisms, including the functioning of subcellular organelles. The plant chloroplast is the site of photosynthesis and serves as a hub of metabolic events that are dynamically regulated between ...
Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs [0.03%]
α-突触核蛋白的隐藏面：由疾病、突变和翻译后修饰驱动的原纤维多态性的冷冻电镜揭示
Mitra Pirhaghi,Fatemeh Mamashli,Bagher Davaeil et al.
Mitra Pirhaghi et al.
Alpha-synuclein (α-Syn) is a neuronal protein implicated in the pathogenesis of several neurodegenerative disorders collectively known as synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atro...
TGF-β2/OPTN/FOXC1/ miR-200 axis regulates actin dynamics in human trabecular meshwork cells [0.03%]
转化生长因子β2/OPTN/FOXC1/miR-200轴调控人小梁网细胞肌动蛋白动力学
Chenna Kesavulu Sugali,Navya Naidu Gajula,Suresh Chava et al.
Chenna Kesavulu Sugali et al.
Glaucoma is the second leading cause of irreversible blindness globally, with elevated intraocular pressure (IOP) being its primary risk factor. Current therapeutic approaches, such as beta-blockers, alpha-adrenergic agonists, Rho-kinase in...
Introduction to a special issue, "Expanded glycomics: A bridge over future glycomics" [0.03%]
专刊序言：“扩展糖组学——通向未来糖组学的桥梁”
Jun Hirabayashi,Yann Guerardel
Jun Hirabayashi
CEMIP promotes gefitinib resistance in lung cancer with EGFR-mutation possibly through forming a stable complex CEMIP/c-MYC [0.03%]
CEMIP通过形成稳定的CEMIP/c-MYC复合物可能促进EGFR突变肺癌细胞的吉非替尼耐药性
Li Li,Jiaxiu Xie,Jinxing Liang et al.
Li Li et al.
While gefitinib greatly improves the prognosis of lung cancer patients with epidermal growth factor receptor (EGFR) mutation, its inevitable resistance severely diminishes therapeutic efficacy. Cell migration-inducing protein (CEMIP) might ...
Identification of aberrant α-2,3 sialylation of cartilage associated with osteonecrosis of the femoral head based on integrated multi-omics analyses [0.03%]
基于整合多组学分析的股骨头坏死软骨异常α-2，3岩藻糖基化识别
Xueliang Lu,Xu Wang,Mingyue Xiong et al.
Xueliang Lu et al.
Purpose: Osteonecrosis of the femoral head (ONFH) is one of the most common and devastating articular cartilage diseases worldwide. The role of glycosylation in cartilage degeneration of ONFH is not yet fully understood. ...
Albumin does not induce IL-6 release and toll-like receptor activation in vitro: Role of endotoxin contamination and biochemical modifications [0.03%]
白蛋白不诱导IL-6释放和 Toll 样受体激活：内毒素污染作用及生化修饰的作用
Margret Paar,Vera H Fengler,Martina Schweiger et al.
Margret Paar et al.
Human serum albumin (HSA) is widely used in both clinical and research settings, yet its potential to stimulate immune responses remains poorly understood. In this study, we systematically investigated various therapeutic, recombinant and p...
Isonardosinone suppresses osteoclastogenesis through TRAF2/TRAF6-mediated disruption of calcium signaling and coordinate inhibition of MAPK/NF-κB pathways [0.03%]
异纳豆酚通过TRAF2/6介导的钙信号干扰及协同抑制MAPK/NF-κB通路抑制破骨细胞生成
Jielong Huang,Yang Lv,Chujie Wang et al.
Jielong Huang et al.
Background: Osteoporosis (OP), a prevalent age-related skeletal disorder, is characterized by increased osteoclast (OC) activity, leading to bone loss, reduced bone mineral density, and elevated fracture risk. Through com...