C11orf21, a novel RUNX1 target gene, is down-regulated by RUNX1-ETO [0.03%]
新的RUNX1靶基因C11orf21受到RUNX1-ETO的抑制
Akifumi Matsumoto,Tatsushi Yoshida,Takahiro Shima et al.
Akifumi Matsumoto et al.
The fusion protein RUNX1-ETO is an oncogenic transcription factor generated by t(8;21) chromosome translocation, which is found in FAB-M2-type acute myeloid leukemia (AML). RUNX1-ETO is known to dysregulate the normal RUNX1 transcriptional ...
A review of the "metallome" within neurons and glia, as revealed by elemental mapping of brain tissue [0.03%]
脑组织元素映射揭示的神经元和胶质细胞中的“金属组”综述
Gaewyn Ellison,Ashley L Hollings,Mark J Hackett
Gaewyn Ellison
It is now well established that transition metals, such as Iron (Fe), Copper (Cu), and Zinc (Zn) are necessary for healthy brain function. Although Fe, Cu, and Zn are essential to the brain, imbalances in the amount, distribution, or chemic...
mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection [0.03%]
脑神经退行性病变与神经保护作用下的mTOR/α-酮戊二酸介导的信号通路
Olha Kostiuchenko,Iryna Lushnikova,Magdalena Kowalczyk et al.
Olha Kostiuchenko et al.
Cerebral disorders are largely associated with impaired cellular metabolism, despite the regulatory mechanisms designed to ensure cell viability and adequate brain function. Mechanistic target of rapamycin (mTOR) signaling is one of the mos...
Subcellular localization of X-linked inhibitor of apoptosis protein (XIAP) in cancer: Does that matter? [0.03%]
X染色体连锁的凋亡抑制蛋白(XIAP)在癌症中的亚细胞定位：重要吗？
B S Mendonça,C A Ferreira,R C Maia et al.
B S Mendonça et al.
X-linked inhibitor of apoptosis protein (XIAP) finely tunes the balance between survival and death to control homeostasis. XIAP is found aberrantly expressed in cancer, which has been shown to promote resistance to therapy-induced apoptosis...
Regulation and functions of membrane lipids: Insights from Caenorhabditis elegans [0.03%]
膜脂的调节和功能：来自秀丽隐杆线虫的启示
Muhasin Koyiloth,Sathyanarayana N Gummadi
Muhasin Koyiloth
The Caenorhabditis elegans plasma membrane is composed of glycerophospholipids and sphingolipids with a small cholesterol. The C. elegans obtain the majority of the membrane lipids by modifying fatty acids present in the bacterial diet. The...
Interaction of a short antimicrobial peptide on charged lipid bilayer: A case study on aurein 1.2 peptide [0.03%]
抗菌肽与带电脂质膜的相互作用——以 aurein 1. 2 肽为例研究
Shuo Qian,Piotr A Zolnierczuk
Shuo Qian
Aurein 1.2 (aurein) is a short but active α-helical antimicrobial peptide discovered in Australian tree frogs (Litoria aurea). It shows inhibition on a broad spectrum of bacteria and cancer cells. With well-defined helicity, amphipathicity...
Cerosomes as skin repairing agent: Mode of action studies with a model stratum corneum layer at liquid/air and liquid/solid interfaces [0.03%]
细胞弹力肽作为皮肤修复剂的研究：以模型角质层在液气和液固界面的方式作用研究
Fabio Strati,Tetiana Mukhina,Reinhard H H Neubert et al.
Fabio Strati et al.
The stratum corneum (SC) is the largest physical barrier of the human body. It protects against physical, chemical and biological damages, and avoids evaporation of water from the deepest skin layers. For its correct functioning, the homeos...
A solution NMR view of lipidic cubic phases: Structure, dynamics, and beyond [0.03%]
溶液NMR研究类脂立方相结构、动力学及展望
Thomas G Meikle,David W Keizer,Frances Separovic et al.
Thomas G Meikle et al.
Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a range of time ...
Biochemically prepared C-reactive protein conformational states differentially affect C1q binding [0.03%]
生化制备的C反应蛋白构象状态对C1q结合的影响不同
Carrie L Moon,Aml A Alnaas,Yuheng Cai et al.
Carrie L Moon et al.
C-reactive protein (CRP) is commonly measured as an inflammatory marker in patient studies for coronary heart disease, autoimmune disease and recent acute infections. Due to a correlation of CRP to a vast number of disease states, CRP is a ...
Application of zinc oxide nanoflowers in environmental and biomedical science [0.03%]
ZnO纳米花在环境和生物医学科学中的应用
Victor Jeevan Raj,Rita Ghosh,Agnishwar Girigoswami et al.
Victor Jeevan Raj et al.
Zinc oxide (ZnO) nanostructures can be synthesized in nanoforms of spheres, rods, flowers, disks, walls, etc., among which nanoflowers have gained special attention due to their versatile biomedical and pollutant remedial applications in wa...