A non-affinity-dependent high-resolution mass spectrometry method for detecting and typing monoclonal free light immunoglobulin chains [0.03%]
一种无需亲和性依赖的高分辨率质谱法检测及分型单克隆游离轻链免疫球蛋白
Per Bengtson,Magnus Förnvik Jonsson
Per Bengtson
Background: Detecting and monitoring monoclonal free light immunoglobulin chains in serum is important for managing patients with B-cell neoplasms. Established methods have relied on immunochemistry, with monoclonality de...
Adapting a commercial sample extraction protocol for biosafety level 3/4 compatible plasma metabolomics analysis [0.03%]
一种商业样品提取方案在生物安全三级/四级相容性血浆代谢组分析中的应用
J Brandsma,J W Thompson,K L Schully et al.
J Brandsma et al.
Introduction: Severe infections and sepsis significantly impact military operational readiness and costs through loss of duty days, high treatment rates, and medical evacuations. Early diagnosis is critical for preventing...
Interpretable machine learning of clinical MALDI-TOF spectra discriminates carbapenem-resistant Klebsiella pneumoniae while revealing phylogenetic heterogeneity that limits model generalizability [0.03%]
可解释的临床MALDI-TOF光谱机器学习区分碳青霉烯耐药肺炎克雷伯菌的同时揭示其限制模型泛化的谱型异质性
Chuangye Cai,Mengxue Zou,Mingxiao Chen et al.
Chuangye Cai et al.
Introduction: Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant public health threat. Rapid detection of CRKP and its resistance mechanisms is essential for optimizing antibiotic therapy and infection ...
Evaluation of thermal desorption-electrospray ionization mass spectrometry for characterization of Mycobacterium tuberculosis: Comparison with MIRU-VNTR and whole-genome sequencing [0.03%]
热解吸-电喷雾离子化质谱表征结核分枝杆菌：与MIRU-VNTR和全基因组测序比较
Tsung-Ying Yang,Hung Su,Shu-Huei Jain et al.
Tsung-Ying Yang et al.
Background: Typing Mycobacterium tuberculosis (MTB) isolates is important for identifying clusters and guiding infection control measures. Although whole-genome sequencing (WGS) and 24-loci mycobacterial interspersed repe...
Quantification of eight clinically relevant serum adrenal steroids in infants by UHPLC-APCI-MS/MS [0.03%]
采用UHPLC-APCI-MS/MS法对婴儿临床相关血清肾上腺皮质激素的定量分析
Manuela R Martinefski,Verónica Ambao,María Gabriela Ballerini et al.
Manuela R Martinefski et al.
Background and aims: There is growing interest in replacing steroid immunoassays with liquid chromatography-tandem mass spectrometry-based methods in many clinical and research applications. The aim of the present work is...
A Label-Free blocking immunoassay to evaluate Anti-Adalimumab antibody activity in clinical samples [0.03%]
一种基于临床上样本的评价抗阿达木单抗抗体活性的非标记阻断免疫测定法
Judi Abdelrazik,Naomi Iwai,Yonghua Liu et al.
Judi Abdelrazik et al.
Background: Adalimumab (ADL), a monoclonal antibody targeting TNF-⍺, is widely used to treat autoimmune diseases, but its efficacy can diminish over time due to the development of antidrug antibodies (ADAs), particularly...
Mahdiyeh Shahi,R Graham Cooks
Mahdiyeh Shahi
Cancer is the second leading cause of death in the United States, and with ongoing population growth and aging, its annual incidence continues to rise. Glioma is a malignant tumor of the brain and central nervous system (CNS). Neurosurgical...
Tear fluid proteomics: a comparative study of DIA and DDA mass spectrometry [0.03%]
泪液蛋白质组学：宽数据依赖(acqdia)与数据依赖采集(dda)质谱比较研究
Saleh Ahmed,Jeremy Altman,Garrett Jones et al.
Saleh Ahmed et al.
Background: Mass spectrometry is a powerful technique for tear fluid proteomics, offering critical insights into its complex molecular composition. Traditional data-dependent acquisition (DDA) often favors high-abundance ...
Maria M Derkach,Anatoly A Sorokin,Andrey A Kuzin et al.
Maria M Derkach et al.
Introduction: Image segmentation is an important challenge in mass spectrometry imaging data processing. Here, we report an unsupervised topological segmentation method adapted to the specific nature of mass spectrometry ...
Measurement of twenty-one serum steroid profiles by UPLC-MS/MS for the diagnosis and monitoring of congenital adrenal hyperplasia [0.03%]
用于先天性肾上腺增生诊断和监测的21种血清甾体谱型的UPLC-MS/MS测定方法
Joon Hee Lee,Kyunghoon Lee,Sun-Hee Jun et al.
Joon Hee Lee et al.
Background: Congenital adrenal hyperplasia (CAH) represents a group of inherited disorders affecting steroidogenesis. Early and accurate diagnosis is crucial for effective treatment, particularly for preventing adrenal in...