C11orf21, a novel RUNX1 target gene, is down-regulated by RUNX1-ETO
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The fusion protein RUNX1-ETO is an oncogenic transcription factor generated by t(8;21) chromosome translocation, which is found in FAB-M2-type acute myeloid leukemia (AML). RUNX1-ETO is known to dysregulate the normal RUNX1 transcriptional network, which shoul... ...
